Dual-modulus multifunctional self-adaptive coating, application thereof and medical intervention catheter

A multifunctional and self-adaptive technology, applied in catheters, coatings, etc., can solve the problems of not resistant to wear and shear, large overall thickness, poor colloid strength, etc., and achieve high flexibility, high degree of freedom, and strong hydration ability Effect

Active Publication Date: 2022-08-05
WEIGAO HLDG +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] However, so far there is hardly any surface modification method technology that can meet the above requirements in terms of modulus and function at the same time, and apply it to the construction of surface coatings for medical catheters
The existing physical adsorption coating method is simple and convenient, and the substrate has wide adaptability, but the coating and the substrate are mainly weakly interacted, the strength is poor, and it is easy to fall off; the polymer brush modification method has many types of monomers to choose from, It has a wide range of applications and can build low modulus systems. However, the thickness of the graft is at the nanometer level, and its performance is limited. Difficult to match (Adv.Mater.2018, 1807101; Adv.Healthcare Mater.2020, 2001116)

Method used

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  • Dual-modulus multifunctional self-adaptive coating, application thereof and medical intervention catheter
  • Dual-modulus multifunctional self-adaptive coating, application thereof and medical intervention catheter
  • Dual-modulus multifunctional self-adaptive coating, application thereof and medical intervention catheter

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preparation example Construction

[0097] The invention provides a preparation method of a dual-modulus multifunctional self-adaptive medical interventional catheter, comprising:

[0098] A) react the photo-initiated cationic substance solution with the anionic substance solution to obtain an anion-cation complex;

[0099] B) dissolving the anion-cation complex in an organic solvent to obtain a primer coating solution with a cross-linked structure;

[0100] C) loading the bottom layer solution on the medical interventional catheter, and carrying out ultraviolet curing treatment to obtain a primer-coated medical catheter with a cross-linked network structure;

[0101] D) Loading the outer layer solution of the linear polymer brush structure on the surface of the medical catheter with the cross-linked network structure primer coating, and UV curing treatment to obtain a dual-modulus multifunctional self-adaptive medical interventional catheter with a double-layer structure .

[0102] The invention provides a pr...

Embodiment 1

[0129] A) Prepare an aqueous solution of 4-(4-(diethylamino)benzoyl)-N with a concentration of 1 g / mL, and prepare an aqueous solution of sodium hyaluronate with a concentration of 0.5 g / mL; The aqueous solution of (diethylamino)benzoyl)-N was added dropwise to 8 ml of sodium hyaluronate solution until a large amount of white precipitate was precipitated in the solution. After standing for 1 h, the white precipitate was obtained by filtration. The precipitate was washed three times with ultrapure water and freeze-dried to obtain an anion-cation complex.

[0130] B) Dissolving the anion-cation complex obtained in the step A) in an acetone solution to prepare an anion-cation complex solution with a concentration of 3 g / mL; soak the polyurethane central venous catheter (weight A0) in the above-mentioned complex solution For 1 h, the acetone solvent was placed at 25°C to completely volatilize the acetone solvent to obtain a central venous catheter (weight A1) coated with a physica...

Embodiment 2

[0134] A) Prepare an aqueous solution of N-diethyl-N-octylphenylammonium iodide with a concentration of 0.5 g / mL, and prepare an aqueous solution of heparin sodium with a concentration of 1 g / mL; The aqueous solution of phenylammonium iodide was added dropwise to 5 ml of sodium heparin solution until a large amount of white precipitate was precipitated in the solution. After standing for 1.5 h, the white precipitate was obtained by filtration. The precipitate was washed three times with ultrapure water and freeze-dried to obtain an anion-cation complex.

[0135] B) Dissolving the anion and cation complex obtained in the step A) in an ethanol solution to prepare an anion and cation complex solution with a concentration of 1 g / mL; soak the polyurethane central venous catheter (weight A0) in the above complex solution For 45 minutes, the ethanol solvent was placed at 25° C. to completely volatilize to obtain a central venous catheter (weight A1) coated with a physical adsorption ...

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Abstract

The invention provides a dual-modulus multifunctional self-adaptive coating. The dual-modulus multifunctional self-adaptive coating comprises a bottom layer with a cross-linked structure and an outer layer with a linear polymer brush structure, the bottom layer of the cross-linked structure is prepared from the following raw materials: a photo-initiation type anion-cation compound and a solvent; the photo-initiation type anion-cation compound comprises a photo-initiation type cation substance and an anion substance; the outer layer raw material of the linear polymer brush structure comprises an outer layer monomer of a pH stimulation response type linear structure or a bacterial enzyme stimulation response type outer layer monomer. The coating provided by the invention comprises a bottom layer with a cross-linked structure and an outer layer with a stimuli-responsive polymer brush. A cross-linked network structure is arranged in the bottom layer, and the modulus is moderate; the outer layer is of a linear polymer brush structure and is large in flexibility, high in freedom degree and low in modulus. And the bottom layer composition substance contains a photosensitive structure unit which can directly initiate the grafting of the outer-layer polymer brush without adding a photoinitiator, so that the problems of migration, precipitation and the like of a small-molecule photoinitiator are avoided.

Description

technical field [0001] The invention relates to the technical field of biological materials, in particular to a dual-modulus multifunctional self-adaptive coating, its application and a medical interventional catheter. Background technique [0002] With the development of catheter diagnosis and treatment technology, the demand for medical catheters in the clinic continues to increase. Nearly 10 million cases are used every year, and the global output value exceeds 5 billion US dollars. However, during the clinical use of medical catheters, the incidence of related complications is 4-6%, which not only increases the economic burden of patients, but even leads to death. Common medical catheter-related complications, including physical blood vessel / tissue injury, catheter-related infection, catheter-related thrombosis, etc. Physical vascular / tissue damage is mainly caused by the direct stripping of endothelial cells during venipuncture and catheter placement, while the intrava...

Claims

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Application Information

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IPC IPC(8): A61L29/08A61L29/14A61L29/16A61M25/00
CPCA61L29/08A61L29/085A61L29/14A61L29/16A61M25/0043A61M25/0045A61L2300/404A61L2300/606A61L2420/02A61L2420/08A61L2420/06A61M2025/0046A61M2025/0047A61M2025/0056C08L5/10C08L5/08Y02A50/30
Inventor 周容涛石恒冲孙振龙孙传盛王楠张帅闫顺杰栾世方殷敬华
Owner WEIGAO HLDG
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