Tissur engineering blood vessel and method of construction in vitro

Abstract

A histoengineered blood vessel features that its internal and external layers are made of the composite superfine fibre membrane and different cells are transplanted in different layers. Said composite superfine fibre membrane is composed of a core made of natural or artificial biodegradable material and the shell layer made of natural biodegradable material. Its external construction method includes such steps as preparing scaffold step by step, transplanting cells layer by layer, and integrally shaping.

Description

technical field

[0001] The invention relates to a tissue engineering blood vessel for medical use and an in vitro construction method thereof. More specifically, it relates to a tissue engineered blood vessel with a multi-layer composite ultrafine fiber structure and a bioactive component that can be released by using coaxial co-spinning technology. Background technique

[0002] Cardiovascular disease is one of the most serious diseases threatening human health. Defective and severely diseased blood vessels are generally transplanted and reconstructed. At present, nearly one million vascular reconstruction operations are performed every year in the world, and the clinically used vascular grafts include autologous, allogeneic, xenograft and artificial polymer blood vessels. Although these grafts have their own advantages, they all have defects such as insufficient donors, immune rejection, and thrombus formation. The development of tissue engineering has provided a new way ...