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Cepharanthine oral disintegration tablet and its preparing method

A technology of orally disintegrating tablets and stephadin, which is applied in the field of stephadin orally disintegrating tablets, can solve the problems of low bioavailability, inconvenient taking, and affecting the effect of treatment, etc.

Inactive Publication Date: 2008-05-14
COSCI MED TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] 5. Animal toxicity
[0015] Due to preparation technology and other reasons, most oral preparations have problems such as long dissolution time, low dissolution rate, poor absorption and low bioavailability after taking, which affects the efficacy of the drug and directly affects the effect of treatment.
In addition, traditional oral preparations require a large amount of water to be taken down, which makes it inconvenient for weak cancer patients to take them. In addition, the adverse reaction of cancer patients during radiotherapy and chemotherapy is vomiting. The drug compliance of ordinary preparations is poor. Good for taking

Method used

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  • Cepharanthine oral disintegration tablet and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] 1. Prescription

[0039] 1. Raw material - 20.0g of stephadin;

[0040] 2. Adhesive - polyvinylpyrrolidone K-30 3.0g;

[0041] 3. Filling agent - mannitol 80.0g;

[0042] Microcrystalline Cellulose 10.0g

[0043] Starch 10.0g

[0044] 4. Flavoring agent - aspartame 1.0g;

[0045] Ginseng essence 1.0g;

[0046] 5. Disintegrant—cross-linked polyvinylpyrrolidone 12.0g;

[0047] Low-substituted hydroxypropyl cellulose 16.0g;

[0048] 6. Glidant—micronized silica gel 1.0g;

[0049] 7. Lubricant—magnesium stearate 1.0g.

[0050]

[0051] A total of 1000 pieces were made

[0052] 2. Preparation method

[0053] 1) Mix the raw material of pachyphyllin with starch, make a soft material with a 70% aqueous solution containing 20% ​​polyvinylpyrrolidone K-30, pass through a 30-mesh sieve to granulate, dry, and granulate with a 30-mesh sieve for later use;

[0054] 2) Mix mannitol, microcrystalline cell...

Embodiment 2

[0056] Example 2 The taste-masking method of drug coating on pellets

[0057] 1. Prescription

[0058] 1. Raw material - stephadin 200.0g;

[0059] 2. Blank pellet core (grain diameter: 200 microns) 160.0g;

[0060] 4. Adhesive - PVP k30 Ethanol solution with PVP k30 20.0g;

[0061] 5. Coating material—— E100 18.0g;

[0062] NE30D (dry) 4.0g;

[0063] 6. Filling agent - mannitol 600.0g;

[0064] Microcrystalline cellulose 100.0g;

[0065] 7. Flavoring agent - aspartame 5.0g;

[0066] Orange essence 5.0g;

[0067] 8. Disintegrant—cross-linked polyvinylpyrrolidone 100.0g;

[0068] Low-substituted hydroxypropyl cellulose 75.0g;

[0069] 9. Glidant - micronized silica gel 10 0g;

[0070] 10. Lubricant—sodium stearyl fumarate 10.0g.

[0071]

[0072] A total of 10,000 pieces were made

[0073] 2. Preparation method

[0074] 1. Make PVP-k30 into 10% ethanol solution, add stepherin to dissolve and set aside...

Embodiment 3

[0079] Example 3 Stirring granulation mechanism Pellet coating taste masking method

[0080] 1. Prescription

[0081] 1. Raw material - stephadin 200.0g;

[0082] 2. Accessory material - starch 200.0g

[0083] Dextrin 60.0g

[0084] Sucrose powder 40.0g

[0085] Magnesium Stearate 2.0g

[0086] 3. Adhesive - 70% ethanol solution appropriate amount

[0087] 4. Coating material—— E100 60.0g;

[0088] NE30D (dry) 5.0g;

[0089] 5. Filling agent - mannitol 400.0g;

[0090] Microcrystalline cellulose 120.0g;

[0091] 6. Flavoring agent—aspartame 5.0g;

[0092] Orange essence 5.0g;

[0093] 7. Disintegrant—cross-linked polyvinylpyrrolidone 120.0g;

[0094] Low-substituted hydroxypropyl cellulose 80.0g;

[0095] 9. Lubricant—magnesium stearate 10.0g.

[0096]

[0097] A total of 10,000 pieces were made

[0098] 2. Preparation method

[0099] 1. Mix stephatrin, starch, dextrin, ...

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Abstract

The present invention relates to a kind of orally disintegrating cepharanthine tablet, which has the functions of promoting reticuloendothelial system, resisting allergic reaction, etc. and is used in preventing and treating leucopenia caused by radiotherapy and chemotherapy, and its preparation process. The orally disintegrating cepharanthine tablet is prepared with cepharanthine as main material and stuffing, disintegrating agent, corrective, flow assistant, lubricant, adhesive or coating material, effervescent agent and other supplementary material, and through tablet pressing in a tablet press. The orally disintegrating cepharanthine tablet has high friability, fast disintegrating, good taste, low production cost and other advantages.

Description

technical field [0001] The invention relates to an orally disintegrating tablet of stepherin, which has the functions of promoting reticuloendothelial system and antiallergic reaction, and is used for the prevention and treatment of leukopenia caused by radiation or chemotherapy and its preparation process. Background technique [0002] Cepharanthine is a kind of bisbenzylisoquinoline alkaloid, which is extracted from the medicinal plants of the genus Stephaniaceae. Cepharanthine has anti-inflammatory, antibacterial, and immune-regulating functions, etc. effect. In recent years, many scholars believe that it also has the function of stimulating the reticuloendothelial system, activating hematopoietic tissue, and promoting the proliferation of bone marrow tissue. It has been used clinically to treat leukopenia and has received certain results. A low-toxic and effective white blood cell-increasing drug. [0003] At present, the chemical, pharmacological and clinical research...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/4741A61P37/08A61P35/00A61P43/00
Inventor 蒋海松王锦刚
Owner COSCI MED TECH CO LTD
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