Preparation method for preparation containing glucosamine and application thereof

A technology of glucosamine and glucosamine hydrochloride, which is applied in the field of preparation of glucosamine-containing preparations, and can solve the problems of small side reactions and the like

Inactive Publication Date: 2011-01-19
南京威尔曼药物研究所有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, NSAID s drugs relieve symptoms more quickly, while chondroprotective drugs have a slightly lower therapeutic effect, but they have a mild onset effect and less side effects after long-term use

Method used

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  • Preparation method for preparation containing glucosamine and application thereof
  • Preparation method for preparation containing glucosamine and application thereof
  • Preparation method for preparation containing glucosamine and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: Glucosamine Hydrochloride Capsules (Specification: Glucosamine Hydrochloride 0.24g)

[0013] Glucosamine Hydrochloride 240g

[0014] Magnesium chloride 100g

[0015] Microcrystalline Cellulose 50g

[0016] 5% PVP K30 (70% ethanol) appropriate amount

[0017] Magnesium Stearate 5g

[0018]

[0019] Makes 1000 capsules

[0020] Preparation process: crush each raw and auxiliary material through an 80-mesh sieve, take the prescribed amount of glucosamine hydrochloride, magnesium chloride and microcrystalline cellulose and mix evenly, add 5% PVP K30 (70% ethanol) soft material, 20 mesh granulation, 40 ~ 50 ℃ drying, 16 mesh granulation, adding magnesium stearate and mixing with the above granules, filling No. 1 capsule.

Embodiment 2

[0021] Embodiment 2: compound glucosamine sulfate chewable tablet (specification: glucosamine sulfate sodium chloride double salt 0,314g / chondroitin sulfate 0.2g)

[0022] Glucosamine Sulfate Sodium Chloride Double Salt 314g

[0023] Chondroitin sulfate (calculated as pure product) 200g

[0024] Calcium Lactate 300g

[0025] Lactose 200g

[0026] Aspartame 15g

[0027] Malic acid 10g

[0028] 2% HPMC (60% ethanol solution) appropriate amount

[0029] Orange flavor 10g

[0030] Magnesium Stearate 10g

[0031]

[0032] Made into 1000 pieces

[0033] Preparation process: each raw and auxiliary material is crushed through an 80-mesh sieve, and the prescribed amount of glucosamine sulfate sodium chloride double salt, chondroitin sulfate, calcium lactate, lactose, aspartame and malic acid are mixed evenly, and 2% HPMC ( 60% ethanol solution) to make soft materials, granulate with 16 mesh, dry at 40-50°C, granulate with 12 mesh, add magne...

Embodiment 3

[0034] Embodiment 3: Glucosamine sulfate freeze-drying (glucosamine sulfate sodium chloride double salt 0.5025g)

[0035] Glucosamine Sulfate Sodium Chloride Double Salt 502.5g

[0036] Lidocaine Hydrochloride 10g

[0037] Diethanolamine 20g

[0038] Mannitol 100g

[0039] Hydrochloric acid amount

[0040] Add water for injection 3000ml

[0041]

[0042] Makes 1000 bottles

[0043] Preparation process: Take 80% water to prepare 0.04mol / L hydrochloric acid solution, add glucosamine sulfate sodium chloride double salt and stir to make it completely dissolved; add prescription amount of lidocaine hydrochloride, mannitol and diethanolamine, stir until completely dissolved, add water to a sufficient amount. Add 0.05% activated carbon, stir for 15-30 minutes, decarbonize, filter through 0.45um, 0.22um microporous membranes until clarified; fill in 3ml portions, and freeze-dry. The freeze-drying process includes: a pre-freezing process for 2-10 hours; a ...

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Abstract

The invention discloses a preparation method for preparation containing glucosamine and an application thereof. The preparation is characterized in that the major component is one or the combination of more of the glucosamine, glucosamine hydrochloride, glucosamine sulfate sodium chloride double salt or potassium chloride double salt, and chondroitin sulfate. The preparation method is simple, convenient and time-saving to operate and is easy for large industrialized production.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and particularly relates to a preparation method and application of a preparation containing glucosamine. Background technique [0002] Amino dextran is a natural sugar derived from chitin, which is the main component of the cartilage matrix. By changing its side chain structure, it is easier to combine with water in the articular cartilage to maintain the lubrication of the joint cavity and buffer pressure. It has a certain protective effect on damaged chondrocytes and can be artificially synthesized. Currently, glucosamine, glucosamine hydrochloride, glucosamine sulfate sodium chloride double salt or potassium chloride double salt are commonly used. Glucosamine is one of the smallest units that make up polyglucosamine, and it forms polyglucosamine with uronic acid, including chondroitin sulfate, keratan sulfate, dermatan sulfate and hyaluronic acid. [0003] Anti-inflammatory drugs c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/737A61K31/7008A61K33/42A61K33/14A61K33/06A61K33/26A61K33/04A61K9/00A61K9/19A61K9/08A61P19/04A61P19/02A61K31/191A61K31/19A61K31/194
Inventor 任金山石涛张瑾赵晖邹爱峰魏小荣徐健峰张敏廖燕燕
Owner 南京威尔曼药物研究所有限公司
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