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Membranes are thin layers of epithelial tissue usually bound to an underlying layer of connective tissue. Membranes cover, protect, or separate other structures or tissues in the body. The four types of membranes are: 1) cutaneous membranes; 2) serous membranes; 3) mucous membranes; and 4) synovial membranes.
Fap-targeted engineered exosomes for treating hypertrophic scars and preparation method and application thereof
PendingCN122163820APharmaceutical delivery mechanismPharmaceutical non-active ingredientsTissue remodelingFibrosis
This invention provides a FAP-targeted engineered exosome for treating hypertrophic scars, its preparation method, and its application, belonging to the field of biopharmaceutical manufacturing technology. After co-incubation with an ferroptosis inducer, the FAP-targeting small molecule ligand SUC-Lys(Ac)-PEG3-UAMC1110 is covalently linked to the exosome membrane surface using an EDC / NH-mediated amide bond coupling strategy to obtain engineered exosomes. These engineered exosomes are then used to prepare microneedle patches. The microneedle patches allow the engineered exosomes to accumulate at the scar site and preferentially enter FAP-highly expressed scar fibroblasts, inhibiting their abnormal proliferation, migration, and pro-fibrotic phenotype, reducing collagen deposition, and promoting hypertrophic scar tissue remodeling. This invention combines the advantages of strong targeting, low off-target toxicity, minimally invasive drug delivery, sustained local retention, and stable efficacy, making it suitable for preparing drugs to treat or improve hypertrophic scars, and possessing good clinical translational potential.
Owner:GENERAL HOSPITAL OF PLA