Biodegradable elastomers prepared by the condensation of an organic di-, tri- or tetra-carboxylic acid and an organic diol
a technology of organic diol and organic diol, which is applied in the field of biodegradable and biocompatible poly (alkylene carboxylate) thermoset based elastomeric materials, can solve the problems of undesirable heterogeneous degradation, outperform thermoplastics, and slow rate of bioabsorption
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example 1
Preparation of 1:1 poly(1,8-octanediol-L-tartaric)ester (POT) condensation polymer
[0150]Solvent free polymerization was carried out in a three neck round bottom flask equipped with a condenser, gas inlet and a magnetic stirrer. Into the flask, and under argon atmosphere, a 1:1 molar ratios of L-tartaric acid (0.105 M) and 1,8-octanediol (0.105 M) and an amount of SnOct equivalent to 1.4×10−4 mol for each 1 mol of the monomer were transferred, mixed and heated at 140° C. using silicone oil bath for 1 hour. The reaction was then run under vacuum for 2 more hours. The resulting molten mass of the prepared crude condensation polymer was then dissolved in chloroform, filtered, precipitated in cold anhydrous ethyl ether, and dried under vacuum overnight. The final product was characterised using Nuclear Magnetic Resonance (NMR), Mass Spectroscopy (MS), Fourier Transform Infra Red Spectroscopy (FT-IR), Gel Permeation Chromatography (GPC) and Differential Scanning Calorimetry (DSC).
[0151]Th...
example 2
Synthesis of the Elastomeric Polymer
[0156](a) Procedure: The following procedure describes the steps involved in preparing the elastomer using a 4:1 weight ratio of POT:BCP respectively, as seen in FIG. 1. In a dry silanized glass ampoule, 1 g of BCP was left in the preheated oven for 5-10 minutes to melt at 160° C. A molten mass of 4 g polyester condensation polymer (POT) and an amount of SnOct equivalent to 1.4×10−4 mol for each 1 mol of the monomer were added to the ampoule. The content was mixed using a vortex mixer and the ampoule was sealed under vacuum. The ampoule was then left in the vacuum oven at 120° C. for 1 hour and then the seal was broken and the highly viscous liquid was poured into rectangular Teflon moulds (100×6×3 mm), covered, left in the vacuum oven at 120±5° C. under 10 mmHg vacuum for 18 hours. The elastomeric slabs were then removed from the mould and characterized using DSC, FT-IR and in vitro degradation and tensile testing before and during the degradatio...
example 3
In Vitro Degradation Studies
[0164](a) Procedures: Slab specimens of Elast 1 and Elast 2 of the prepared elastomers reported in Table 1 were subjected to an in vitro degradation study. Each specimen was transferred into 15 ml tissue culture tube containing 12 ml of 1 / 15 M Phosphate Buffer Saline (PBS) at pH 7.4. The tubes were then attached to a Glas-Col's rugged culture rotator. The rotator was set at 30% rotation speed and placed in an oven at 37° C. The buffer was replaced on daily basis to ensure a constant pH of 7.4 during the whole period of the study. One set of samples representing each ratio was left without changing its buffer to monitor the change in the medium's pH with respect to time. The specimens were then dried, weighted and subjected to tensile testing at time periods of 0, 1, 2, 4, 6 and 8 weeks.
[0165]Mass loss over 0, 1, 2, 4, 6 and 8 weeks was calculated using the following formula: Mass loss=[(G1−G2) / G1]×100%, where G1 is the initial weight of the slab before de...
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