Animal stomach extract and use thereof as medicament for treating gastropathy

An extract and animal technology, applied in drug combinations, medical preparations containing active ingredients, pharmaceutical formulations, etc., can solve the difficult problems of the attending doctor, and achieve the effects of avoiding deterioration of cancer, preventing cancer and aging, and promoting the regeneration of mucosal tissue.

Inactive Publication Date: 2009-09-23
何执中
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are many patients with coexistence of chronic gastritis and peptic ulcer clinically, which makes it difficult for the attending doctor.

Method used

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  • Animal stomach extract and use thereof as medicament for treating gastropathy
  • Animal stomach extract and use thereof as medicament for treating gastropathy
  • Animal stomach extract and use thereof as medicament for treating gastropathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 "Weiwei" prepared by adding pig pancreas to the gastric mucosa of pigs

[0026] Take 1 kg of pig gastric mucosa and 2 kg of pig pancreas, and grind them separately as raw materials. Add 2 liters of water to the container, and add raw materials twice during stirring to make a homogenate. Adjust the pH to 4 with salt and hydrochloric acid, and extract with stirring at 35°C for 5 hours. Then use caustic soda to adjust the feed solution to pH 6-7, and cool down to about 10°C with a cold water bath while stirring. The residue was removed by filter cloth filtration, and the resulting 3 liters of filtrate was concentrated to 1.8 liters at 30° C. with a membrane concentrator. Pack it into a tray and freeze-dry it with a freeze dryer for 22 hours. The resulting solid is pulverized and sieved to obtain 108 grams of "Wei Wei" powder (sample A).

example 2

[0027] Example 2 prepares "Wei Wei" with pig stomach as raw material

[0028] Take 1 kg of piglet stomach, mince it, add 0.6 liters of water, a little salt and acetic acid to the reactor, adjust the slurry to pH 3.5, stir and extract at 38°C for 4 hours, then adjust the slurry to pH 6-7 with caustic soda . Continue to stir and cool down to 12°C with an ice bath or water bath. Centrifuge to obtain 1.1 liters of filtrate; add 4 liters of edible alcohol to the filtrate under stirring, let it stand, and centrifuge to collect the precipitate after layering. After dehydration and pressure drying, move it into a vacuum drying oven to dry for 10 hours to obtain a dry solid, which is then pulverized and sieved to obtain 28 grams of "Weiwei" off-white powder (sample B).

[0029] The above "Weiwei" sample A and sample B were qualitatively detected by ultraviolet light scanning, and the obtained spectra are shown in the attached figure. It can be seen in the figure that the maximum ult...

Embodiment 3

[0032] Example 3: Test of the therapeutic effect of "Weiwei" on reserpine-type gastric ulcer in mice

[0033] 60 mice were divided into the following four groups, 10 in each group from ① to ③, 30 in total in group ④, and divided into three groups, 10 in each group. Among them, each mouse in each group from ② to ④ was gavaged with reserpine (according to 10 mg / kg dose) to make a model of gastric ulcer caused by gastric injury.

[0034] ①Blank group (10 mice): Gave the same amount of distilled water orally.

[0035] ② Control group (10 mice): Gave the same amount of distilled water orally.

[0036] ③ Ranitidine group (10 mice): 20 mg / kg ranitidine was given orally.

[0037] ④ "Wei Wei" group (30 mice): Each group of 10 mice was given 0.3, 0.1, 0.03 g / kg different doses of "Wei Wei" sample A by gavage.

[0038] One hour after the administration, the mice were sacrificed, and the stomach was taken out, and 2 mL of 1% formaldehyde was injected for fixation.

[0039] The gastric...

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PUM

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Abstract

The invention relates to a stomach extractive of mammal, which uses the stomach or mucosa of single-stomach mammal as material, to be broken and added with pure water or physiological saline, added with acid material and conservative to adjust the Ph value to 2-5, to be mixed at 20-50Deg. C for 2-6h, and added with edible alkali material to adjust the pH value to 6-7, to be mixed and cooled to 8-12Deg. C, to be filtered to obtain the filter liquor; then depressurizes and concentrates the filter liquor, puts the concentrates material into refrigerator drier, to obtain solid after 20-36h; breaks and screens into powder. The inventive extractive contains variable biological active components, with better biocompatibility with stomach of human body, to adjust the stomach function and treat stomach diseases.

Description

technical field [0001] The present invention relates to a stomach extract of a mammal, especially a stomach extract of a monogastric mammal (that is, excluding mammals with multiple stomachs), and the use of the extract as a medicine for treating stomach diseases. Background technique [0002] About 200 million people in my country suffer from chronic stomach diseases, and there are no less than dozens of Chinese and Western stomach medicines commonly used at present. Many "old stomach problems" have taken countless medicines for decades, but they still keep getting sick. The reason for this embarrassing situation of "peaceful coexistence" of "stomach disease" and "stomach medicine" long-term dependence is that many stomach medicines are "not right for the disease" and "cure the symptoms but not the root cause". Moreover, the recurrence rate after treatment is high, and the resurgence is very fast. Clinically, there are even case reports of relapse after three days of drug...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/38A61P1/04
Inventor 何执中何晓瑾唐宁
Owner 何执中
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