9 results about "Body membranes" patented technology

The present invention relates to the field of body membrane processing and manufacturing technology, and specifically to a high-precision processing method for a human blood vessel model, which specifically includes the following steps: obtaining original data of medical angiography blood vessels; drawing a parametric surface model of the inner wall of the blood vessel; designing and processing a cavity mold; designing and processing an outer frame mold; processing a perfusion mold; using a lost mold; designing and processing a blood vessel stent; surface treatment of the lost mold; coating of blood vessel silicone; finished product output; and assembly of a hollow silicone blood vessel with a pulsation device. In the technical solution of the present invention, the raw materials are easy to purchase and have low cost; the dissolution process can be unmanned and there is no environmental pollution problem; through the action of a rotary molding machine and a circulating water demoulding machine, the blood vessel wall thickness can be ensured to be uniform, large-volume blood vessel models can be formed in one piece, and the yield rate is high. Mass production can be achieved, and the blood vessel model pulsation data can be adjusted according to the human blood pressure values ​​during surgical robot development or preoperative simulation by medical personnel.

The invention relates to the technical field of medical instruments, in particular to a radiotherapy device with a protection function for tumor treatment. Comprising a lifting table, the lifting table is slidably provided with a first moving table, the first moving table is slidably connected with a second moving table, the second moving table is provided with a first electric sliding rail, an electric sliding block on the second moving table is provided with a first electric rotating shaft, and the first electric rotating shaft is fixedly connected with a second electric sliding rail; an electric sliding block on the base is provided with a second electric rotating shaft, the second electric rotating shaft is fixedly connected with a third electric sliding rail, the electric sliding block on the base is rotationally connected with a fixing frame, the fixing frame is provided with a third electric rotating shaft, the fixing frame is rotationally connected with an extrusion frame, and the third electric rotating shaft is fixedly connected with a supporting frame. A body membrane is clamped through the extrusion frame and the supporting frame, so that the body membrane is stably attached to the skin of a patient, and after the body membrane makes contact with the second moving table, a support of the body membrane is pressed, and it is ensured that the position of the body membrane does not change.

The invention provides an absorbable biological barrier membrane with a retainer and an assembling method thereof, and the absorbable biological barrier membrane with the retainer comprises a membrane body which is provided with a first side edge; the protective ring is located on the first side edge of the film body and penetrates through the film body in the thickness direction, the radial periphery of the protective ring is tightly combined with the film body, the protective ring is provided with a center hole, and a film nail penetrates through the center hole so that the film body can be fixed to the using position. According to the absorbable biological barrier membrane, the first side edge of the membrane body is provided with the protective ring, the protective ring enables the membrane body to be stressed evenly at the position where the membrane nail penetrates, the membrane body is not prone to being torn at the position where the membrane nail penetrates, and the absorbable biological barrier membrane with the protective ring can be stably arranged at the using position; the protective ring can be fixed by using a screw-in type membrane nail, so that the brain is prevented from being vibrated and damaged by knocking force when the knocking type membrane nail is used for fixing; the protective ring can be fixed on the tongue side through a screw-in type membrane nail, so that the problem that an existing knocking type membrane nail cannot be used on the tongue side is solved.

This invention provides a FAP-targeted engineered exosome for treating hypertrophic scars, its preparation method, and its application, belonging to the field of biopharmaceutical manufacturing technology. After co-incubation with an ferroptosis inducer, the FAP-targeting small molecule ligand SUC-Lys(Ac)-PEG3-UAMC1110 is covalently linked to the exosome membrane surface using an EDC / NH-mediated amide bond coupling strategy to obtain engineered exosomes. These engineered exosomes are then used to prepare microneedle patches. The microneedle patches allow the engineered exosomes to accumulate at the scar site and preferentially enter FAP-highly expressed scar fibroblasts, inhibiting their abnormal proliferation, migration, and pro-fibrotic phenotype, reducing collagen deposition, and promoting hypertrophic scar tissue remodeling. This invention combines the advantages of strong targeting, low off-target toxicity, minimally invasive drug delivery, sustained local retention, and stable efficacy, making it suitable for preparing drugs to treat or improve hypertrophic scars, and possessing good clinical translational potential.

