Method for synthesizing squalene

A synthesis method and technology of squalene, applied in chemical instruments and methods, hydrocarbons, hydrocarbons, etc., can solve the problems of explosion of polymerization reaction, unfavorable industrial production, harsh reaction requirements of sodium acetylene, etc., and improve safety. , The advantages of industrialization are obvious and the operation is convenient.
CN101891579AInactive Publication Date: 2010-11-24SHANGYU NHU BIOCHEM IND +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGYU NHU BIOCHEM IND
Publication Date
2010-11-24
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a method for synthesizing squalene. Certain conventional synthetic routes are too long and require operation at an extremely low temperature; and certain conventional synthetic routes have harsh requirements on reactions and have the risk of polymerization reaction explosion so that the conventional synthetic routes are not beneficial for industrial production. The method comprises the following steps of: performing a reaction of dichlorobutane serving as a raw material and triethyl phosphite to generate phosphonate; and performing a Wittig-Horner reaction of the phosphonate and geranylacetone to obtain the squalene. The raw material in the invention does not contain any substance which is easy to be polymerized so that safety is enhanced greatly; and a formed double bond has trans-selectivity and high overall yield so that a synthesis route which has very remarkable industrial advantages is achieved.
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Description

technical field

[0001] The invention relates to polyterpenoids, especially a method for synthesizing squalene. Background technique

[0002] The chemical name of squalene is: 2, 6, 10, 15, 19, 23-hexamethyl-2, 6, 10, 14, 18, 22-tetracosahexaene, which is a long-chain triterpenoid . Squalene is a colorless or slightly yellow oily liquid with a pleasant smell, and becomes viscous into linseed oil after absorbing oxygen, with a specific gravity of 0.8584 g / cm 3 , melting point -75°C, boiling point about 330°C (atmospheric pressure, decomposed), 280°C / 2.27KPa, 285°C / 3.30KPa, 240°C-242°C / 533Pa, flash point 110°C, refractive index n D 20 1.4965, viscosity 0.012Pa·s, soluble in ether, petroleum ether, acetone and carbon tetrachloride, slightly soluble in ethanol and glacial acetic acid, insoluble in water.

[0003] Squalene is a lipid unsaponifiable substance, which has many physiological functions such as improving the activity of superoxide dismutase (SOD) in the body, enhanc...

Claims

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