Medicine-carrying biodegradable vena cava filter and preparation method thereof

A vena cava and drug-loading technology, applied in the field of bioengineering, can solve the problems of permanent filter metal foreign bodies, high incidence, thrombosis of metal filters, etc., achieve adjustable degradation time, reduce complications, and improve mechanical properties Effects on performance and biocompatibility

Inactive Publication Date: 2011-06-08
FUDAN UNIV SHANGHAI CANCER CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The permanent metal vena cava filter has the following difficult problems: 1. The higher the emboli capture ability, the higher the incidence of long-term inferior vena cava occlusion; 2. The thrombogenicity o

Method used

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  • Medicine-carrying biodegradable vena cava filter and preparation method thereof
  • Medicine-carrying biodegradable vena cava filter and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0027] Example 1 Preparation of methacrylic acid anhydride sebacic acid (MSA)

[0028] Weigh 0.1 mol (20.2 g) of sebacic acid in a single-necked flask, add 0.25 mol (40 ml) of methacrylic anhydride (MA), place the flask in an oil bath, put in a tetrafluoromethane stirrer and start electromagnetic stirring to control the reaction The temperature is at 80°C. After reacting for about 1 hour, SA completely reacted and turned into a clear and transparent liquid. The reaction was continued for 0.5 hours to obtain a colorless and clear liquid. The reaction product was extracted three times with petroleum ether with a boiling range of 90-120°C, the lower layer was taken out of the colorless transparent liquid, and the residual petroleum ether, methacrylic anhydride and methacrylic anhydride were removed by distillation under reduced pressure at 80°C. The resulting colorless, transparent and viscous liquid is the product MSA.

Example Embodiment

[0029] Example 2 Preparation of methacrylic acid anhydride 1,6-bis(p-carboxyphenoxy)hexane (MCPH)

[0030] Dissolve 27.6g (0.2mol) p-hydroxybenzoic acid and 16g (0.4mol) sodium hydroxide in 300ml water, put them in a 500ml three-neck flask, add 24.6g (0.1m ol) dibromohexane dropwise with stirring (Added in 1hr) while heating to reflux, after 5hrs, 4g (0.1mol) sodium hydroxide solid was added, and refluxing was continued for 2 hours. The heating was stopped and the reaction was allowed to stand overnight. After suction filtration, the precipitate was washed with 40ml methanol and immediately dissolved in 100ml water. The solution was heated to 60-70°C and acidified with 6mol / L sulfuric acid until no white precipitate was produced. It was filtered while hot, and the precipitate was vacuum dried at 40°C to obtain 22.3 g (51%) of white powder. IR(YBr)v(cm'): 3300 (width, K AP-OH), 1675 (stilbic acid C=0), 1604, 1513 (benzene ring C=C), 1255, 1169 (aryl ether C-0) .

[0031] Weigh ...

Example Embodiment

[0032] Example 3

[0033] Weigh 5 g of methacrylic anhydride sebacic acid (MSA) and 5 g of methacrylic anhydride bis(p-carboxyphenoxy) hexane (MCPH), put them in a beaker, add 0.25 g of low molecular weight heparin and 0.25 g of urokinase g, then add 0.1g of polypeptide particles, 0.1g of the photoinitiator 2,2-dimethoxy-2-phenylacetophenone (DMPA), electromagnetic stirring for 30min, ultrasonic for 30min, pour into the glass mold, Irradiate for 5 minutes under a UV lamp with 365nm and 500W power to obtain columnar materials of different diameters, which can be cut into different lengths according to needs; PROSTENT 1 laser cutting machine designs graphics according to AlphaCAM (LICOM) graphic design software, and engraves the pipes under computer control Etched into a network structure; in PBS solution (phosphate buffer solution), the degradation time is determined to be 50 days.

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Abstract

The invention belongs to the technical field of biological engineering and relates to a medicine-carrying biodegradable vena cava filter and a preparation method thereof. In the invention, methacrylic acid anhydride sebacic acid with bioactivity and di-(p-carboxyl phenoxyl) fat alkyl are used as polymerization raw materials, and nano polypeptide used as a reinforcing material is ultrasonically dispersed into polymerized monomers to obtain a columnar polymer material of certain degradation time through photocuring or thermocuring; and the columnar polymer material is etched into a vena cava filter with a barrel-shaped structure by a cutting machine, wherein low molecular heparin is used as an anticoagulant drug and a urokinase thrombolysis drug. By carrying the drugs, the vena cava filter not only can play a role of mechanically blocking thrombus, but also can be used as a drug releasing platform of anticoagulants and thrombolytics, can reduce the thrombophilia of the drugs, avoid postcava blockage caused by filter imbedding, effectively reduce the dosage of anticoagulation and thrombolytics drugs of the whole body and reduce the incidence of corresponding complications.

Description

technical field [0001] The invention belongs to the technical field of bioengineering, and in particular relates to a drug-loaded biodegradable vena cava filter and a preparation method thereof. Background technique [0002] According to statistics, the incidence of pulmonary embolism (Pulmonary Embolism, PE) is second only to coronary heart disease and hypertension in cardiovascular diseases, and its mortality rate is second only to tumors and myocardial infarction. A group of autopsy data in my country confirmed that PE accounted for 11.0% of cardiovascular diseases, and PE accounted for the first place in pulmonary vascular diseases. According to relevant studies, vena cava filter can significantly reduce the incidence of recurrent PE. [0003] Studies have shown that 75% to 90% of pulmonary embolisms originate from thrombi in the deep veins of the lower extremities and the pelvic venous plexus. In order to prevent or reduce the occurrence of pulmonary embolism, traditi...

Claims

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Application Information

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IPC IPC(8): A61L31/12A61L31/16A61L31/14A61L33/10A61F2/01
Inventor 高群李文涛
Owner FUDAN UNIV SHANGHAI CANCER CENT
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