Oral capsule agent for preventing and treating AIDS and method for preparing the same

A technology of capsules and AIDS, applied in the field of biomedicine, can solve the problems of not being able to block the early infection process of HIV, the difficulty of vaccine development, and the rapid mutation of HIV, and achieve considerable economic benefits, stable and controllable quality, and the effect of reducing blood lipids

Inactive Publication Date: 2008-07-16
BEIJING UNION GENIUS PHARMA TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These medicines and methods have the following disadvantages: (1) induce drug-resistant HIV variants; (2) have short-term and long-term toxic and side effects; (3) cannot block the early infection process of HIV
Due to the rapid mutation of HIV, the strains in different regions may also be different, making the development of vaccines very difficult

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Implementation Example 1 Preparation of high-ester type catechin microcapsules by single coacervation method

[0023] formula:

[0024] High Ester Catechin 10g

[0025] Gelatin 80g

[0026] Preparation process: Add high-ester catechin into 2400ml of 60°C non-salt water, carefully adjust the pH to 7.2-7.8 with 0.01% NaOH, add gelatin at 37°C, keep warm, stir to dissolve, add 10% acetic acid solution dropwise To pH 3.5-3.8, the reactor was placed in a water bath at 50° C. and kept stirring for 45 minutes. Add sodium sulfate solution (diluent) dropwise, observe under a microscope until it forms capsules, immediately pour it into the diluent that is being stirred, after gelling and settling, pour off the supernatant, and wash with diluent 2 to 3 times , to remove uncoagulated capsule material. Finally, suspend the microcapsules in an appropriate amount of diluent, add 2-3ml of 37% formaldehyde solution, stir, add dropwise sodium hydroxide to adjust the pH to 8-9, leave ...

Embodiment 2

[0027] Implementation Example 2 Solvent-non-solvent method prepares high-ester type catechin microcapsules

[0028] formula:

[0029] High Ester Catechin 10g

[0030] Butyl cellulose acetate 240g

[0031] Butanone 6000g

[0032] Preparation process: Dissolve butyl cellulose acetate in 6000ml of methyl ethyl ketone, and pay attention to make it completely dissolved, and set aside. Add high-ester catechins therein, place the reactor containing the reaction solution in a water bath at 55° C., heat and stir for 45 minutes. Slowly add the non-solvent isopropyl ether under the condition of stirring, and wrap the suspended core material into microcapsules when the condensed phase separation occurs. Slowly cool down to room temperature, separate the microcapsules by centrifugation, wash with isopropyl ether, and dry in vacuum to obtain the desired microcapsules.

Embodiment 3

[0033] Implementation example 3 Preparation of high-ester type catechin microcapsules by double emulsion encapsulation

[0034] formula:

[0035] High Ester Catechin 10g

[0036] Ethylcellulose 98g

[0037] Gum Arabic 38g

[0038] Preparation process: first dissolve ethyl cellulose in 2500ml of ethyl acetate, and pay attention to make it completely dissolved, then add high-ester type catechin into it to obtain an organic phase (containing an appropriate amount of di-n-butyl phthalate) as a plasticizer). 2500ml of 5% gum arabic solution was added dropwise and dispersed in the above organic phase to form a W / O type emulsion. And further form double milk. Filter and dry at low temperature to obtain microcapsules with a diameter of less than 50 μm, most of which are about 15 μm. The inner and outer layers of the microcapsule are gum arabic membranes, and the middle layer is ethyl cellulose membrane.

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PUM

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Abstract

The invention relates to a capsule for preventing and treating AIDS and a preparation technique thereof, pertaining to biomedical field, in particular to a capsule with high-esterified catechin as the main active ingredient thereof and a preparation technique of a micro-capsule of the high-esterified catechin as well. Microencapsulation enhances the stability of the high-esterified catechin and covers the unpleasant odor and taste. AIDS is one of the five main causations of death all over the world. The product of the invention is applied in the treatment of AIDS, performs a rather strong lethality on the AIDS, and can be substituted for the expensive and high-toxic imported drugs, which is suitable for national conditions of China, thereby having considerable economic benefits and promising market prospect.

Description

technical field [0001] The invention relates to the field of biomedicine, and relates to a capsule for preventing and treating AIDS and its preparation technology, in particular to a capsule with high-ester catechin as the main active ingredient. The invention also relates to a preparation technology of high-ester type catechin microcapsules. Background technique [0002] Since the 1980s, Acquired Immunodeficiency Syndrome (also known as AIDS, AIDS) has become a major disease that threatens human health, and the number of cases is increasing year by year. So a famous western medical expert called AIDS "the plague of the century". On December 1, 2003, the "Joint Assessment Report on AIDS Prevention and Control in China" jointly issued by the Ministry of Health of China and the United Nations AIDS China Task Force showed that there are currently about 840,000 HIV-infected people in China, and about 80,000 AIDS patients, distributed in all provinces of the country , autonomou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K9/50A61K9/48A61K47/32A61K47/34A61K47/36A61K47/38A61K47/40A61K47/42A61P31/18A61K47/10
Inventor 李万芳张维英王选圣王爱平姜生魏金峰靳洪涛
Owner BEIJING UNION GENIUS PHARMA TECH
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