Method for separating lycoramine from plant extract

Abstract

The invention relates to a kind of effective constituent separation method in vegetation extract, especially the method of separating lycoramine from vegetation extract containing amaryllidaceae alkaloid. The industrial art is as follows: make vegetation extract containing amaryllidaceae alkaloid have pretreatment; adsorb and elute with cation exchange resin; track and detect the elution flowing composition; make the flowing composition in lycoramine have concentration and enrichment; after get virgin product of lycoramine free alkali, make it have recrystallization with organic solvent; finally, the lycoramine free alkali crystallization with about 99% purity can be acquired.

Description

(1) Technical field

[0001] The invention relates to a method for extracting effective medicinal components of plants, in particular to a method for separating ricolamine from other alkaloids from plant extracts containing Amaryllidaceae alkaloids. (2) Background technology

[0002] Lycoramine is a reversible acetylcholinesterase inhibitor, its action intensity is weaker than that of galantamine, and its acute toxicity is lower than that of galantamine, so its therapeutic index is close to or higher.

[0003] The structural formula of Likolamin is shown in the figure below.

[0004]

[0005] Ricolamine is extracted from natural plants. These plants are distributed in the fields of Amaryllis genus, Snowflake Narcissus, Manjusri, Narcissus, Tennis Flower, and Water Ghost Banana. Among them, Lycoris is representative. In the prior art, the method for isolating Ricolamin from plant extracts is mainly organic solvent extraction. Utilizing the properties that lipophilic alka...

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