Organic/inorganic hybrid-biodegradable porous polymer scaffolds and preparation method thereof

Abstract

Provided is an organic/inorganic hybrid-porous biodegradable polymer scaffold, which includes basic ceramic nanoparticles, an animal tissue or cell-derived bioactive first extracellular matrix material, and a biodegradable polymer and in which inner walls of pores are coated with a second extracellular matrix material.

Description

CROSS-REFERENCE TO RELATED APPLICATION[0001]This application claims priority to and the benefit of Korean Patent Application No. 2016-0143469, filed on Oct. 31, 2016, the disclosure of which is incorporated herein by reference in its entirety.BACKGROUND1. Field of the Invention[0002]The present invention relates to an organic / inorganic hybrid-porous biodegradable polymer scaffold prepared by having ceramic nanoparticles having excellent bioactivity and mechanical properties and an extracellular matrix material bulk-mixed with a biodegradable polymer and coating the mixture on the scaffold surface and a method for preparing the same, and more particularly, to a hybrid scaffold for tissue regeneration, in which a biodegradable polymer scaffold includes basic ceramic nanoparticles having a high dispersion property and high stability and a bioactive material derived from the extracellular matrix of a target tissue, and a porous surface is coated with an extracellular matrix-based materi...

AI Technical Summary

Benefits of technology

[0011]To overcome the limitations of the conventional art described above, the present invention is directed to providing a highly functional hybrid scaffold, which serves as a polymer scaffold constituting a main matrix whose pore size and density, and porosity may be adjusted, as a polymer scaffold containing prepared basic ceramic nanoparticles and an extracellular matrix material with adjustable shapes and sizes, and as a...

Problems solved by technology

However, such biodegradable polymers have relatively poor physical properties in compared to other general-purpose polymers and generate acidic materials such as lactic acid, glycolic acid, hydroxycaproic acid, maleic acid, phosphazene, hydroxybutyric acid, ethoxyacetic hydroxide, sebacic acid, alcohol, trimethylene glycol, amino acid, formalin, and alkylcyanoacrylate through biodegradation, thereby causing inflammatory response and cytotoxicity in the human body.

Also, to overcome the limitations in biocompatibility and tissue regeneration capability of the synthetic polymer material as a biomedical implant, recently, development of a scaffold for tissue regeneration using a natural pol...