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Compound medicament composed of gastrodine and ligustrazine

A technology of ligustrazine and gastrodin, which is applied in the field of medicine and achieves the effects of good clinical treatment effect, low incidence and few adverse reactions

Inactive Publication Date: 2007-04-25
JIANGSU CAREFREE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Modern pharmacological studies have proved that gastrodin is an active ingredient of gastrodia elata, and ligustrazine is an effective ingredient of ligustra chuanxiong. Relevant reports on the use of side compatibility

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] The ratio of gastrodin: ligustrazine is (0.1-100): 1, and an appropriate amount of dressing forming agent is added according to the requirements of each oral dosage form to prepare tablets, capsules, soft capsules, microcapsules, granules, etc.

[0040] Take gastrodin: Ligustrazine ratio is (0.1-100): 1, add appropriate dressing diluent, adhesive, disintegrant and lubricant, diluent can be starch, dextrin, powdered sugar, lactose, mannitol, One or more of calcium sulfate, calcium hydrogen phosphate, etc., the binder can be one or more of water, ethanol, starch slurry, dextrin, powdered sugar and syrup, mucilage, cellulose derivatives, etc. The disintegrant can be starch and its derivatives, cellulose, surfactants, etc. The lubricant can be stearic acid, calcium stearate, magnesium stearate, PEG4000, PEG6000, sodium benzoate, sodium lauryl sulfate, One or several kinds of lauryl magnesium sulfate, refined talc powder, micropowder silica gel, etc., can also add appropriat...

Embodiment 2

[0047] Take ligustrazine, grind finely, add 30-70 times of water for injection and stir to dissolve completely, and set aside; take gastrodin plus 10-20 times of water for injection to dissolve, slowly add the above aqueous solution of ligustrazine, stir, and add to isotonic volume The osmotic pressure regulator is used to dissolve; through membrane ultrafiltration, potting and sealing into injection or infusion, and sterilization, injection and infusion preparations are obtained. The osmotic pressure regulator mentioned above is one or more of mannitol, sodium chloride or glucose.

[0048] or

[0049] Take ligustrazine, grind finely, add water for injection and stir to dissolve completely, set aside; take gastrodin and dissolve with water for injection, slowly add the above aqueous solution of ligustrazine, stir, dissolve; add molding agent to dissolve; dilute with appropriate amount of water for injection , and stir evenly; through membrane ultrafiltration, the ultrafiltrat...

Embodiment 3

[0050] Embodiment 3: the preparation of injection

[0051] Take Ligustrazine 20g, grind finely, add 1000ml water for injection to dissolve completely. Take gastrodin raw material 200g and add 2-4L water for injection to dissolve. Slowly add the aqueous solution of ligustrazine to the aqueous solution of gastrodin, stir until clear while adding, and dilute to 10L with water for injection. The medicinal liquid is ultrafiltered through an ultrafiltration membrane with a pore size of 10,000 molecular weight, potted, 10 ml / bottle, and sterilized to obtain an injection.

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PUM

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Abstract

The invention relates to a compound medicament which comprises gastrodine and ligustrazine by the weight ratio of (0.1-100) : 1, and can be used for the synergic increase blood flow of coronary artery and brain. The medicament can be used for the treatment of nervous prostration syndrome, brain trauma syndrome, megrims, nerve pain, cephalalgia, cerebral embolism, cerebral hemorrhage, coronary disease, angina pectoris and myocardial infarction.

Description

technical field [0001] The invention relates to a compound medicine for treating cardiovascular, cerebrovascular and neurological diseases, which is composed of gastrodin and ligustrazine in a certain proportion, and belongs to the technical field of medicine. Background technique [0002] Cardiovascular and cerebrovascular diseases are the number one killer that endangers human life and health. According to the latest statistics, 17 million people died of cardiovascular diseases in the world in 2000, accounting for 1 / 3 of the total number of deaths from various causes in the world. It is estimated that by 2020 This number will increase to 25 million in 2010, 80 percent of which will be in developing countries. [0003] According to the analysis of the causes of death in my country in 1997, among the causes of death among urban population, tumors accounted for the first place, and cerebrovascular diseases accounted for the second place. Disease takes second place. Ischemic ...

Claims

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Application Information

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IPC IPC(8): A61K31/7034A61K31/4965A61K9/16A61K9/20A61K9/48A61K9/14A61K9/08A61P25/20A61P25/04A61P9/10
Inventor 秦引林何龙其
Owner JIANGSU CAREFREE PHARM CO LTD
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