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Nano coating combined with micropore surface method for modifying endovascular stent

A nano-coating and stent technology, used in coatings, stents, medical science and other directions, can solve the problems of vascular endothelial injury and the incomplete understanding of the mechanism of postoperative ISR, and achieve a simple and easy-to-use material for inhibiting intimal hyperplasia. Effect of surface properties, good blood compatibility

Inactive Publication Date: 2009-08-05
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The mechanism of postoperative ISR is still not fully understood.
Studies have found that the possible mechanism is as follows: the implantation of the stent causes the damage of the vascular endothelium due to the dilation of the diseased blood vessel, and the damage of the elastic fiber layer extends to the arterial intima, which leads to the migration and proliferation of smooth muscle cells to the injured site, and the excessive intima The proliferation eventually leads to the ISR
In addition, stent implantation will cause the adsorption and deposition of fibrinogen and platelets on the surface of the stent, resulting in the formation of thrombus, which is also one of the possible reasons for triggering ISR.

Method used

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  • Nano coating combined with micropore surface method for modifying endovascular stent
  • Nano coating combined with micropore surface method for modifying endovascular stent
  • Nano coating combined with micropore surface method for modifying endovascular stent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] (1) Immerse the NiTi alloy or 316L stainless steel intravascular stent in acetone solution, ultrasonically clean it for 5 minutes, take out the stent and rinse it with distilled water three times;

[0022] (2) Configure 30% HNO 3 Solution (volume percentage);

[0023] (3) Immerse the cleaned stent into 30% HNO 3 In the solution container, place the container in a water bath at a constant temperature of 40°C for 24 hours.

[0024] (4) Take out the stent, clean it ultrasonically with acetone for 5 minutes and clean it three times with distilled water, and dry it at room temperature;

[0025] (5) Place the stent as a cathode material figure 1 On the stainless steel substrate ① in the bell-type plasma reactor;

[0026] (6) Turn on the first and second vacuum pumps ② and ③ to extract the vacuum, and then pass the TMS or O and O into the bell plasma reaction chamber ⑤ through the flow rate controller ④ 2 Adjust the pressure in the reaction chamber through the pressure controller...

Embodiment 2

[0033] Steps (1)-(5) are the same as in Example 1;

[0034](6) Turn on the first and second vacuum pumps ② and ③ to extract vacuum, and then pass the TMS and CH into the bell plasma reaction chamber ⑤ through the flow rate controller ④ 4 And O 2 . SiO can be obtained according to the realization method shown in Table 2 x :H nano coating;

[0035] Table II

[0036] In turn

Incoming monomer Flow rate

(sccm) Reaction pressure (mtorr)

Reaction time (min)

DC power supply

Power (W) TMS 2 25 2 5 CH 4 1 25 1 5 O 2 2 50 2 5

[0037] (7) Determination of deposited SiO x :H nano-coating thickness and water contact angle; SEM, AFM measured the surface morphology of the stent before and after modification, FTIR measured the surface chemical group, the in vitro endothelial cell adhesion experiment was equivalent to Example 1.

[0038] The average roughness Ra of the surface of the scaffold material obtained by the methods of the above-men...

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Abstract

The invention provides an endovascular stent modification method with the combination of a nanometer coating and a microporous surface, which comprises the steps of: forming micropores on the surface of an implantable medical device, namely an NiTi alloy or 316L stainless steel endovascular stent, preparing a layer of SiOx: H nanometer coating on the surfaces of the micropores, ensuring that the stent can be quickly endothelialized after implanted into a human body and has good blood compatibility and corrosion resistance, and selecting a trimethyl silane (TMS) monomer or mixed gas of the trimethyl silane monomer and oxygen O2 as reaction gas aerated for preparing the nanometer coating, or orderly aerating the TMS, CH4 and O2 gas monomers respectively. The stent modified by the method can be quickly endothelialized after implanted into a pathological change position, and effectively reduce the formation of thrombus; and the biocompatibility (such as corrosion resistance, and the like) of the stent is obviously superior to that of an unmodified stent, so that the incidence rate of ISR is reduced after the sent is implanted through surface modification technology based on stents which have come into the market.

Description

Technical field [0001] The invention relates to the technical field of surface modification of cardiovascular implanted medical devices, in particular to the modification technique of NiTi alloy and 316L stainless steel intravascular stents, and belongs to the technical field of medical devices. Background technique [0002] Nowadays, the harm caused by coronary heart disease to people is becoming more and more prominent. Stent implantation has become the first choice for interventional treatment of coronary heart disease due to its many advantages, such as easy operation, low patient pain, low risk, and quick postoperative recovery. According to statistics from the Ministry of Health, the number of patients requiring cardiovascular surgery in my country has reached 4 million. Metal stents will produce 10%-50% in-stent restenosis (ISR) within 6 months after implantation. At present, the mechanism of postoperative ISR is not fully understood. Studies have found that the possible m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/56A61L27/30A61F2/82A61L27/04A61L27/06
Inventor 王贵学沈阳张勤唐朝君俞青松
Owner CHONGQING UNIV
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