Composition for treating atherosclerosis and a preparation method thereof

Abstract

Disclosed are a composition for preventing and treating atherosclerosis which includes chalcone compound. In particular, the chalcone compound bound with 2-hydroxyl in ring A and 4′-methyoxy in ring B has versatile therapeutic potentials on anti-atherosclerosis by acting as PPARγ inducer, p44 / 42 MAPK inhibitor and cell cycle blocker and does not show toxicity to human aortic smooth muscle cells (HASMCs). In addition, the chalcone compound exhibits synergistic effect with the PPARγ ligand (rosiglitazone) to inhibit cell proliferation and the upregulation of cyclin D1, cyclin D3, interleukin-1β (IL-1β) and interleukin-6 (IL-6) induced by oxidized low density lipoprotein (Ox-LDL).

Description

CROSS-REFERENCE TO RELATED APPLICATION AND CLAIM OF PRIORITY[0001]The application claims the benefit of Taiwan Patent Application No. 100128614, filed on Aug. 10, 2011, in the Taiwan Intellectual Property Office, the disclosures of which are incorporated herein in their entirety by reference.FIELD OF THE INVENTION[0002]The present invention relates to a chalcone composition and the preparation method thereof. In particular, the present invention relates to a composition for preventing and treating atherosclerosis and the preparation method thereof.BACKGROUND OF THE INVENTION[0003]Cardiovascular disease is a symptom of heart and blood vessels. Cardiovascular disease can be grouped as coronary artery heart disease, cerebrovascular disease, peripheral arterial occlusion disease, rheumatic heart disease, congenital heart disease, deep vein thrombosis and pulmonary embolism. Ischemic heart disease, myocardial infarction or sudden death will be induced if coronary arteriosclerosis occurs....

AI Technical Summary

Benefits of technology

The patent is about a substance that increases the amount of a protein called PPARγ. This substance can be translated from a specific type of RNA. The technical effect of this is that it helps to increase the amount of PPARγ in the body, which can have beneficial effects on certain medical conditions.

Problems solved by technology

The occurrence of cerebral or carotid arteriosclerosis will result in renal hypertension and even uremia.

However, the side effect of stomach upset (diarrhea or constipation) might occur.

Nevertheless, the side effects such as stomach upset, hyperuricacidemia, gout, exanthema and the upgrade of liver function indexes and so on would occur.

Its chemical structure is similar to that of vitamin K, and its functional mechanism is to counteract the activity responses of vitamin K-dependent coagulation factors II, VII, IV and X. However, Vitamin K antagonist will result in the side effects such as hematuria, gastrointestinal bleeding, intracerebral hemorrhage and so on.

However, heparin might generate the side effects such as bleeding, hypersensitivity, platelet deficiency disease and so on.

Although hirudin is the most effective natural anticoagulant, it is difficult to extract it from leeches and hirudin must be prepared with the recombinant biotechnology.

Since aspirin will reduce the secretion of protection materials in stomach, so that side effects, e.g. stomach upset, gastrointestinal bleeding and so on, would occur.

Among ADP receptor inhibitors, Clopidogrel would have the risk of stomach bleeding.

Thus, Cilostazol has the functions of anti-platelet aggregation and angiectasis, but results in side effects such as headache, diarrhea, vomit, erythematous rash, and hematological abnormality, etc.

When dipyridamole is administered with heparin, bleeding risk would be increased.

Among thromboxane inhibitors, Terutroban can block platelet aggregation and vasoconstriction induced by thromboxane, promote endoderm's functions and has anti-atherosclerosis effect, whereas it also has the bleeding risk.

Thrombolytic agent is suitable for treating deep vein thrombosis, pulmonary embolism, acute myocardial infarction and acute arterial embolism, but it will result in bleeding and hypersensitivity.

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