The process relates to a process for printing a QS quality safety sign on gold card paper, which comprises the following steps: 1, carrying out computer color separation on a QS sign pattern to be printed, and separately making an electronic file with all edges longer than the size of a white pattern; 2, making 3 films by using the file made in the step 1; 3, carrying out plate burning by using the films in the step 1 to make 3 corresponding printing plates; 4, installing the printing plates obtained in the step 3 on an offset press; 5, pouring a shell-lac alcoholic solution and water in a first machine set; pouring white ink and a fountain solution in a second machine set; and pouring spot blue ink and the fountain solution in a third machine set; 7, installing ultraviolet light tubes between the first machine set and the second machine set, between the second machine set and the third machine set and behind the third machine set; 8, printing shell-lac by the first machine set, printing the white ink by the second machine set, and printing the spot blue ink by the third machine set, and then obtaining a QS sign printing product. The process has the advantages of convenient printing, less process faults, flat and smooth ink layers and good handfeel.