Process for preparing magnetic resonance visibility strengthened film based on layered assembly technology

A technology of magnetic resonance visibility and layered assembly, applied in coatings, medical science, diagnosis, etc., can solve problems such as the difficulty of modifying magnetic nanoparticles, and achieve the effect of uniform particle size

Inactive Publication Date: 2010-04-14
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is very difficult to modify magnetic nanoparticles directly on the surface of hydrophobic plastics. If polymer-coated magnetic nanoparticles are used, it is possible to achieve their deposition on hydrophobic substrates.

Method used

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  • Process for preparing magnetic resonance visibility strengthened film based on layered assembly technology
  • Process for preparing magnetic resonance visibility strengthened film based on layered assembly technology
  • Process for preparing magnetic resonance visibility strengthened film based on layered assembly technology

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Embodiment 1: the preparation of polymer microgel

[0051] Add 1 mL of chromium trioxide aqueous solution (5 mg / mL) to 4 mL of hyaluronic acid (HA) aqueous solution (concentration: 40 mg / mL), and stir for 12 hours at room temperature in the dark. Then 10 mL of polyvinylimine (PEI) aqueous solution (concentration of 40 mg / mL) was added thereto, and sodium hydroxide was gradually added to the solution until the pH value was 10 (use a pH meter to detect the pH value of the solution). At this time, the aldehyde groups obtained after hyaluronic acid oxidation will directly chemically cross-link with the amino groups of polyvinylimine in aqueous solution to form polyvinylimine-hyaluronic acid microgels (PEI-H microgels). The product PEI-H microgels aqueous solution was dialyzed for three days using a dialysis bag with a cut-off molecular weight of 8000 to remove impurity ions (impurity ions include: sodium ions, chromium ions, etc.), and diluted to 100mL with deionized water ...

Embodiment 2

[0054] Embodiment 2: Preparation of microgel containing ferric oxide nanoparticles

[0055] Mix 0.016g ferric chloride (0.1mmol), 0.0064g ferric chloride (0.05mmol) and the polyvinylimine-hyaluronic acid microgel (5.6mg / mL) that 10mL embodiment 1 prepares, stir 20min . Add 0.5mL ammonia water (14mol / L) to the above mixture for hydrolysis, and continue stirring for 10min to obtain a uniform black magnetic microgel aqueous solution (Fe 3 o 4 @PEI-H microgels). The concentration of the synthesized magnetic microgel aqueous solution is 6.8mg / mL, and the mass content of ferric iron tetroxide nanoparticles in the magnetic microgel is 17%. Nitrogen protection was always used during the reaction. The solution must be sealed and stored at 4°C. Such as figure 1 As shown, Fe 3 o 4 @PEI-H microgels do not show magnetism when the external magnetic field is zero, and show magnetism when the external magnetic field is not zero, so the microgel containing ferroferric oxide nanoparticl...

Embodiment 3

[0059] Example 3: Preparation of microgel multilayer film containing ferric oxide nanoparticles

[0060] Precursor film preparation was achieved by soaking polyethylene substrates in PEI-H microgels (1 mg / mL, pH = 10) and polyacrylic acid (PAA) solution (1 mg / mL, pH = 10) for 15 min each. Then alternately soak in Fe 3 o 4@PEI-H microgels (1 mg / mL, pH = 10) and PAA solution (1 mg / mL, pH = 10) for 15 minutes each, repeating this step to obtain a multilayer film containing ferric oxide nanoparticles. After each step of soaking, it is washed with water and N 2 The process of drying. figure 2 The growth process of multilayer films containing Fe3O4 nanoparticles was monitored using a quartz microweight balance. It shows that the multilayer film shows a linear growth trend, that is, the quality of the multilayer film increases linearly with the increase of the deposited layers.

[0061] In this example, the concentrations of PEI-H microgels and PAA solutions are both 1 mg / mL an...

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Abstract

The invention belongs to the technical field of magnetic resonance imaging and particularly relates to a process for preparing magnetic resonance visibility strengthened multilayer films containing magnetic nano-particles on a hydrophobic substrate by utilizing the layered assembly technology. The magnetic resonance visibility strengthened films not only have fine magnetic resonance imaging signals, but also can be prepared on a surface of a hydrophobic plastic interventional catheter, thereby realizing visualization of the plastic interventional catheter. The magnetic resonance visibility strengthened films prepared by combining the layered assembly technology can not only be prepared on flat substrates, but also be conveniently prepared on the surfaces of interventional devices in complex shapes, thereby realizing visualization of the devices in magnetic resonance diagnosis. Additionally, the magnetic resonance visibility strengthened films have fine stability and simple preparing process; the preparing process is completely based on aqueous liquor; raw materials used by the process are innocuous and harmless, thereby the process can be hopefully applied to clinical magnetic resonance diagnosis and adjuvant therapy.

Description

technical field [0001] The invention belongs to the technical field of magnetic resonance imaging, and in particular relates to a method for preparing a magnetic resonance visibility-enhancing multilayer film containing magnetic nanoparticles on a hydrophobic substrate by using layered assembly technology. This multilayer film has a strong magnetic resonance signal, such as can be modified on the surface of hydrophobic plastic interventional catheters, so as to realize the visualization of interventional magnetic resonance therapy. Background technique [0002] Interventional MRI (Interventional MRI) is a new technology developed in recent years, the application of MRI-guided equipment can easily achieve the purpose of diagnosis and treatment (Eur.J.Radiol.2005, 56, 130). Its main features include: 1) real-time or near-real-time image display; 2) volumetric imaging; 3) interactive volumetric imaging and data display; 4) free navigation within the surgical volume; 5) combinat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L29/08A61L29/04A61L29/18A61M39/00A61B5/055
Inventor 孙俊奇王旭
Owner JILIN UNIV
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