Extrinsic analog enzyme type bio-molecular damage antagonist and preparation method thereof

A biomolecule and enzyme-mimicking technology is applied in the field of exogenous enzyme-mimicking biomolecule damage antagonists and their preparation, which can solve the problems of high preparation process and cost, expensive raw materials, etc. simple effect

Inactive Publication Date: 2012-08-08
JIMEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These active substances are natural and effective, but the raw materials are expensive, and the extraction process requires solvent extraction, separation and purification, and the preparation process and cost are relatively high.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: Component A is composed of 0.03% α-N-amino-D-glucose, 0.02% chitinase, 2.5% acetic acid by volume, and the rest is water. Component B is composed of 0.015% succinic acid and 0.015% o-hydroxybenzoic acid; component C is composed of 0.03% copper sulfate and 0.001% zinc sulfate.

Embodiment 2

[0021] Example 2: Component A is composed of 0.02% chitosan, 0.01% chitosanase, 0.2% acetic acid by volume and the rest is water. Component B is composed of 0.015% citric acid and 0.002% o-hydroxybenzoic acid; component C is composed of 0.02% copper chloride and 0.001% manganese sulfate.

Embodiment 3

[0022] Example 3: Component A is composed of 0.025% chitosan acylated derivatives, 0.003% a-amylase, 0.02% formic acid by volume fraction, and the rest is water. Component B is composed of 0.025% succinic acid and 0.004% methyl salicylate; component C is composed of 0.025% copper sulfate and 0.002% zinc sulfate.

[0023] 2. Preparation method

[0024] Preparation method 1:

[0025] For the preparation of component A, add 2.5ml of glacial acetic acid to a conical flask containing 100g of distilled water, stir well, then add 0.03g of α-N-amino-D-glucose and 0.02% chitinase in sequence. Stir until dissolved, and enzymatically hydrolyze in a water bath at 50°C for 18 hours. Stand at room temperature for 5 hours; (2) add component B, that is, a mixture of 0.015g succinic acid and 0.015g o-hydroxybenzoic acid, and stir until dissolved; (3) add component C, that is, a mixture of 0.03% copper sulfate, 0.001 % zinc sulfate mixture, fully stirred for 3.5 hours, stood in a water bath ...

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PUM

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Abstract

The invention discloses an extrinsic analog enzyme type bio-molecular damage antagonist, which consists of alpha-N-amino-D-glucose or derivates of the alpha-N-amino-D-glucose, hydrolase of polysaccharide and derivates of the polysaccharide, acetic acid or formic acid and distilled water, binary or ternary organic acid, micro-molecular phenols and esters or derivates of fatty acid, water soluble cupric salts, water soluble zinc salts or manganese salts. In the invention, the extrinsic analog enzyme type bio-molecule antagonist, which has a natural metal analog enzyme (SOD) activity and can effectively antagonize the exogenous damages to DNA and protein macromolecules, is prepared by using N-acetyl-beta-glucosamine which is the catabolite of abundant natural polymer polysaccharide as the main material and micro-molecular organic acid, phenols and derivates thereof and common inorganic salts as the auxiliary materials and by using a simple process. The extrinsic analog enzyme type bio-molecule antagonist has the characteristics of readily available raw materials, simple process and no toxicity.

Description

technical field [0001] The present invention relates to one, in particular to an exogenous mimetic enzyme-type biomolecule damage antagonist and a preparation method thereof. Background technique [0002] DNA and protein are important biological macromolecules that constitute the basic material of life. Studies in recent years have confirmed that premature aging, shortened lifespan, dermatitis, blood diseases, tumors, and cancers, including human beings, are closely related to the damage of biological macromolecules. Studies have confirmed that physical factors such as ultraviolet radiation, ionizing radiation, and ultrasonic waves, as well as chemical factors such as photosensitizers and free radicals, can cause damage to biological macromolecules. Searching for substances that can effectively antagonize the damage of biological macromolecules has become a hot spot in the fields of biology, biomedicine, chemistry, and health care products in recent years. At present, ther...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/34A61K33/32A61K33/30A61K31/7008A61P39/06A61P39/00
Inventor 马建华
Owner JIMEI UNIV
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