Aminoglucose calcium tablet and its prepn process

Abstract

The present invention is dispersed aminoglucose calcium tablet for preventing and treating osteoarthritis and osteoporosis and its preparation process. The dispersed aminoglucose calcium tablet has prepared with aminoglucose and calcium citrate as effective components, and excipient, disintegrant, lubricant, adhesive and wetting agent as supplementary material. Its preparation process includes crushing the materials, sieving, mixing, pelletizing and tabletting. Compared with common tablet, the dispersed aminoglucose calcium tablet has high dispersivity, high leaching speed, fast acting and other advantages.

Description

technical field [0001] The invention belongs to the field of glucosamine pharmaceutical application, and in particular relates to a glucosamine calcium tablet preparation for treating and preventing osteoarthritis and osteoporosis and a preparation method thereof. Background technique [0002] Osteoarthritis (OA) is a common chronic arthritis, and people have been looking for and exploring drugs to control the development of OA for many years. In 1969, Germany first clinically tested glucosaminesulfate (GS) for the treatment of OA. After several short-term and long-term random double-blind observations on the results of GS treatment of knee OA, it was shown that the product can not only reduce inflammation and relieve pain, but also delay the development of knee OA. In vitro experiments have confirmed that it has a good effect on cartilage metabolism, so GS is considered to be the first drug to change the condition of OA (also a chondroprotective agent), and is currently rec...

AI Technical Summary

Problems solved by technology

[0007] However, at present, the dosage forms of the combined application of glucosamine and calcium drugs are mainly capsule dosage forms and ordinary tablets. According to reports, Chinese patent application 200610029813.9 discloses a glucosamine effervescent preparation, which provides a way for patients with dysphagia to be dispersed in water and then taken orally. It has the following advantages: it contains organic acids and bicarbonate or carbonate, When in contact with water, a large amount of carbon dioxide can be released and become effervescent; because the effervescent tablet has a special disintegrant—the effervescent disintegrating agent, the oral effervescent tablet can be disintegrated quickly in cold water, which is good for absorption, and it is better than other dosage forms to take with you It is convenient, and most effervescent tablets add flavoring agents to taste better, which is easy for patients to accept

[0008] But its disadvantages are: 1. Drugs that interact with effervescent acid-base solutions have prescription incompatibility; 2. Effervescent agents and water-soluble auxiliary materials are required; 3. The production conditions are relatively strict, and room temperature (<20°C) needs to be controlled and relative humidity (<25%), the preparation process is more complicated, 4, the method of taking can only be taken orally after dispersing in water, can not be swallowed, and can not provide more than two kinds of combination options for patients

There are no relevant reports on glucosamine and calcium citrate tablet preparations in the prior art