5 results about "Body membranes" patented technology

The invention relates to the technical field of medical instruments, in particular to a radiotherapy device with a protection function for tumor treatment. Comprising a lifting table, the lifting table is slidably provided with a first moving table, the first moving table is slidably connected with a second moving table, the second moving table is provided with a first electric sliding rail, an electric sliding block on the second moving table is provided with a first electric rotating shaft, and the first electric rotating shaft is fixedly connected with a second electric sliding rail; an electric sliding block on the base is provided with a second electric rotating shaft, the second electric rotating shaft is fixedly connected with a third electric sliding rail, the electric sliding block on the base is rotationally connected with a fixing frame, the fixing frame is provided with a third electric rotating shaft, the fixing frame is rotationally connected with an extrusion frame, and the third electric rotating shaft is fixedly connected with a supporting frame. A body membrane is clamped through the extrusion frame and the supporting frame, so that the body membrane is stably attached to the skin of a patient, and after the body membrane makes contact with the second moving table, a support of the body membrane is pressed, and it is ensured that the position of the body membrane does not change.

This invention provides a FAP-targeted engineered exosome for treating hypertrophic scars, its preparation method, and its application, belonging to the field of biopharmaceutical manufacturing technology. After co-incubation with an ferroptosis inducer, the FAP-targeting small molecule ligand SUC-Lys(Ac)-PEG3-UAMC1110 is covalently linked to the exosome membrane surface using an EDC / NH-mediated amide bond coupling strategy to obtain engineered exosomes. These engineered exosomes are then used to prepare microneedle patches. The microneedle patches allow the engineered exosomes to accumulate at the scar site and preferentially enter FAP-highly expressed scar fibroblasts, inhibiting their abnormal proliferation, migration, and pro-fibrotic phenotype, reducing collagen deposition, and promoting hypertrophic scar tissue remodeling. This invention combines the advantages of strong targeting, low off-target toxicity, minimally invasive drug delivery, sustained local retention, and stable efficacy, making it suitable for preparing drugs to treat or improve hypertrophic scars, and possessing good clinical translational potential.

The invention discloses an adjustable protection device for tumor radiotherapy. The adjustable protection device comprises a bed body, an adjusting groove is formed in the middle of the bed body, and the posture adjusting assembly is installed in the adjusting groove; the position adjusting assemblies are mounted on the left and right sides of the bed body; the body film covering assembly is mounted at the moving end of the position adjusting assembly; the barrier protection components are mounted on the front and rear sides of the bed body; through the posture adjusting assembly, when a patient lies on the bed body, the patient is adjusted within the range of the upper part, the middle part and the lower part, so that the relative displacement between the body membrane and the body caused by changes of the weight and the body circumference is reduced, radiotherapy equipment can more accurately project high-dose rays to a tumor target region in the subsequent radiotherapy process, and the radiotherapy efficiency is improved. The damage to healthy body tissues is reduced; through cooperation of the body membrane covering assembly and the position adjusting assembly, the body membrane can rapidly cover the surface of the body of a specified patient, cooperation of multiple medical workers is not needed, and dependence on the operation proficiency of the medical workers is reduced.

The application belongs to the technical field of targeted drugs, and particularly relates to 293T exosome for targeted delivery of pirfenidone with FAP on the membrane as well as a preparation method and application thereof. The application uses exosome secreted by 293T cells as a natural nanocarrier, modifies FAP antibody with fibroblast targeting property on the membrane surface of the exosome through copper-free click chemistry, and uses an ultrasonic method to load anti-fibrosis drug PFD into the exosome, so as to construct an engineered exosome system (293T exo antiFAP+PFD ) with functions of targeted recognition and drug delivery. The system is delivered to the lung through a nebulization inhalation mode, can realize accurate enrichment and stable release of PFD in a pulmonary fibrosis lesion, and thus effectively relieves damage to the lung tissue structure and collagen deposition, and significantly improves the anti-fibrosis effect. The technology solves the problems of low drug delivery efficiency, large side effects and poor targeting in traditional treatment, and provides a safe, efficient and accurate treatment strategy for pulmonary fibrosis.

The present application relates to a macrophage-targeting functional extracellular vesicle and a preparation method and application thereof, and relates to the technical field of biological medicine. The preparation method comprises the following steps: preparing COFs particles loaded with ATP citrate lyase inhibitors by one-pot method through covalent organic framework material and ATP citrate lyase inhibitors; and preparing the macrophage-targeting functional extracellular vesicle by ultrasonic thin film extrusion method through the COFs particles loaded with ATP citrate lyase inhibitors and apoptotic body membranes. The macrophage-targeting functional extracellular vesicle provided by the present application can target macrophages and accurately release drugs to regulate the polarization state of macrophages, thereby providing an effective means for constructing anti-inflammatory treatment products. Meanwhile, the constructed functional extracellular vesicle can reprogram the polarization state of macrophages, regulate the local immune microenvironment, promote the formation of new blood vessels of diabetic skin wounds, and promote wound healing.