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Hydrogen phosphate/tricalcium silicate composite self-curing material with biological activity, preparation and uses thereof

A technology of tricalcium silicate and calcium hydrogen phosphate, used in pharmaceutical formulations, dental preparations, compression mold cups, etc., can solve the problem of not meeting the mechanical requirements of dental tissue repair materials, poor bone-like apatite deposition ability, and low bonding strength. and other problems, to achieve the effects of excellent biological properties, excellent biological activity, and slow degradation rate

Inactive Publication Date: 2009-05-13
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still some defects in the application of this material, which are mainly reflected in the following aspects: First, although this calcium phosphate bone cement solidifies quickly, its strength after solidification is very low (about 10MPa), which cannot meet the needs of teeth. The mechanical requirements of tissue repair materials; secondly, this material is similar to calcium phosphate ceramics, and has poor ability to induce bone-like apatite deposition, resulting in low bonding strength between materials and tissues; finally, due to the calcium oxide component in the composition Has a relatively high solubility and therefore causes a rapid increase in the pH of the environment above 10.0, limiting the application of this material to the field of endodontic canal filling
In addition, there is a high probability that the material will collapse in body fluids during treatment, leading to failure of the treatment

Method used

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  • Hydrogen phosphate/tricalcium silicate composite self-curing material with biological activity, preparation and uses thereof
  • Hydrogen phosphate/tricalcium silicate composite self-curing material with biological activity, preparation and uses thereof
  • Hydrogen phosphate/tricalcium silicate composite self-curing material with biological activity, preparation and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] 1) Blending liquid preparation

[0042] Weigh 1.0 g of analytically pure sodium bicarbonate and dissolve it in 99.0 mL of deionized water to obtain a 1.0% sodium bicarbonate solution, sterilize, seal it in a sterile bottle, and set aside.

[0043] 2) Preparation of calcium hydrogen phosphate / tricalcium silicate composite bone defect filling material:

[0044] Fully mix the calcium hydrogen phosphate / tricalcium silicate composite material powder with a tricalcium silicate content of 20wt.% and the blending solution at a liquid-solid mass ratio of 0.6:1 for 0.5-1 minute, pour into the mold, and heat at 37°C and 100% humidity conditions for more than 7 days, and then the mold is released to obtain calcium hydrogen phosphate / tricalcium silicate composite material balls for bone defect filling. The compressive strength of the pellet can reach more than 30MPa, and it also has good biological activity.

Embodiment 2

[0046] 1) Blending liquid preparation

[0047] Analytical pure disodium hydrogen phosphate (Na 2 HPO 4 12H 2 O) and sodium dihydrogen phosphate (NaH 2 PO 4 2H 2 O) preparing a sodium phosphate buffer solution with a pH value of 7.0-7.5, the concentration of the solution can be adjusted as required, and the range is 0.1-1.0 mol / L. Sterilize, seal in a sterilized bottle, and keep it for later use.

[0048] 2) Preparation of calcium hydrogen phosphate / tricalcium silicate composite self-curing material:

[0049] The calcium hydrogen phosphate / tricalcium silicate composite material powder with a tricalcium silicate content of 20wt.% and the blending solution are fully blended at a liquid-solid mass ratio of 0.6:1 for 0.5-1 minute to obtain a minimally invasive Therapeutic calcium hydrogen phosphate / tricalcium silicate composite self-curing material. The self-curing material can reach the initial setting in about 20 minutes after being injected into the defect site, and the ...

Embodiment 3

[0051] 1) Preparation of blending solution

[0052] The simulated body fluid is used as the blending solution, and the ion concentration of the simulated body fluid is shown in Table 2 (pH=7.25-7.4):

[0053] Table 2

[0054] Ion species Na + K + Mg 2+ Ca 2+ Cl - HCO 3 - HPO 4 2- ion concentration

mmol / L) 142.0 5.0 1.5 2.5 148.8 4.2 1.0

[0055] 2) Preparation of calcium hydrogen phosphate / tricalcium silicate composite degradable material

[0056] Fully blend the calcium hydrogen phosphate / tricalcium silicate composite material powder with a tricalcium silicate content of 30wt.% and the blending solution at a ratio of 0.5-1.5:1 to the liquid-solid mass ratio for 0.5-1 minute, inject the mold, and After curing for more than 7 days at 37° C. and 100% humidity, the mold is released to obtain a calcium hydrogen phosphate / tricalcium silicate solidified block material for bone defect filling. The main chemical composition of thi...

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Abstract

The invention relates to a bioactive dicalcium phosphate / tricalcium silicate compounded self-setting material and the preparation method and application thereof, and belongs to the field of medical biomaterials. The invention is a paste comprising a mixing liquid and bioactive dicalcium phosphate / tricalcium sulfate which are mixed with each other at a mass ratio of 0.5-1.5:1, with the percentage composition of the mass of tricalcium silicate in the composite powder equaling 1-50% and the selected mixing liquid being deionized water, a simulated body fluid, an inorganic salt solution, or an organic matter solution. Compared with the prior materials, the invention has the characteristics of relatively high strength, random moulding, self-setting and biological activity, and can achieve the effect of inducing the generation of bone-like apatite. Moreover, the ratio of mechanical property to biological activity of the material provided by the invention is similar to that of calcium phosphate bone / tooth defect recovery materials.

Description

[0001] field of invention [0002] The invention relates to a bioactive calcium hydrogen phosphate / tricalcium silicate composite self-curing material, its preparation and application, and belongs to the field of medical biomaterials. Background technique [0003] In the mid-1980s, Brown and Chow invented a new type of self-curing bioactive bone repair material - calcium phosphate cement (Calcium Phosphate Cement; CPC). CPC refers to a calcium phosphate (Calcium Phosphate, CP) material that is mixed with several phosphate powders and a blending solution, undergoes a hydration reaction at room temperature or human body temperature, and can spontaneously solidify. CPC is different from ceramic materials. Its preparation, molding and clinical trial are integrated. It can be shaped arbitrarily according to the bone defect site, and the operation is convenient. In recent years, with the deepening and expansion of calcium phosphate bone cement research, the application of calcium p...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/02A61K6/033A61K6/027A61K6/838
Inventor 常江郇志广
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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