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Pharmaceutical compositions

a technology of pharmaceutical compositions and compositions, applied in the field of pharmaceutical compositions, can solve the problems of skin cancer, damage to epidermal and dermal layers, and the size of the dermis layer, and achieve the effect of optimal skin penetration and stabilization of vitamin d3

Inactive Publication Date: 2020-02-13
JOYDERMA AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The invention is a new composition that includes a combination of vitamin D3 or a precursor thereof, and hyaluronic acid or a derivatives thereof. The vitamin D3 is stabilized and protected from degradation reactions by being encapsulated in a lipid based colloidal carrier system. This allows the vitamin D3 to penetrate into the upper layers of the skin and exert its activity after being converted into the active form upon UVA and UVB exposure. The technical effect of this composition is an improved skin penetration and stability of the vitamin D3, which leads to increased efficiency and effectiveness in skincare products.

Problems solved by technology

UVB with a wavelength of 280-315 nm provides the energy the skin needs to make vitamin D3, but is also a primary mutagen that penetrates through the epidermal layer of the skin, resulting in DNA mutations, potentially leading to skin cancer (non melanoma skin cancer (NMSC) and melanoma).
UVA with a wavelength of 315-400 nm is able to penetrate deeper into the skin as compared to UVB rays and thus may damage both the epidermal and dermal layers.
With constant UVA exposure, the size of the dermis layer will be reduced, causing an atrophy of the skin.
This and other findings suggests that serum calcidiol might be associated with an increased risk of aging-related chronic diseases including cancer.

Method used

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  • Pharmaceutical compositions
  • Pharmaceutical compositions
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Examples

Experimental program
Comparison scheme
Effect test

example 1

without UV-Filter System Cream

[0080]

TABLE 4QuantityIngredients (INCI)wt %CAS-No.7-DHC0.15434-16-2HA39004-61-9Retinyl Palmitate0.579-81-2SkinConditioningRiboflavin0.183-88-5Niacinamide4.098-92-0Dexpanthenol2.581-13-0Folic acid0.0559-30-3L-ascorbic acid3.050-81-7Tocopheryl Acetate2.07695-91-2Aqua destillata46.1967732-18-5SolventPEG-5 Glyceryl Stearate1.051158-08-8Surfactant138860-92-1Stearic Acid1.057-11-44Emulsifying EmolientIsopropyl Myristate1.0110-27-0Palmitic Acid1.057-10-3Lupinus albus Ölextrakt2.0545-47-1Palmitoyl-Pentapeptid1.0214047-00-4Prunus amygalus dulcis oil5.08007-69-0 / 90320-37-9Squalene1.0111-02-4Polidocanol3.03055-99-0Hydroxypalmitoylsphinganin1.0190249-36-6Pyridoxine HCL5.08007-69-0 / Conditioning90320-37-9ConservantSodium Ascorbyl Phosphate2.066170-10-3Sodium Citrate1.06132-04-3BufferLecithin28002-43-5Carrierencapsulationformulary*Sphingomyeline285187-10-6Linolenic Acid1463-40-1Linoleic Acid160-33-3Phosphatidylcholin326853-31-6Caprylic Triglyceride173398-61-5Octyldode...

example 2

without UV-Filter System Gel

[0081]

TABLE 5QuantityIngredients (INCI)wt %FunctionCAS-No.7-DHC0.15Active ingredient434-16-2ROS binderHA3Active ingredient9004-61-9HumectantRetinyl Palmitate0.5Skin Conditioning79-81-2Riboflavin0.1Skin Conditioning83-88-5Niacinamide4.0Skin Conditioning98-92-0Dexpanthenol2.5Skin Conditioning81-13-0Folic acid0.05Skin Conditioning59-30-3L-ascorbic acid3.0Skin Conditioning50-81-7Tocopheryl2.0Skin Conditioning7695-91-2AcetateAqua destillata65.77Solvent7732-18-5Stearic Acid1.0Surfactant57-11-44Isopropyl1.0Emulsifying Emolient110-27-0MyristatePalmitic Acid1.0Emulsifying Emolient57-10-3Cetearyl Alcohol1.0Emulsifying Emolient67762-27-0 / 8005-44-5Polidocanol2.0Emulsifying Emolient3055-99-0Sodium Citrate1.0Buffering6132-04-3Lecithin1Carrier encapsulation8002-43-5formulary*Sphingomyeline2Carrier encapsulation85187-10-6formulary*Linolenic Acid1Carrier encapsulation463-40-1formulary*Linoleic Acid1Carrier encapsulation60-33-3formulary*Phosphatidylcholin2.0Carrier encapsu...

