Composition containing extracts of pagodatree fruits, grape seeds and peel and preparation method thereof

An extract and grape seed technology, applied in the field of compositions containing Sophora japonica, grape seed, and skin extracts, can solve the problems of weakened mineralization, expensive calcitonin, and narrow therapeutic window, and achieve environmental protection, Good results from treatment

Inactive Publication Date: 2007-05-30
刘晓华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Long-term use of estrogen has been reported to cause cancer; calcium preparations only increase blood calcium, not bone formation, and the widespread use of calcium preparations has not reduced the fracture rate; calcitonin is expensive; bisphosphonates have obvious Gastrointestinal adverse reactions, etc.; in order to achieve an effective therapeutic effect, a large dose (75mg) of fluoride must be taken daily, and the therapeutic window is narrow. High dose administration will also cause toxicity to bone cells, weaken mineralization, and reduce bone subsidence rate cause side effects such as osteomalacia

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Sophora japonica extract with genistein 1.5 kg

[0050] Grape seed and skin extract containing proanthocyanidins 1.5 kg

[0051] The extraction method of the Sophora japonica extract containing genistein is as follows:

[0052] Sophora japonica is dried, crushed, steamed in a steamer for 30 minutes, added nutrients that are conducive to the growth of Aspergillus oryzae, such as 20% bran, inoculated with Aspergillus oryzae, fermented in a clean environment at 30°C, and then squeezed and filtered. The filter residue is extracted with 70% ethanol at 60°C, filtered, concentrated to recover ethanol, the extract is settled in water, filtered, recrystallized from ethanol, and spray-dried to obtain the Sophora japonica extract containing genistein up to 90%. Contains 6% rutin, 4% kaempferol.

[0053] The extraction method of the grape seed and skin extract containing proanthocyanidins is as follows:

[0054] Grape seeds and skins are cold-pressed to remove oil, extracted wit...

Embodiment 2

[0057] Sophora japonica extract with genistein 1 kg

[0058] Grape seed and skin extract containing proanthocyanidins 1 kg

[0059] Its extraction method is identical with the method of embodiment 1.

Embodiment 3

[0061] Sophora japonica extract with genistein 3 kg

[0062] Grape seed and skin extract containing proanthocyanidins 3kg

[0063] Its extraction method is identical with the method of embodiment 1.

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PUM

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Abstract

The invention relates to a composition containing extracts of pagodatree fruits, grape seeds and peel and preparation method, wherein the preparation method employs a biochemically method, the preparation has the functions of increasing compact bone substance density, oxidation resistance, alleviation of climacteric symptom, and prevention and cure of cardiovascular diseases.

Description

1. Technical field: [0001] The invention relates to a composition containing extracts of locust fruit, grape seed and skin and a preparation method thereof. Specifically, a biochemical method is used to prepare a medicine with health effects such as increasing bone density, anti-oxidation, relieving menopausal symptoms, and preventing and treating cardiovascular diseases, using locust fruit, grape seeds, and skin as raw materials. 2. Background technology: [0002] People who suffer from aging and various degenerative diseases due to the reduction of the body's antioxidant capacity, people who need to prevent and treat osteoporosis, people who need to prevent and treat cardiovascular diseases, women with menopausal symptoms, etc., all need drugs to relieve the disease. Existing products include soybean isoflavones. The soybean isoflavones mainly contain a mixture of various flavonoids such as genistin and daidzin. They mainly exist in the form of glycosides and need to be de...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/87A61K9/00A61P39/06A61P15/12A61P9/00A61P19/08A61K131/00
Inventor 刘晓华
Owner 刘晓华
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