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Xanthine oxidase inhibitor

A technology of xanthine oxidase and inhibitor, applied in the field of medicine, can solve problems such as difference in inhibition rate, and achieve the effect of low toxicity

Pending Publication Date: 2022-08-09
云南伦扬科技有限公司
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

Quercetin, resveratrol, epigallocatechin gallate, hesperidin, carnosic acid, kaempferol, galangin and other polyphenolic monomers from natural sources have been reported to inhibit xanthine oxidase. It has been reported, but compared with the positive control drugs allopurinol and febuxostat, there is still a big difference in the inhibition rate

Method used

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Embodiment 1

[0017] 1. Preparation of tannic acid carbon dots: under nitrogen protection, 20 g of tannic acid, 5 g of copper sulfate and 10 g of glycine were dispersed in 1500 mL of deionized water, and then transferred to polytetrafluoroethylene for reaction The kettle was heated at 180 °C for 8 h, after natural cooling, centrifuged at 10,000 r / min for 10 min, the supernatant was passed through a 0.22 μm filter membrane, and vacuum dried to obtain tannic acid carbon dots.

[0018] 2. Mix the tannic acid carbon dots prepared in step 1 with tannic acid at a weight ratio of 20:80 to obtain a xanthine oxidase inhibitor (TA+TA / CDs).

[0019] 3. Cytotoxicity test of TA+TA / CDs inhibitor: MTT method was used to test the cytotoxicity of the inhibitor under the condition of pH 7.5; the experiment tested the proliferation rate of inhibitor L929 cells (fibroblasts), L929 cells were cultured on the inhibitor surface After 24, 48 and 72 hours, if figure 1 As shown, the proliferation rates of L929 cell...

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Abstract

The invention relates to the technical field of medicines, in particular to a xanthine oxidase inhibitor. A tannic acid carbon dot and tannic acid mixture which has good water solubility, low toxicity and biocompatibility and has a xanthine oxidase inhibition effect is used as a xanthine oxidase inhibitor, and the tannic acid carbon dot and the tannic acid are combined with hydrophobic residues of xanthine oxidase to form hydrogen bonds or generate a hydrophobic effect; and when being inserted into hydrophobic gaps of the xanthine oxidase, the xanthine oxidase occupies a catalytic activity center, and competes with a substrate xanthine to be combined with an active site of the xanthine oxidase, so that the substrate is prevented from entering, and the activity of the xanthine oxidase is reduced. In-vitro and in-vivo animal experiment results show that the xanthine oxidase inhibitor disclosed by the invention can be equivalent to hyperuricemia drugs in the prior art, is low in toxicity, and can be applied to health-care foods or drugs for preventing and treating hyperuricemia.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a xanthine oxidase inhibitor. Background technique [0002] Xanthine oxidase (XOD) is widely present in milk, human and animal cells, and is a key enzyme that catalyzes the metabolism of hypoxanthine and xanthine to uric acid in the human body. Uric acid is the final metabolite of purine compounds in the human body. Excessive XOD content and activity in the body will produce a large amount of uric acid, which will lead to hyperuricemia, gout and impaired motor function. Long-term hyperuricemia can also induce hypertension, diabetes, Coronary heart disease, kidney failure and other diseases. How to effectively reduce the formation of uric acid in the body is a hot research topic at home and abroad. XOD contains 1330 amino acids, 2 flavin adenine dinucleotides, 2 molybdenum atoms and 8 iron atoms, and is a key enzyme in the catalytic conversion of purine compounds. Xanthine oxi...

Claims

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Application Information

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IPC IPC(8): A61K33/44A61P19/06C01B32/15B82Y5/00B82Y30/00B82Y40/00A23L33/105A23L33/10A61K31/7024
CPCA61K33/44A61K31/7024A61P19/06C01B32/15B82Y5/00B82Y30/00B82Y40/00A23L33/105A23L33/10A23V2002/00A61K2300/00A23V2200/30A23V2250/2132
Inventor 李秋兰王艺洁尹孟佳张倩杨亚玲
Owner 云南伦扬科技有限公司
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