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Eye drop capable of significantly increasing medicament effect

A technology of eye drops and substances, applied in the field of levofloxacin eye drops, can solve the problems of enhancing levofloxacin, unqualified color properties, etc., achieve remarkable stability and therapeutic advantages, and enhance the effect of antibacterial effect

Active Publication Date: 2008-10-08
江苏广承药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The object of the present invention is to provide a kind of levofloxacin eye drop, especially the levofloxacin eye drop containing sorbic acid, which overcomes the need for special aseptic subpackaging line in the production of existing levofloxacin eye drop, and overcomes the problem of quinolone eye drop. The problem of poor stability such as unqualified color properties and decomposition of the main drug components often occurs in the solution, and the inhibitory and killing effect of levofloxacin eye drops on mold, yeast and other harmful flora is enhanced, and more importantly, the effect of sorbic acid The addition significantly enhances the antibacterial effect of levofloxacin, reduces production costs, overcomes the limitations of the existing processing technology, and opens up a new situation for the field of eye drop preparations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Levofloxacin 0.488g

[0044] Sodium chloride 0.9g

[0045] Sorbic acid 0.1g

[0046] Hydrochloric acid amount

[0047] Appropriate amount of sodium hydroxide

[0048]

[0049] Add water for injection to 100ml

[0050] Preparation

[0051] Disperse levofloxacin and add it to an appropriate amount of water for injection, drop hydrochloric acid solution under stirring to dissolve it completely, add sorbic acid and sodium chloride in turn, adjust the pH value with sodium hydroxide, add water for injection to the required amount, add activated carbon to stir, and filter coarsely Remove charcoal, then fine filter through a microporous membrane until the clarity of the solution passes the inspection, the pH value is controlled at 6.2 to 6.8, and the intermediate is filled after passing the inspection.

Embodiment 2

[0053] Levofloxacin 0.488g

[0054] Sodium chloride 0.9g

[0055] Sorbic acid 0.1g

[0056] Sodium Hyaluronate 0.05g

[0057] Citric acid amount

[0058] Sodium citrate amount

[0059]

[0060] Add water for injection to 100ml

[0061] Preparation

[0062] Add levofloxacin and citric acid into an appropriate amount of water for injection, stir to dissolve them completely, add sorbic acid, sodium chloride, and sodium hyaluronate in sequence, adjust the pH value with sodium citrate, add water for injection to the required amount, add activated carbon and stir, and roughly Filter out the charcoal, and then fine filter through a microporous membrane until the clarity of the solution passes the inspection, and the pH value is controlled at 6.2 to 6.8. After passing the inspection of the intermediate, it is filled.

Embodiment 3

[0064] Levofloxacin 0.488g

[0065] Sodium chloride 0.9g

[0066] Sorbic acid 0.1g

[0067] Sodium Hyaluronate 0.05g

[0068] Povidone 0.1g

[0069] Appropriate amount of boric acid

[0070] Appropriate amount of borax

[0071]

[0072] Add water for injection to 100ml

[0073] Preparation

[0074] Add levofloxacin and boric acid into an appropriate amount of water for injection, stir to dissolve them completely, add sorbic acid, sodium chloride, sodium hyaluronate, povidone in turn, adjust the pH value with borax, add water for injection to the required amount, add activated carbon and stir, Coarse filtration to remove carbon, and fine filtration through a microporous membrane until the solution clarity inspection is qualified, and the pH value is controlled at 6.2 to 6.8. After the intermediate inspection is qualified, it is filled.

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PUM

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Abstract

The invention provides a levofloxacin eyedrops and a preparation method thereof. The eyedrops contains levofloxacin, sodium chloride, sorbic acid and water; refrigerant and thickening agent also can be added; and PH value is regulated. The sorbic acid is taken as antibacterial synergist, stabilizing agent of formulation, comforting agent of a product and bacterial inhibitor to be capable of remarkably strengthening bacteriostatic effect of the levofloxacin, lengthening residence time of drug in eye region, stabilizing active component, keeping drug effect, reducing production cost and being suitable for various men to use, thereby providing a simpler and more convenient dosage form composition for the levofloxacin eyedrops.

Description

technical field [0001] The invention provides a levofloxacin eye drop, especially the levofloxacin eye drop containing sorbic acid as an antibacterial agent and a synergist. Background technique [0002] The eyeball is an exposed organ, which is very vulnerable to bacterial invasion and infection. The cornea, lens, and vitreous body are transparent tissues without blood vessels, and their immunity is low, which provides a good environment for the growth and reproduction of bacteria. Levofloxacin is the optically active part of the racemate ofloxacin (L-body), and has about 2 times the antibacterial activity of ofloxacin. Eye drops with levofloxacin as the main active ingredient can treat various common infectious diseases in the eye, and are widely used clinically to treat blepharitis, hordeolum, dacryocystitis, conjunctivitis, meibomian gland inflammation, Keratitis, infectious diseases after eye surgery. Levofloxacin eye drops has definite curative effect and low inciden...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/5383A61K47/12A61P27/02
Inventor 程浩文韩立宾文艳秋
Owner 江苏广承药业有限公司
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