Method for extracting high-purity solanesol from potato leaf, tobacco leaf and/or tobacco stem

Abstract

A method of extracting high-purified solanesol from potato leaves, tobacco leaves and / or tobacco stems is that the solanesol is extracted from the raw materials by extracting solvent, solanesol extract is obtained after solid-liquid separation; the solanesol extract is processed for the phase-transfer catalytic saponification reaction inside an organic-solvent-buck-phase-transfer catalyst system; the solanesol extract after saponification is completely dissolved in mixed alcohol-acetone solvent under 50 DEG C to 75 DEG C for stationary placing, cooling and filtering; filtrate is steamed to be dry to obtain the solanesol extract after wax removal, and the solanesol extract is dissolved in methanol or acetonitrile in reflux to be frozen and crystallized for obtaining white solid which is dried to obtain the solanesol. The present invention has the advantages of gentle reaction condition, simple technology, short production period, large batch, the high yield and purity of the solanesol and being convenient for industrialization.

Description

technical field [0001] The invention relates to a method for extracting highly purified solanesol from potato leaves, tobacco leaves and / or tobacco rods. Background technique [0002] Solanesol Solanesol is a polyprenyl alcohol with the molecular formula C 45 h 74 The simplified structure of O is H[CH 2 C(CH 3 )CHCH 2 ] 9 OH, relative molecular weight: 631, pure product is white waxy solid, melting point 41°C. Weak polarity, easily soluble in organic solvents. Solanesol is a long-chain fatty alcohol with multiple non-conjugated double bonds in its structure and has a very strong ability to absorb free radicals. It mainly exists in tobacco leaves, tobacco stems, and potato leaves. Solanesol is an important pharmaceutical intermediate, which can be used to synthesize vitamin K 2 and coenzyme Q 10 It can also be used as a raw material for the synthesis of some antiallergic drugs, antiulcer drugs, hypolipidemic drugs or anticancer drugs, and it is also a substance with ...

AI Technical Summary

Problems solved by technology

The content of solanesol in the bound state accounts for 40-60% of the total amount of solanesol, and the common method to convert the solanesol in the bound state into free solanesol is to saponify it with alkali in its alcohol solution; Alcohol contains multiple non-conjugated double bonds, its chemical properties are unstable, and it is easy to undergo oxidation reaction under strong alkali conditions, thereby reducing the yield of solanesol. For this, the commonly used method is to add weak base and inert gas protection Or add anti-oxidant, above-mentioned method has solved the oxidation problem during saponification to a certain extent, but also has the following problems: weak base saponification, reaction speed is too high, and cycle is long, needs relatively high temperature; Inert gas protection makes reaction basically be in The sealed system is easy to cause pressure accumulation, strict equipment requirements, and high operating costs; antioxidants must be oxidized before solanesol, consume oxygen in the reaction system, and prevent solanesol from being oxidized, which in turn gives solanesol and The separation of antioxidants has brought difficulties, and a suitable saponification process is the bottleneck for improving the yield of solanesol and reducing costs

The above-mentioned methods generally lack effective wax removal procedures, and a certain amount of wax will still remain in the product obtained by crystallization and recrystallization, and, due to the oxidation side reaction of solanesol in the saponification process, the overall yield is partial. Low