Organic/inorganic hybrid-biodegradable porous polymer scaffolds and preparation method thereof

Abstract

Provided is an organic / inorganic hybrid-porous biodegradable polymer scaffold, which includes basic ceramic nanoparticles, an animal tissue or cell-derived bioactive first extracellular matrix material, and a biodegradable polymer and in which inner walls of pores are coated with a second extracellular matrix material.

Description

CROSS-REFERENCE TO RELATED APPLICATION[0001]This application claims priority to and the benefit of Korean Patent Application No. 2016-0143469, filed on Oct. 31, 2016, the disclosure of which is incorporated herein by reference in its entirety.BACKGROUND1. Field of the Invention[0002]The present invention relates to an organic / inorganic hybrid-porous biodegradable polymer scaffold prepared by having ceramic nanoparticles having excellent bioactivity and mechanical properties and an extracellular matrix material bulk-mixed with a biodegradable polymer and coating the mixture on the scaffold surface and a method for preparing the same, and more particularly, to a hybrid scaffold for tissue regeneration, in which a biodegradable polymer scaffold includes basic ceramic nanoparticles having a high dispersion property and high stability and a bioactive material derived from the extracellular matrix of a target tissue, and a porous surface is coated with an extracellular matrix-based materi...

AI Technical Summary

Benefits of technology

The present invention provides a highly functional hybrid scaffold that can be used as a polymer scaffold, containing prepared basic ceramic nanoparticles and an extracellular matrix material with adjustable shapes and sizes. The scaffold can be biodegradable and has controllable inflammatory response, cell adhesion, tissue regeneration, and mechanical strength. The invention also provides a simple and efficient method to prepare an organic / inorganic hybrid scaffold that can overcome the limitations of pure synthetic and natural polymer scaffolds.

Problems solved by technology

However, such biodegradable polymers have relatively poor physical properties in compared to other general-purpose polymers and generate acidic materials such as lactic acid, glycolic acid, hydroxycaproic acid, maleic acid, phosphazene, hydroxybutyric acid, ethoxyacetic hydroxide, sebacic acid, alcohol, trimethylene glycol, amino acid, formalin, and alkylcyanoacrylate through biodegradation, thereby causing inflammatory response and cytotoxicity in the human body.

Also, to overcome the limitations in biocompatibility and tissue regeneration capability of the synthetic polymer material as a biomedical implant, recently, development of a scaffold for tissue regeneration using a natural polymer and an extracellular matrix has been suggested by several researchers (for example, Korean Unexamined Patent Application Publication No. 10-2010-0041027), but the scaffold lacks good physical and mechanical properties, has a difficulty with controlling degradation duration, has a limitation in chemical modification due to low solubility in an organic solvent, and cannot be applied in various forms.

However, these methods are complicated and time-consuming and have limitations in unintentionally changing properties such as changing a specific physical property in the case of a polymer having a low molecular weight and reducing a pore size after surface coating scaffold pores, in particular.