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Preparation method and application of soothing and repairing composition

A composition and soothing technology, which can be applied in the direction of skin care preparations, pharmaceutical formulas, cosmetic preparations, etc., can solve the problems of large initial investment in production equipment, failure to achieve green environmental protection, and no green environmental protection, etc., to achieve higher economic benefits Good, high yield of active ingredients, high yield of active ingredients

Active Publication Date: 2022-07-22
山东福瑞达生物股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the one hand, it fails to meet the requirements of green environmental protection, and the initial investment in production equipment is relatively large, so it is difficult to promote in the above-mentioned areas
At present, there is no deep processing technology for capillary, quinoa and other crops that are environmentally friendly and suitable for promotion in poor areas

Method used

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  • Preparation method and application of soothing and repairing composition
  • Preparation method and application of soothing and repairing composition
  • Preparation method and application of soothing and repairing composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] S1, rough extraction. After drying and pulverizing Yin Chen, sieve twice with a 40-mesh sieve and a 100-mesh sieve, weigh 10.0 kg of fine powder with a particle size between 40 and 100 mesh, and use 60.0 kg of water as the extraction solvent to carry out atomization extraction. . The extraction temperature is 15-35°C, and the extraction time is 30-35 minutes, after which the residues of sagebrush are filtered off to obtain a crude extract of sagebrush;

[0046] S2, deacidification. Filtration of the crude extract of Rhizoma chinensis, then adding 0.6kg of 80 mesh neutral alumina thereto, stirring for more than 60min, filtering out the solid matter to obtain the extracting solution of Rhizoma chinensis;

[0047] S3, adsorption. The separation column is pre-filled with 15.0kg of D101 macroporous adsorption resin with a particle size of 0.3-1.2mm, and the filling height is not less than 1000mm. The Yinchen extract is injected from the top of the separation column, and f...

Embodiment 2

[0052] S1, rough extraction. After drying and pulverizing Yin Chen, sieve twice with a 40-mesh sieve and a 100-mesh sieve, weigh 10.0 kg of fine powder with a particle size between 40 and 100 mesh, and use 80.0 kg of water as the extraction solution to carry out atomization extraction. . The extraction temperature is 15~35℃, and the extraction time is 30~35min, and then the medicinal residue is filtered off to obtain a crude extract of Yinchen;

[0053] S2, deacidification. Filtration of the crude extract of Rhizoma chinensis, then adding 0.5kg of 80 mesh neutral alumina to it, stirring for more than 60min, filtering out the solid matter to obtain the extracting liquid of Rhizoma chinensis;

[0054] S3, adsorption. Two-stage series separation columns are used, the resin filling height of each stage is not less than 500mm, AB-8 macroporous adsorption resin with a particle size of 0.3-1.2mm is used, and the total resin filling weight of the two-stage separation column is 15kg...

experiment example 1

[0076] Experimental Example 1 Soothing efficacy test

[0077] The soothing efficacy of the samples was evaluated by detecting the inhibitory effect of the samples on the expression of HaCaT-TRPV1 cytokines induced by capsaicin (CAP).

[0078] TRPV1 (transient receptor potential vanilloid receptor-1) is the target of primary sensory nerves that produce pain in response to physical and chemical stimuli. It is a Ca 2+ Channel proteins that can be activated by endogenous and exogenous vanillin-like substances, thermal stimulation, and tissue acidification, causing Ca 2+ Internal flow, which conducts pain signals in the peripheral nervous system. Keratinocytes (HaCaT) are activated by TRPV1 upon capsaicin (CAP) stimulation, causing Ca 2+ Influx and increased expression of inflammatory factors eventually lead to skin pain and itching. If the test substance has an inhibitory effect on the expression of cytokines induced by CAP, it indicates that it has a soothing effect.

[0079]...

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Abstract

The invention discloses a preparation method and application of a soothing and repairing composition. The preparation method comprises the following steps: extracting components such as phenylpropanoid substances in oriental wormwood by taking water as an extraction solvent, removing poor-stability organic acid and part of flavonoid substances in a crude extract of the oriental wormwood by using aluminum oxide, then adsorbing phenylpropanoid in the extract by using macroporous adsorption resin, and finally desorbing by using an eluent containing quinoa saponin components, thereby obtaining the soothing and repairing composition. The soothing and repairing composition can be directly applied to the skin surface after being diluted, and the effects of soothing and repairing the skin are achieved.

Description

technical field [0001] The invention belongs to the technical field of plant extraction, and relates to a preparation method and application of a soothing and repairing combination; in particular, it relates to a preparation process of the composition and its application in preparing a product with soothing and repairing effects. Background technique [0002] Allergic disease (also known as allergic disease) is not just a common disease, but has become a global epidemic. The etiology of allergic diseases has not yet been definitively concluded, such as the gradual deterioration of the living environment, ultraviolet radiation, lack of sleep, abuse of powerful drugs, etc., manifested as: itching, redness, tingling, flushing, red blood and other allergic symptoms. [0003] The currently known soothing compositions are only aimed at the above single symptom, relieve the sensitive reaction, and do not have the effect of comprehensively repairing damaged skin. Long-term use can ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61K8/63A61Q19/00B01D11/02
CPCA61K8/9789A61K8/63A61Q19/005B01D11/0288B01D11/0284A61K2800/805
Inventor 韩婷婷胡志娟杨素珍
Owner 山东福瑞达生物股份有限公司
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