The present invention discloses engineered exosomes, said engineered exosomes comprising (a) a KGF polypeptide fused to a first anchor polypeptide, (b) an EGF polypeptide fused to a second anchor polypeptide, and (c) an FGF-2 polypeptide fused to a third anchor polypeptide, wherein (a), (b) and (c) are anchored to the membrane of said exosomes through the first, second, and third anchor polypeptides, respectively, said KGF polypeptide, said EGF polypeptide, and said FGF-2 polypeptide are exposed on the outer surface of said exosome membrane. The present invention further discloses the use of said exosomes in compositions, nucleic acid structures, and skin rejuvenation.

The invention discloses an adjustable protection device for tumor radiotherapy. The adjustable protection device comprises a bed body, an adjusting groove is formed in the middle of the bed body, and the posture adjusting assembly is installed in the adjusting groove; the position adjusting assemblies are mounted on the left and right sides of the bed body; the body film covering assembly is mounted at the moving end of the position adjusting assembly; the barrier protection components are mounted on the front and rear sides of the bed body; through the posture adjusting assembly, when a patient lies on the bed body, the patient is adjusted within the range of the upper part, the middle part and the lower part, so that the relative displacement between the body membrane and the body caused by changes of the weight and the body circumference is reduced, radiotherapy equipment can more accurately project high-dose rays to a tumor target region in the subsequent radiotherapy process, and the radiotherapy efficiency is improved. The damage to healthy body tissues is reduced; through cooperation of the body membrane covering assembly and the position adjusting assembly, the body membrane can rapidly cover the surface of the body of a specified patient, cooperation of multiple medical workers is not needed, and dependence on the operation proficiency of the medical workers is reduced.

The invention relates to the technical field of nano-drugs, in particular to a multifunctional nano-enzyme for treating rheumatoid arthritis and a preparation method of the multifunctional nano-enzyme. The H2S gas released by the Pt (at) S-ZIF-8 multi-antioxidant nano-system constructed in the Pt (at) S-ZIF-8 ExosSyETP nano-system prepared by the invention can enhance the catalytic activity of the nano-enzyme, and the strategy of nano-enzyme synergistic gas treatment is applied to the treatment of rheumatoid arthritis; the exosome membrane derived from immature dendritic cells can play a role in immunoregulation, inhibit excessive activation of an immune system and relieve inflammatory response; the synovial membrane targeting peptide CKSTHDRLC can help the system target a joint synovial membrane inflammation part, and the problem that a traditional drug is poor in targeting performance is solved; the system can relieve inflammatory lesions of rheumatoid arthritis through multi-layer and multi-strategy networked regulation and control, realizes efficient treatment of rheumatoid arthritis, and provides a new strategy for treatment of rheumatoid arthritis.

The application belongs to the technical field of targeted drugs, and particularly relates to 293T exosome for targeted delivery of pirfenidone with FAP on the membrane as well as a preparation method and application thereof. The application uses exosome secreted by 293T cells as a natural nanocarrier, modifies FAP antibody with fibroblast targeting property on the membrane surface of the exosome through copper-free click chemistry, and uses an ultrasonic method to load anti-fibrosis drug PFD into the exosome, so as to construct an engineered exosome system (293T exo antiFAP+PFD ) with functions of targeted recognition and drug delivery. The system is delivered to the lung through a nebulization inhalation mode, can realize accurate enrichment and stable release of PFD in a pulmonary fibrosis lesion, and thus effectively relieves damage to the lung tissue structure and collagen deposition, and significantly improves the anti-fibrosis effect. The technology solves the problems of low drug delivery efficiency, large side effects and poor targeting in traditional treatment, and provides a safe, efficient and accurate treatment strategy for pulmonary fibrosis.

The present application relates to a macrophage-targeting functional extracellular vesicle and a preparation method and application thereof, and relates to the technical field of biological medicine. The preparation method comprises the following steps: preparing COFs particles loaded with ATP citrate lyase inhibitors by one-pot method through covalent organic framework material and ATP citrate lyase inhibitors; and preparing the macrophage-targeting functional extracellular vesicle by ultrasonic thin film extrusion method through the COFs particles loaded with ATP citrate lyase inhibitors and apoptotic body membranes. The macrophage-targeting functional extracellular vesicle provided by the present application can target macrophages and accurately release drugs to regulate the polarization state of macrophages, thereby providing an effective means for constructing anti-inflammatory treatment products. Meanwhile, the constructed functional extracellular vesicle can reprogram the polarization state of macrophages, regulate the local immune microenvironment, promote the formation of new blood vessels of diabetic skin wounds, and promote wound healing.