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Application of hydroxybenzoate acid and its analogue in the preparing process of medicine for preventing and treating virus infection

A technology of hydroxybenzoate and trihydroxybenzoate, which is applied in the field of application of hydroxybenzoate and its analogs in the preparation of drugs for the prevention and treatment of viral infections, and can solve the problem of high toxicity and long-term Medication, short-term application only has temporary effect, etc.

Active Publication Date: 2007-02-07
SHENGHUA GUANGZHOU PHARMA SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Antiviral drugs for hepatitis B virus (HBV), vidarabine, vidarabine phosphate, acyclovir, and zidovudine, which were tested in the 1980s, have been used abroad because of their poor efficacy and high toxicity. no longer used to treat hepatitis B
In recent years, a variety of nucleoside drugs have been developed, which have obvious inhibitory effects on HBV, such as lamivudine, famciclovir, lobucavir, adefovir, FTC, FMAU, FDDC, BMS200475, etc., but long-term application For these drugs, the virus may mutate and be resistant, and long-term medication is required, and short-term application has only temporary effects

Method used

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  • Application of hydroxybenzoate acid and its analogue in the preparing process of medicine for preventing and treating virus infection
  • Application of hydroxybenzoate acid and its analogue in the preparing process of medicine for preventing and treating virus infection
  • Application of hydroxybenzoate acid and its analogue in the preparing process of medicine for preventing and treating virus infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] The preparation of embodiment 1 anti-HPV virus microemulsion

[0048] Take 20ml of 1,2-propanediol, 15ml of Tween 80, and 5ml of azone, mix them, add sterilized distilled water until the total volume is 100ml, and obtain an external preparation solution. Take benzoic acid, salicylic acid, benzoic acid + salicylic acid, p-hydroxybenzoic acid, 2,3-dihydroxybenzoic acid, 2,4-dihydroxybenzoic acid, 3,4-dihydroxybenzoic acid, p-hydroxybenzoic acid Ethyl formate, methyl 3,4-dihydroxybenzoate, gallic acid, lauryl gallate, octyl gallate, propyl gallate, ethyl gallate, methyl gallate, 2,4-bis Each 10g of methyl hydroxybenzoate, respectively add external preparation solution 50ml, adjust pH to 5.5, then add external preparation solution to 100ml, get 10% anti-HPV virus microemulsion of the present invention and control group microemulsion.

Embodiment 2

[0049] Example 2 Preparation of anti-HBV virus propyl gallate injection

[0050] Take 10g of propyl gallate, 8.5g of sodium chloride, 10ml of 1,2-propanediol, and 10ml of Tween 80, mix them, add sterilized distilled water to dissolve, and add sterilized distilled water to 100ml, adjust the pH to 7.4, filter , potted, and sterilized at 100°C for 30 minutes. Propyl gallate injection was obtained.

Embodiment 3

[0051] Example 3 Preparation of Compound Ethyl Gallate Effervescent Tablets

[0052] Take 0.25g of ethyl gallate, 0.01g of polymyocytes, and 0.45g of tartaric acid to pass through a 80-mesh sieve respectively, make a soft material with 95% ethanol, pass through a 12-mesh sieve to make wet granules, dry at 50°C, and set aside. Separately take 0.65g of sodium bicarbonate, 0.02g of dextrin and add sterile distilled water to make soft materials, pass through a 12-mesh sieve to make wet granules, dry at 50°C, then mix with the above-mentioned dry granules, granulate, add appropriate amount of sterilized distilled water, and dry After a while, add 0.01g PEG6000. Mix well, press into tablets, and get ready.

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Abstract

The invention relates to the use of hydroxybenzoate and analogues in preparing medicament for the prevention or treatment of viral infections, especially for preparing medicament for treating human and animal HBV, HPV and HSV.

Description

technical field [0001] The present invention relates to the application of hydroxybenzoate and its analogs in the preparation of drugs for the prevention and treatment of viral infections, such drugs can be used for the treatment of human and animal HBV, HPV, HSV viral diseases, such as hepatitis B, Condyloma, herpes simplex, vagina, cervicitis and cervical erosion and adjuvant treatment of cervical cancer. Background technique [0002] Among hydroxybenzoates and their analogs, parabens are known to be used as preservatives in food and medicine; gallate (3,4,5-trihydroxybenzoate) can inhibit blood clots Synthesized by A2 (TXA2), which has a stronger and faster anti-platelet aggregation effect than aspirin (ASP), and has been used to prepare injections; gallic acid has been proven to have an inhibitory effect on hepatitis B HBV virus (Guangzhou Medical Sciences of the PLA Journal of Higher Technical Colleges, 1998, 26(2):5-7). So far there is no relevant hydroxybenzoate and...

Claims

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Application Information

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IPC IPC(8): A61K31/216A61K9/00A61K9/12A61K8/37A61Q19/10C11D3/48A61P31/12A61P31/14A61P35/00A61P1/16
CPCA61K9/0014A61K9/0007A61K9/0019A61K9/1075A61K31/215A61K31/216A61P15/00A61P15/02A61P17/00A61P31/12A61P31/14A61P31/20A61P31/22A61P35/00A61P9/12A61K31/222
Inventor 张庆民秦卫华
Owner SHENGHUA GUANGZHOU PHARMA SCI & TECH
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