Preparation method for anti-inflammation adhesion-proof hemostatic sponge

Abstract

The present invention discloses a preparation method of an antiphlogistic and antisticking stanching sponge. The preparation method includes the following steps: through the cross linking of polyvinyl alcohol, chitosan gel microspheres are fixed on the inner wall of a sponge, the sponge is then soaked in antiphlogistic solution and antisticking solution, and finally, the PVA / drug-loaded chitosan antiphlogistic and antisticking stanching sponge is prepared. The antiphlogistic and antisticking stanching sponge prepared by the method can be trimmed according to the size of an operative cavity in order to be placed into the corresponding part, the pressure on the circumference is uniform, blood can be thoroughly stanched, and the injury on the mucous membrane of the operative cavity is little. The antiphlogistic and antisticking stanching sponge prepared by the method, which has good antiphlogistic, stanching and antisticking functions, biocompatibility, and mechanical and anti-oedema properties, can promote the injured tissues to have strong recovering capability, prevent rebleeding and avoid the inevitable potential virus hazard caused by glutin and animal collagen proteins, so the use safety is greatly improved, and moreover, the antiphlogistic and antisticking stanching sponge can alleviate the pain and discomfort suffered by patients. The antiphlogistic and antisticking stanching sponge is expected to substitute the import products and have remarkable social and economic benefits.

Description

technical field [0001] The invention belongs to the field of medical biological materials, and in particular relates to a preparation method of an anti-inflammatory, anti-adhesion and hemostatic sponge. Background technique [0002] Worldwide, trauma is the leading cause of death among people aged 5 to 44, accounting for 10% of all deaths. Because trauma patients are mainly young people, it causes loss of labor force, death and disability, and imposes a huge burden on society. Although the level of trauma treatment is improving, uncontrolled hemorrhage accounts for 30% to 40% of trauma-related deaths. Early treatment of uncontrolled hemorrhage may be the main method to reduce mortality. Therefore, hemostasis has increasingly become a research hotspot in the medical field. [0003] Conventional hemostasis methods include artificial extrusion, cauterization and wound suturing, but these methods sometimes cannot effectively stop bleeding and prolong the operation time. In ad...

AI Technical Summary

Problems solved by technology

[0003] Conventional hemostasis methods include manual extrusion, cauterization and wound suture, but these methods sometimes cannot effectively stop bleeding and prolong the operation time

In addition, incomplete hemostasis often requires secondary surgery

For many years, in the hemorrhage treatment of skin wounds and soft tissue organ injuries such as spleen and kidney, most of them use naturally derived degradable hemostatic materials, mainly including gelatin sponge, oxidized cellulose, microfiber collagen powder, fibrin glue, collagen sponge, etc. And they each have certain deficiencies: gelatin and collagen have poor tissue adhesion, and the hemostatic function of both depends on sufficient platelets and coagulation factors, so the application is limited; fibrin glue comes from blood, which may cause Lead to viral infection; traditional medicinal cotton gauze to treat skin wounds not only has a long healing period and obvious wound scars, but also the patient is quite painful during the dressing change process

[0007] Patent CN1320931 also provides a polyvinyl alcohol hydrogel dressing containing medicine and chitosan and its preparation method. The invention patent adopts radiation crosslinking to prepare the polyvinyl alcohol hydrogel dressing containing medicine and chitosan, mainly It is used for wet treatment of various skin wounds, but the preparation method is more complicated