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Nocar ointment for treating herpes simplex and herpes zoster

A technology for herpes zoster and herpes simplex, which is applied in the directions of ointment delivery, bacterial medical raw materials, emulsion delivery, etc., can solve the intractable pain of herpes, which can not achieve the slightest therapeutic effect, and recurs from time to time, which is unfavorable. It can improve the anti-tumor effect of the body, prevent recurrence, and reduce the economic burden.

Inactive Publication Date: 2004-01-07
LIAONING GREATEST BIO-PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Topical treatment of skin diseases plays an important role in the therapeutics of skin diseases, but there is no satisfactory topical drug for these two kinds of skin diseases. Some local anti-infection and damaged surface drugs are used for skin damage. These drugs usually only relieve symptoms but have no therapeutic effect on the intractable pain caused by herpes, so they often lead to Some patients left intractable neuralgia for several months after the skin lesions subsided; other antiviral drugs have certain antiviral effects, but these drugs only play a role in inhibiting the virus, and do not affect the body's immune system. The immune system has no regulatory effect, that is to say, it treats the symptoms but not the root cause, so relapses occur from time to time after the cure
In addition, sometimes there are local irritation symptoms such as pain, burning sensation, itching, redness and local allergic reaction symptoms in the area of ​​the drug-coated cloth, which is not conducive to the healing of the damaged surface of the patient and increases the pain of the patient.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0033] Example 1, 1) Preparation of Nocardia actinomyces cell wall skeleton

[0034] Take beef extract 4.0g, peptone 8.0g, sodium chloride 4.0g, agar 16.0g, glycerin 8.0ml, Na 2 HPO 4 12H 2 0.24g and 800ml of distilled water are prepared into glycerin agar medium, after sterilization at pH7.2-7.5, Nocardia actinomyces Nr-8026 CGMCCNo.0712 is inoculated in the medium, cultivated at 33°C for 5 days; Qualified strains were inoculated on glycerin medium after enrichment culture, and cultured at 33°C for 5 days. After the bacterial lawn was washed with sterile distilled water, the qualified bacterial solution was centrifuged at 3000rpm for 20 minutes, the collected bacteria were washed five times, combined and weighed for wet weight, and stored at -20°C. It is used by those who have no growth of miscellaneous bacteria through the pure-bred test. Take 1 weight of wet bacteria and 3 weights of sterile distilled water, mix them, vibrate, and then use an ultrasonic pulverizer to pul...

example 2

[0037]Example 2: 1) Under the same conditions as in Example 1, the cell wall skeleton of Nocardia rubrum was prepared for future use. 2) Preparation of the finished Nuoka ointment. a) Take 15 parts of cetyl alcohol and 40 parts of white petrolatum and heat and melt, adjust the temperature to 75°C and keep it warm; b) Take 5 parts of glycerin, 1 part of sodium lauryl sulfate and 0.2 parts of Ethyl hydroxybenzoate, add 38.8 parts of distilled water and heat to 80°C; c) Slowly add liquid a) into liquid b), and stir in the same direction as it is added, and continue stirring to 60°C, add 0.01 part of red promise Stir in the same direction until the cell wall skeleton of Actinomyces cardinosa is emulsified and condensed, and the final package is 10g / tube.

[0038] Example 3, 1) Under the same conditions as in Example 1, the cell wall skeleton of Nocardia rubrum was prepared for future use. 2) Prepare the finished Nuoka ointment: a) Take 22 parts of stearyl alcohol and 25 parts of ...

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PUM

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Abstract

The present invention relates to a medicinal preparation using extract of animal, plant or microbe as effective component, in particular it is a Nocar ointment for curing herpes simplex and herpes zoster. Its preparation method includes the following steps: firstly, culturing red nocardia CMGCC No.0712, enrichment culture, thallus collection, breaking cell, enzyme, purification to remove fat to obtain the effective component cell wall skeleton of said product, then according to mixing ratio of the formula adding ointment matrix sodium lauryl sulfate, octadecanol, white vaseline, liquid paraffin, ethyl-paraben, glycerine and monostearin and distilled water so as to obtain the invented product. Its cure rate is high, and its total effective rate is 100%.

Description

Technical field [0001] The present invention relates to a kind of pharmaceutical preparation which takes animal, plant or microorganism extract as active ingredient, especially Noka ointment for treating herpes simplex and herpes zoster. It is the preferred topical drug for patients with herpes simplex and herpes zoster. Background technique [0002] The incidence of viral skin diseases is increasing day by day, and herpes simplex and herpes zoster virus are quite common diseases among many viral skin diseases. Topical treatment of skin diseases plays an important role in the therapeutics of skin diseases, but there is no satisfactory topical drug for these two kinds of skin diseases. Some local anti-infection and damaged surface drugs are used for skin damage. These drugs usually only relieve symptoms but have no therapeutic effect on the intractable pain caused by herpes, so they often lead to Some patients left intractable neuralgia for several months after the skin les...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K35/74A61P31/22
Inventor 张策洪晓明王振波李军
Owner LIAONING GREATEST BIO-PHARM CO LTD
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