Method and composition for resuscitation

Abstract

The key obstacle for current resuscitation is the acutely limited time window. The major reason for the limited time window is that the brain is extremely vulnerable to hypoxic-ischemic insult. The existence of cerebrospinal fluid (CSF) is the major reason why brain and spinal cord is so vulnerable. A method and a composition for resuscitation of cardiac arrest are provided. The method includes steps of inhibiting CSF production, removing CSF or replacing the CSF with invented composition plus conventional CPR. The composition includes colloidal osmotic agent, insulin, elevated magnesium concentration and ATP in artificial CSF.

Description

BACKGROUND OF THE INVENTION [0001] 1. Field of the Invention [0002] This invention is related to a method and a medical composition for resuscitation. In particular, the invention relates to protection of the brain and spinal cord during resuscitation of cardiac arrest. This patent is a continuation of my previous patient application. [0003] 2. Background Information [0004] It is estimated that more than 350,000 Americans died of sudden cardiac arrest each year, more than 95 percent of victims die before reaching the hospital. Economic costs for trauma related arrest is over 400 billion dollars each year. Despite numerous scientific advances throughout modern medicine, outcome of resuscitation for arrest victims remains poor, and outcomes in trauma related battlefield statistics have not improved significantly since the Civil War. The cardiopulmonary resuscitation (CPR) practice including ventilation, closed chest compressions or cardiac massage and defibrillation (step ABC, i.e. Ai...

AI Technical Summary

Benefits of technology

[0020] I have found removing the CSF from subarachnoid spaces can effectively prolong the time window for conventional CPR procedure. I have found that replacing the CSF with the invented composition also can effectively prolong the time window for conventional CPR procedure. To use the method to rescue a cardiac arrest patient, first injecting Furosemide or Acetazolamide to stop CSF production, then the CSF will be removed completely from subarachnoid spaces as early as possible, it is preferable that the removal of the CSF start even before conventional CPR. The CSF removal eliminates the major source of water causing cerebral edema, and prevents the onset of the “no-reflow” phenomenon or “hypoperfusion”, making CNS tissue resistant to ischemia, and lengthening the therapeutic window for resuscitation. This method is especially suitable for out-of-hospital application before the patient can be transferred to a medical center. The CSF drainage was first used to prevent spinal cord damage during thoracic aorta surgery in 1957 by a group of Japanese surgeons (Miyamoto K, et al, J cardiovasc surg. 1960; 16: 188-197). More than 45 years of experiences have proven that CSF drainage is the most effective way to prevent paraplegia in majority of the cases. However, some medical centers also reported failure to prevent paraplegia by CSF drainage (Crawford E S et al, J Vasc Surg. 1991; 13(1): 36-46). I have proven that the CSF is so toxic that a small amount of CSF left in subarachnoid space can damage the local tissue and significantly influence the outcome (I believe ...

Problems solved by technology

However, CPR procedures lack an important step of protecting brain, therefore the time window for resuscitation is the acutely limited.

In clinic, the real problem in resuscitating a patient with circulatory arrest is usually not to restore cardio-pulmonary function but instead to prevent “brain death”.

The CNS tissue including brain and spinal cord is very vulnerable to hypoxia-ischemia, the reason for this has not been clear, and no effective approaches has been available to protect brain and spinal cord.

The CSF is very prone to edema because it lacks macromolecules due to the brain-CSF barrier.

Cardiac arrest results in complete cerebral ischemia, this...