example 3

without UV-Filter System Serum

[0082]

TABLE 6QuantityIngredients (INCI)wt %FunctionCAS-No.7-DHC0.15Active434-16-2ingredientROS binderHA3Active9004-61-9ingredientHumectantDexpanthenol2.5Skin81-13-0ConditioningFolic acid0.05Skin59-30-3ConditioningTocopheryl Acetate2.0Skin7695-91-2ConditioningAqua destillata70.3Solvent7732-18-5PEG-5 Glyceryl Stearate1.0Surfactant51158-08-8138860-92-1Stearic Acid1.0Surfactant57-11-44Isopropyl Myristate1.0Emulsifying110-27-0EmolientPalmitic Acid1.0Emulsifying57-10-3EmolientPalmitoyl-Pentapeptid1.0Emulsifying214047-00-4EmolientPolidocanol2.0Emulsifying3055-99-0EmolientHydroxypalmitoylsphinganin1.0Emulsifying190249-36-6EmolientSodium Citrate1.0Buffering6132-04-3Lecithin1Carrier8002-43-5encapsulationformulary*Sphingomyeline2Carrier85187-10-6encapsulationformulary*Linolenic Acid1Carrier463-40-1encapsulationformulary*Linoleic Acid1Carrier60-33-3encapsulationformulary*Phosphatidylcholin3Carrier26853-31-6encapsulationformulary*Caprylic Triglyceride1Carrier73398-6...

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Abstract

A composition including a synergistic combination of a vitamin D3 or a derivative or precursor thereof and hyaluronic acid or derivate thereof encapsulated in a lipid based colloidal carrier system (preferably lipid based vesicles such as liposomes, niosomes, tranferosomes) and topical formulations thereof, as well as their use in the prevention and / or treatment of inflamed skin and mucous membrane, especially in the prevention and / or treatment of skin photodamage, in particular in the prevention and / or treatment of skin erythema (skin inflammation) and actinic keratosis, as well non melanoma skin cancer.

Description

BACKGROUND OF THE INVENTIONField of the Invention[0001]The present invention is directed towards new compositions comprising a synergistic combination of a vitamin D or a derivative or precursor thereof and hyaluronic acid or derivate thereof encapsulated in a lipid based colloidal carrier system (preferably lipid based vesicles such as liposomes, niosomes, tranferosomes) and topical formulations thereof, as well as their use in the prevention and / or treatment of inflamed skin and mucous membrane, especially in the prevention and / or treatment of skin photodamage, in particular in the prevention and / or treatment of skin erythema (skin inflammation) and actinic keratosis, as well non melanoma skin cancer.Discussion of Related Art[0002]Skin disorders according to ICD-10 (International Classification of Diseases, Version 2016) include (a) group of conditions in which the skin becomes inflamed, forms blisters, and becomes crusty, thick, and scaly (including eczema causing burning and itc...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K8/73A61K8/34A61K8/63A61K8/14A61Q17/04
CPCA61Q17/04A61K8/63A61K8/14A61K8/347A61K8/735A61K8/67A61K8/671A61K8/673A61K8/676A61K8/678A61Q19/007A61K9/0014A61K47/14A61K47/24A61K9/1075A61K9/127A61K8/11A61K31/07A61K31/197A61K31/355A61K31/375A61K31/455A61K31/519A61K31/525A61K31/592A61K31/728A61K2800/5922A61P17/06A61K2300/00A61K47/36A61K47/26A61K31/593A61P17/00A61P17/16H04W36/0058H04W74/0833
Inventor ALBARANO, TEO
Owner JOYDERMA AG
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