Method for preparing artificial bone

Abstract

The present invention, preparation process of artificial bone, belongs to biomedicine material technology. The artificial bone can promote vascularization, improve blood circulation, simulate the synergistic action of various osteoplastic factors in body for forming bone well. Technologically, the preparation process of artificial bone includes the steps of preparing cradle, compounding bone forming active factor, sterilizing, assembling and characterized compounding vascular endothelial growth factor. The compounding of bone morphogenitic protein factor, transforming growth factor and vascular endothelial growth factor solves the problem of vascularization and blood supply during the process of forming bone. The vascular endothelial growth factor can promote proliferation and differentiation of vascular endothelial cell and vascularization and raise the capacity of forming bone and vascularization greatly.

Description

technical field [0001] The invention relates to a method for making a medical bionic bone, belonging to the technical field of biomedical materials. Background technique [0002] Bone defect and nonunion have always been difficult problems for orthopedics, stomatology, brain surgery and other disciplines. Experts at home and abroad have been committed to finding ideal bone graft materials. For a long time, autologous bone grafting has been a standard method, but the amount of bone obtained by this method is limited, especially for children. However, the bone quality of the ossuary is very unstable, the rate of re-fracture is high, and there is the possibility of disease transmission. In recent years, experts from various countries have successively developed a variety of alternative materials and preparation processes to replace autologous bone. For example, Chinese patent 94244566. Its preparation method", 99119851.4 discloses "a new type of bone repair material", and 011...

AI Technical Summary

Problems solved by technology

At present, this technology has made some progress, but in the above-mentioned composite bone growth factor technology, the blood vessel formation and blood supply after the artificial bone graft material is implanted into the human body are not involved, which is a big shortcoming

First of all, studies have shown that the growth of callus at the site of fracture healing or bone graft material filling is directly proportional to the amount of local blood vessel formation and blood supply. If there is little or no blood vessel formation and blood supply, the amount of bone formation is small or even impossible. Osteogenesis; secondly, fracture repair is a complex pathological process involving the proliferation and differentiation of various cells and the synthesis and mineralization of extracellular matrix. With the development of molecular biology techniques, it has been found that there are A variety of growth factors, they cooperate with each other, influence each other, and promote each other in the process of fracture healing. Only adding BMP factors is not enough, and it cannot complete osteogenesis in the true sense