Tinidazole/miconazole nitrate/neomycin compound vaginal suppository and preparation method thereof

Abstract

The invention belongs to the field of pharmaceutic preparation and relates to a tinidazole / miconazole nitrate / neomycin compound vaginal suppository and a preparation method thereof. The vaginal suppository consists of tinidazole, miconazole nitrate, neomycin sulfate, suppository substrate and an acidifier with curative doses, and can be used for multiple kinds of colpitis. The preparation method comprises the following steps: heating and smelting a suppository substrate and an acidifier with prescription doses; adding fine powders of the tinidazole, the miconazole nitrate and the neomycin sulfate filtered by a 80-mesh sieve into the mixture; quickly stirring the mixture till the mixture is about to be solidified; filling the mixture into a suppository film; and solidifying, scraping, taking out and packaging or directly filling the mixture into a dual-aluminum foil suppository bag. The prepared tinidazole / miconazole nitrate / neomycin compound vaginal suppository has scientific and novel prescription, is directly acted on a pathological part, has high medicament concentration on local parts, overcomes the gastrointestinal upset caused by oral administration, is convenient for patients to use, improves the treatment effect and reduces the toxicity and side effect. The preparation process is simple, has no special requirement on preparation environment, has low cost and stable quality of products and is suitable for industrialized mass production.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a tinidazole / miconazole nitrate / neomycin compound vaginal suppository and a preparation method thereof. Background technique [0002] Tinidazole has anti-protozoa and obligate anaerobic effects, and has inhibitory effects on protozoa such as Trichomonas vaginalis, Entamoeba histolytica and Giardia lamblia, and has an inhibitory effect on most anorexia bacteria and Bacteroides fragilis , Bacteroides melanin, other Bacteroides, Clostridium, fungi, Fusobacterium, Haemophilus vaginalis, Peptococcus, Peptostreptococcus and Weschia cocci have inhibitory or killing effects. It is suitable for trichomonal vaginitis and bacterial vaginosis caused by sensitive anaerobic bacteria. There are currently unilateral suppository applications. [0003] Miconazole nitrate is a broad-spectrum antifungal drug, which has antibacterial effect on various fungi, especially Candida, and also has...

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Problems solved by technology

[0005] At present, both tinidazole and miconazole nitrate have suppositories on the market, but neomycin sulfate has not been used in suppositories, and there is no relevant report on the preparation of suppositories by combining the three

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