Construction of Arterial Occlusive Disease Animal Model

a construction and occlusive disease technology, applied in educational models, medical science, diagnostics, etc., can solve the problems of high mortality within a relatively short period, lack of stable pathologic conditions, and high probability of death, and achieve stable pathologic conditions, low animal mortality, and high certainty of vascular embolism.
US20080295189A1Inactive Publication Date: 2008-11-27HEALTH SCI TECH TRANSFER CENT JAPAN HEALTH SCI FOUND
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
HEALTH SCI TECH TRANSFER CENT JAPAN HEALTH SCI FOUND
Publication Date
2008-11-27
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to a method for generating a non-human model animal of an arterial occlusive disease, wherein the method is characterized in that an artery is occluded at a specific site by ligating it or with an autologous blood clot. In particular, the present invention relates to a method and a kit for generating a cardiac infarction model, as well as a cardiac infarction animal model obtained by employing the method or kit, characterized in that in a non-human experimental animal, a blood vessel is ligated downstream of an arterial site of the heart to be occluded, followed by occluding the artery at said site. In addition, the present invention also relates to a method and a system for generating a non-human animal model of arterial embolus, as well as an arterial embolus animal model obtained by employing the method or system, characterized by adding an coagulating agent to autologous blood to form an autologous blood clot and subsequently employing an angiographic apparatus in delivering the autologous blood clot into an artery.
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Description

TECHNICAL FIELD

[0001] The present invention relates to a method and a kit or a system for generating a model animal of an arterial occlusive disease, as well as an arterial embolus animal model obtained by the method or system. Specifically, the present invention relates to a method and a kit or a system for generating a non-human model animal of an arterial occlusive disease, as well as an arterial embolus animal model obtained by the method or system, characterized by occluding an artery at a specific site by ligating it or with an autologous blood clot.BACKGROUND ART

[0002] In the past, a number of models of heart diseases such as cardiac infarction has been used in medical studies, for example, of the circulatory system and in organ transplantation, or alternatively in the development of medicaments for circulatory system diseases. Recently, these models of heart diseases also have become utilized in studies on regenerative medicine.

[0003] Regarding conventional models of cardiac in...

Claims

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