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Hydrogel loaded with monatomic platinum and antitumor drug as well as preparation method and application of hydrogel

An anti-tumor drug and hydrogel technology, applied in the field of biomedicine, can solve the problems of limited treatment methods and treatment effects, and achieve the effects of reducing tumor recurrence rate, improving mechanical strength, excellent photothermal performance and photostability

Pending Publication Date: 2022-08-09
CANCER CENT OF GUANGZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the current treatment methods and therapeutic effects of photothermal therapy related technologies are still limited, and some new surgical adjuvant treatment strategies are urgently needed to provide new treatment ideas for tumor treatment

Method used

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  • Hydrogel loaded with monatomic platinum and antitumor drug as well as preparation method and application of hydrogel
  • Hydrogel loaded with monatomic platinum and antitumor drug as well as preparation method and application of hydrogel
  • Hydrogel loaded with monatomic platinum and antitumor drug as well as preparation method and application of hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A hydrogel loaded with monoatomic platinum and antitumor drugs, the specific preparation method is as follows.

[0039] (1) Preparation of methacrylated silk fibroin (SFMA)

[0040] Submerge 10g of silk cocoons in 1L of 0.05M Na 2 CO 3 The solution was boiled at 100° C. for 30 minutes, washed several times with distilled water to obtain degummed silk fibroin (SF), and the degummed silk fibroin was dried in a drying oven for 36 hours. Take 10g of degummed silk fibroin and dissolve it in 9.3M lithium bromide (LiBr) solution at 60°C for 1 hour, turn on the magnetic stirrer to stir, and slowly add 6mL of glycidyl methacrylate (GMA) dropwise. Filter through Miracloth and remove salt, use a dialysis bag (molecular weight cut-off 12000Da) to dialyze against distilled water for 7 days, and freeze the resulting methacrylated silk fibroin solution at -80°C for 12 hours, then freeze-dried After 36 hours, spongy SFMA was obtained.

[0041] (2) Preparation of methacrylated gelat...

experiment example 1

[0074] The single-atom platinum nanoparticles prepared in Example 1 were taken, diluted with deionized water, adjusted to an appropriate concentration, uniformly dispersed by ultrasonic, and then tested by TEM. During the test, a drop of the dispersed droplet was taken on the copper grid of transmission electron microscope, vacuum dried at 40 °C, and then observed and photographed under the transmission electron microscope. The results are as follows figure 1 shown.

[0075] from figure 1 It can be seen that the prepared single-atom platinum has a wrinkled and sheet-like structure, and the sheet-like structure has high transparency, indicating that the single-atom platinum has ultrathin characteristics.

experiment example 2

[0077] Take 3-5 mg of SF, SFMA, Gel (gelatin) and GelMA involved in Example 1 respectively, use deuterated heavy water as a solvent, and after the solution is completely dissolved, put it into a clean nuclear magnetic tube, and use a nuclear magnetic resonance spectrometer at room temperature. The NMR structure was determined under the following conditions, and the map was analyzed by MestReNova software. H NMR spectrum as figure 2 shown.

[0078] from figure 2 A NMR comparative analysis shows that, relative to SF, the hydrogen spectrum of SFMA has new absorption peaks at chemical shifts 5.6 and 6.1, corresponding to the absorption peaks of hydrogen on methacryloyl groups, indicating that methacryloyl groups were successfully grafted on SF. above, which confirmed the successful preparation of SFMA.

[0079] from figure 2 B NMR comparative analysis shows that, relative to Gel, the hydrogen spectrum of GelMA has new absorption peaks at chemical shifts 5.7 and 6.2, corresp...

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Abstract

The invention provides hydrogel loaded with monatomic platinum and an anti-tumor drug as well as a preparation method and application of the hydrogel, and relates to the technical field of biological medicines. The hydrogel is prepared by the following method: dissolving methacrylic acid gelatin in water, adding methacrylated silk fibroin, monatomic platinum, a water-soluble anti-tumor drug and a photoinitiator, uniformly mixing, and illuminating to obtain the hydrogel loaded with monatomic platinum and the anti-tumor drug. The hydrogel disclosed by the invention simultaneously loads monatomic platinum and an anti-tumor drug, has relatively good mechanical property, excellent photo-thermal performance and light stability, can sustainably release the drug, and has antibacterial and anti-tumor effects.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a hydrogel loaded with monoatomic platinum and an antitumor drug, and a preparation method and application thereof. Background technique [0002] At present, surgery is an indispensable treatment in the treatment of solid tumors. Tumor recurrence and wound infection are two major challenges after surgery. In order to obtain the maximum therapeutic benefit, adjuvant combined therapy before or after surgery is required. Therefore, neoadjuvant combined therapy and postoperative adjuvant combined therapy play an increasingly important role in improving the clinical treatment effect of patients. [0003] Hyperthermia (HTT) is a treatment method that uses different excitation sources (such as radio frequency, microwave, ultrasound, laser, etc.) to increase the local temperature of cancer tissue to achieve tumor ablation. The main tumor treatment method, HTT has obvious beneficial...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K31/7068A61K9/06A61K47/42A61P35/00
CPCA61K41/0052A61K31/7068A61K9/06A61K47/42A61P35/00A61K2300/00
Inventor 郑燕芳
Owner CANCER CENT OF GUANGZHOU MEDICAL UNIV
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