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Injection gel composite microsphere and preparation method thereof

A technology of composite microspheres and gels, applied in the field of medical materials, can solve problems such as high risk, bubbles, redness, etc., achieve high biological safety, and reduce side effects.

Pending Publication Date: 2022-07-29
成都迪康中科生物医学材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, adding surfactants to sodium hyaluronate gel will not only increase the risk of side effects of sodium hyaluronate gel, but also surfactants are more likely to cause air bubbles, and the risk is also high
[0005] In addition, the existing sodium hyaluronate gel degrades faster in the body, and the shaping cycle is shorter. After the degradation, repeated injections are required to maintain the shaping effect
Although there are some fillers currently on the market, which are composed of cross-linked sodium hyaluronate and L-lactic acid-ethylene glycol copolymer microspheres, but the fillers use cross-linked hyaluronic acid gels, which have different degrees of cross-linking. Uniformity, irregular particle shape and uneven particle size, etc., when used for facial filling, it is easy to cause side effects such as redness and swelling due to irregular surface

Method used

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  • Injection gel composite microsphere and preparation method thereof
  • Injection gel composite microsphere and preparation method thereof
  • Injection gel composite microsphere and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] S1: L-polylactic acid microspheres were added to sodium chloride solution under the conditions of osmotic pressure 250mOsm / L and pH 7.0 for dispersion, followed by adding anesthetic lidocaine hydrochloride, sodium hyaluronate, silk fibroin and Organosilicon defoamer, after mixing uniformly, a mixture is obtained;

[0038] S2: put the mixture into a cellulose dialysis belt and use PBS buffer for dialysis, wherein the molecular weight of dialysis is 500, and dialysis is performed twice, after 10h dialysis each time; ℃, the pressure of 42kPa moist heat high pressure steam sterilization for 10 minutes, to obtain injection gel composite microspheres.

[0039] The mass fraction of the L-polylactic acid microspheres is 1%, the molecular weight is 50000, and the particle size is 20 μm, which is obtained by self-preparation; The preparation methods are similar, except that the molecular weight of L-polylactic acid is different: the molecular weight of L-polylactic acid used in E...

Embodiment 2

[0045] S1: L-polylactic acid microspheres were added to sodium chloride solution under the conditions of an osmotic pressure of 350 mOsm / L and pH 7.0 for dispersion, followed by the addition of anesthetic lidocaine hydrochloride, sodium hyaluronate, silk fibroin and Polyether defoamer for fermentation, after mixing uniformly, a mixture is obtained;

[0046] S2: Put the mixture into a cellulose dialysis belt and use PBS buffer for dialysis, wherein the molecular weight of dialysis is 1000, and dialysis is performed for 4 times, 13 hours each time, after the dialysis is completed; then the material is filled into a pre-filled syringe, and the temperature is 121 DEG C, pressure 103kPa moist heat high pressure steam sterilization for 30 minutes to obtain injection gel composite microspheres.

[0047] The mass fraction of the L-polylactic acid microspheres is 4%, the molecular weight is 80000, and the particle size of the microspheres is 30 μm, which is obtained by self-preparatio...

Embodiment 3

[0053] S1: L-polylactic acid microspheres were added to phosphate buffer under the conditions of an osmotic pressure of 300 mOsm / L and pH 7.0 for dispersion, followed by the addition of anesthetic lidocaine hydrochloride, sodium hyaluronate, silk fibroin and Polyether defoamer for fermentation, after mixing uniformly, a mixture is obtained;

[0054] S2: put the mixture into a cellulose dialysis belt and use PBS buffer for dialysis, wherein the molecular weight of dialysis is 1000, dialysis 3 times, each 12h, after the dialysis is completed; then fill the material into a pre-filled syringe, and the temperature is 120 DEG C, pressure 97kPa moist heat high pressure steam sterilization for 30 minutes to obtain injection gel composite microspheres.

[0055] The mass fraction of the L-polylactic acid microspheres is 2%, the molecular weight is 100,000, and the particle size of the microspheres is 50 μm, which is obtained by self-preparation; the preparation method of the L-polylact...

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Abstract

The invention belongs to the technical field of medical materials, and particularly relates to an injection gel composite microsphere and a preparation method thereof. The injection gel composite microsphere comprises a component A, a component B, silk fibroin, an anesthetic and a salt solution, the component A is prepared from sodium hyaluronate, collagen, recombinant collagen, chitosan or bacterial cellulose; and the component B is a polycaprolactone or polylactic acid derivative degradable material. The injection gel composite microsphere provided by the invention has a long-acting shaping effect; meanwhile, when the gel is sterilized by adopting a damp and hot high-pressure steam sterilization method, the microspheres are not easy to soften at high temperature, and the form can be well maintained; and no bubble is generated after packaging, no additive is required to be additionally introduced, and the biological safety is high.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and particularly relates to an injection gel composite microsphere and a preparation method thereof. Background technique [0002] Hyaluronic acid is a natural linear polysaccharide, a linear polysaccharide composed of N-acetylglucosamine and gluconic acid disaccharide units, with large molecular weight and certain viscoelastic properties. Due to the existence of hydrogen bonds in the linear axis of sodium hyaluronate, the sodium hyaluronate molecule presents a helical columnar structure in space, and the inner side of the helical column has strong hydrophilicity due to the existence of a large number of hydroxyl groups, and the hyaluronic acid molecule will The bound water molecules are locked in its double helix column structure, so that the water molecules are not easily lost, so it has a special water retention effect and is known as an ideal natural moisturizing factor. With the d...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61L27/20A61L27/22A61L27/24A61L27/50A61L27/52A61L27/58
CPCA61L27/24A61L27/227A61L27/20A61L27/18A61L27/58A61L27/52A61L27/50A61L2400/06A61L2430/34C08L89/00C08L5/08C08L67/04C08L1/02
Inventor 吴昊彭飞李晓萍陈宏杰张凯
Owner 成都迪康中科生物医学材料有限公司
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