Microorganisms and methods for production of specific length fatty alcohols and related compounds

a technology of fatty alcohol and microorganisms, applied in the direction of acyltransferases, dna/rna fragmentation, enzymes, etc., can solve the problems of not producing high yields of fatty alcohol, not commercially viable to produce fatty alcohol directly, and not producing fatty alcohol. achieve the effect of increasing the ratio of nad(p)h to nad(p)
US20150275242A1Inactive Publication Date: 2015-10-01GENOMATICA INC
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
GENOMATICA INC
Publication Date
2015-10-01
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides non-naturally occurring microbial organisms containing a fatty alcohol, fatty aldehyde or fatty acid pathway, wherein the microbial organisms selectively produce a fatty alcohol, fatty aldehyde or fatty acid of a specified length. Also provided are non-naturally occurring microbial organisms having a fatty alcohol, fatty aldehyde or fatty acid pathway, wherein the microbial organisms further include an acetyl-CoA pathway. In some aspects, the microbial organisms of the invention have select gene disruptions or enzyme attenuations that increase production of fatty alcohols, fatty aldehydes or fatty acids. The invention additionally provides methods of using the above microbial organisms to produce a fatty alcohol, a fatty aldehyde or a fatty acid.
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Description

[0001] This application claims the benefit of priority of U.S. Provisional application Ser. No. 61 / 714,144, filed Oct. 15, 2012, the entire contents of which is incorporated herein by reference.BACKGROUND OF THE INVENTION

[0002] The present invention relates generally to biosynthetic processes, and more specifically to organisms having specific length fatty alcohol, fatty aldehyde or fatty acid biosynthetic capacity.

[0003] Primary alcohols are a product class of compounds having a variety of industrial applications which include a variety of biofuels and specialty chemicals. Primary alcohols also can be used to make a large number of additional industrial products including polymers and surfactants. For example, higher primary alcohols, also known as fatty alcohols (C4-C24) and their ethoxylates are used as surfactants in many consumer detergents, cleaning products and personal care products worldwide such as laundry powders and liquids, dishwashing liquid and hard surface cleaners. The...

Claims

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