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Compound tylosin injection for animals and preparation method thereof

A technology of tylosin and injection, applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, antibacterial drugs, etc., can solve the problem of incomplete curative effect, achieve long action time, short course of treatment, and stimulating effect small effect

Inactive Publication Date: 2012-01-11
陈建波
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The dose of the injection is accurate and the effect is reliable, unlike the internal medicine that may be affected by digestive juices, food, etc., and the dose used cannot fully produce the curative effect

Method used

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  • Compound tylosin injection for animals and preparation method thereof
  • Compound tylosin injection for animals and preparation method thereof
  • Compound tylosin injection for animals and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] A compound tylosin injection for veterinary use, the components are as follows:

[0040] Tylosin 10g, doxycycline hydrochloride 5g, trimethoprim 3.75g, aminophylline 4g, dexamethasone sodium phosphate 0.05g, magnesium chloride 2.35g, sodium formaldehyde sulfoxylate 0.25g, sodium thiosulfate 0.15g, α-pyrrolidone 30g, N,N-dimethylformamide 15g, propylene glycol 15g, water for injection 20g.

[0041] The above-mentioned veterinary compound tylosin injection is prepared by the following steps:

[0042] 1) After dissolving 2.35 g of magnesium chloride in 3 g of water for injection, add 30 g of α-pyrrolidone, then add 5 g of doxycycline hydrochloride, stir and dissolve to obtain doxycycline hydrochloride solution;

[0043] 2) After dissolving 0.25 g of sodium formaldehyde sulfoxylate in 3 g of water for injection, add it to the solution prepared in step 1), then add 2 g of ethanolamine and stir evenly, then add 10 g of tylosin, stir to dissolve, and obtain Tylosin mixed sol...

Embodiment 2

[0067] A compound tylosin injection for veterinary use, the components are as follows:

[0068] Tylosin 5g, doxycycline hydrochloride 3g, Shenoxybenz 2g, aminophylline 3g, dexamethasone sodium phosphate 0.02g, magnesium chloride 1.41g, sodium formaldehyde sulfoxylate 0.1g, sodium thiosulfate 0.1 g, α-pyrrolidone 20g, N,N-dimethylformamide 20g, propylene glycol 20g; water for injection 30g;

[0069] The preparation steps were the same as in Example 1 to obtain compound tylosin injection for veterinary use, with a pH of 8.5.

[0070] The present embodiment clinical treatment effect is as follows:

[0071] Table 1 Clinical therapeutic effect of compound tylosin injection

[0072] animal

[0073] Table 2 The present invention and tylosin injection clinical treatment comparative test result

[0074]

[0075] The stability test of product is with embodiment 1.

[0076] when saving

[0077] From the above data, it can be seen that after 3 months of acceler...

Embodiment 3

[0079] A compound tylosin injection for veterinary use, the components are as follows:

[0080] Tylosin 15g, doxycycline hydrochloride 7g, trimethoprim 3g, aminophylline 3g, dexamethasone sodium phosphate 0.1g, magnesium chloride 3.3g, sodium formaldehyde sulfoxylate 0.25g, sodium thiosulfate 0.15 g, α-pyrrolidone 40g, N,N-dimethylformamide 15g, propylene glycol 15g; water for injection 20g;

[0081] The preparation steps were the same as in Example 1 to obtain compound tylosin injection for veterinary use, with a pH of 8.7.

[0082] The present embodiment clinical treatment effect is as follows:

[0083] Table 1 Clinical therapeutic effect of compound tylosin injection

[0084] animal

[0085] Table 2 The present invention and tylosin injection clinical treatment comparative test result

[0086]

[0087] The stability test of product is with embodiment 1.

[0088]

[0089] It can be seen from the above data that after 3 months of accelerated prod...

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Abstract

The invention relates to compound tylosin injection for animals and a preparation method thereof. The injection consists of tylosin, doxycycline hydrochloride, trimethoprim, aminophylline, dexamethasone sodium phosphate, organic solvent and injection water. As a dedicated compound preparation for animals, the injection has special effect for treating respiratory tract infection caused by livestock and poultry sensitive bacteria and mycoplasmosis of pigs and poultry. The method has the advantages of convenient use, short course of treatment, low drug resistance and the like.

Description

technical field [0001] The invention relates to a veterinary compound tylosin injection, in particular to an injection made of tylosin, doxycycline hydrochloride, trimethoprim, aminophylline and dexamethasone sodium phosphate and its preparation method. Background technique [0002] Tylosin (Enrofloxacin), a representative of a new generation of quinolones, is designated as a special drug for animals. It has a significant effect on various infections caused by a variety of bacteria, and its lethality against various mycoplasma is significantly higher than that of Other quinolone drugs and various drugs such as tylosin and tiomycin, which have been used for many years, have broad spectrum, high efficiency, low toxicity, good absorption and convenient administration. The MIC against most strains is lower than 1 μg / ml, and it has obvious post-antibacterial effect (PAE) on sensitive bacteria. It is suitable for various infectious diseases of digestive system, respiratory syste...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K31/65A61K31/505A61K31/522A61K31/661A61K9/08A61P31/04A61P11/00A61P19/02
Inventor 陈建波陈抗
Owner 陈建波
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