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Cucurbitacin soft capsule and its preparation process

A technology of cucurbitacin and soft capsule, applied in the field of medicine, can solve the problems of unsatisfactory treatment effect, long disintegration time of cucurbitacin tablets, low bioavailability, etc., shortens the disintegration time limit in vitro, is beneficial to oral administration and long-term storage , the effect of improving bioavailability

Inactive Publication Date: 2006-10-04
安徽省现代中药研究中心
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Each cucurbitacin tablet contains 0.1 mg cucurbitacin (containing 0.06 mg cucurbitacin B), but commercially available cucurbitacin tablets take a long time to disintegrate, have poor absorption, low bioavailability, and slow curative effect. Children, the elderly, bedridden patients and those who swallow Difficult patients are inconvenient to take, have poor compliance, and cannot obtain satisfactory therapeutic effects, so the existing dosage forms can no longer meet the clinical needs; Invention patent, cucurbitacin dripping pills (unlisted variety) is an immediate release preparation, the main components of cucurbitacin are CuB and CuE, and CuB is easy to be oxidized and decomposed, cucurbitacin tablets are coated with sugar or film to solve this problem, and Dropping pills can not solve this problem very well
Therefore the existing dosage form (listed varieties cucurbitacin tablets) can not meet the needs of various patients clinically, and therefore it is necessary to develop a new oral dosage form of cucurbitacin, i.e. cucurbitacin soft capsules, which can improve the oral The bioavailability can meet the needs of the majority of patients

Method used

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  • Cucurbitacin soft capsule and its preparation process
  • Cucurbitacin soft capsule and its preparation process
  • Cucurbitacin soft capsule and its preparation process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Component Quantity (g)

[0027] Cucurbitacin 0.1

[0028] soybean oil 30

[0029] Propylene Glycol 25

[0030] Tween-80 44.9

[0031] Made into 1000 capsules, each capsule contains cucurbitacin 0.1mg

[0032] Preparation process: the capsule shell of the cucurbitacin soft capsule contains 40% gelatin, 20% glycerin, 0.11% ethyl p-hydroxybenzoate, 1% titanium dioxide, 0.18% carbon black, and 38.71% water %, add an appropriate amount of gelatin into a stainless steel sol tank, then add an appropriate amount of water, seal it, and keep it warm at 70°C for 3 hours, then add the test amount of glycerin and preservatives, stir, vacuumize and degas for 2 hours, and put it in a gelatin insulation bucket Keep warm at 70°C overnight, and set aside; weigh the prescribed amount of soybean oil, propylene glycol and Tween-80, warm the above mixture to about 60°C while stirring, add the prescribed amount of cucurbitacin to dissolve it, and stir evenly Afterwards, it is compressed ...

Embodiment 2

[0034] Component Quantity (g)

[0035] Cucurbitacin 0.1

[0036] Polyethylene glycol 400 55

[0037] Glycerin 2.9

[0038] Tween-80 42

[0039]Made into 1000 capsules, each capsule contains cucurbitacin 0.1mg

[0040] Preparation process: Weigh the prescribed amount of polyethylene glycol 400, glycerin and Tween-80, warm the above mixture to about 60°C under stirring, add the prescribed amount of cucurbitacin to dissolve it, stir evenly and press into Soft capsules, packaged, ready to use.

Embodiment 3

[0042] Component Quantity (g)

[0043] Cucurbitacin 0.05

[0044] Polyethylene glycol 400 29

[0045] Propylene Glycol 25

[0046] Tween-80 46

[0047] Made into 1000 capsules, each capsule contains cucurbitacin 0.05mg

[0048] Preparation process: Weigh the prescribed amount of polyethylene glycol 400, propylene glycol and Tween-80, warm the above mixture to about 60°C under stirring, add the prescribed amount of cucurbitacin to dissolve it, stir evenly and press into Soft capsules, packaged, ready to use.

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Abstract

The invention relates to a cucurbitacin soft capsule oral medicament and process for preparation, wherein the medicament includes medicinal soup and capsule shell, wherein each tablet of the soup comprises micronized cucurbitacin 0.01-10mg, dissolvent and stabilizing agent, the shell contains gelatin, plasticizing agent, preservative agent, screening agent, flavoring agent and coloring matter.

Description

technical field [0001] The invention relates to a pharmaceutical preparation containing cucurbitacin with the functions of detoxifying, clearing away heat, promoting dampness and reducing jaundice, more specifically relates to a cucurbitacin soft capsule, and at the same time, the invention also relates to a preparation method of the pharmaceutical preparation. The invention belongs to the technical field of medicine. Background technique [0002] Cucurbitacin is the total cucurbitacin extracted from the melon pedicle of the Cucurbitaceae plant (Cucumis melo L.) by modern scientific methods, and then the effective monomer cucurbitacin B is separated and refined as the main component extract. It is a light yellow-white powder. Odorless, bitter taste, easily soluble in chloroform and ethyl acetate, soluble in methanol and acetone, slightly soluble in ethanol, almost insoluble in water and petroleum ether. Cucurbitacin has the effects of detoxifying, clearing away heat, promot...

Claims

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Application Information

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IPC IPC(8): A61K31/57A61K9/48A61P1/16A61P31/14
Inventor 刘光东胡容峰李华王琳琳陈光亮徐希平
Owner 安徽省现代中药研究中心
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