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Medicine-carrying biodegradable vena cava filter and preparation method thereof

A vena cava and drug-loading technology, applied in the field of bioengineering, can solve the problems of permanent filter metal foreign bodies, high incidence, thrombosis of metal filters, etc., achieve adjustable degradation time, reduce complications, and improve mechanical properties Effects on performance and biocompatibility

Inactive Publication Date: 2011-06-08
FUDAN UNIV SHANGHAI CANCER CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The permanent metal vena cava filter has the following difficult problems: 1. The higher the emboli capture ability, the higher the incidence of long-term inferior vena cava occlusion; 2. The thrombogenicity of the metal filter itself; 3. The permanent The fate of the filter as a metal foreign body in the body, etc.
[0008] At present, there are no reports about degradable vena cava filter in domestic and foreign literature

Method used

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  • Medicine-carrying biodegradable vena cava filter and preparation method thereof
  • Medicine-carrying biodegradable vena cava filter and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1 prepares methacrylic anhydride sebacic acid (MSA)

[0028] Weigh 0.1mol (20.2g) of sebacic acid into a single-necked flask, add 0.25mol (40ml) methacrylic anhydride (MA), place the flask in an oil bath, put a tetrafluoro stirring bar and start electromagnetic stirring to control the reaction The temperature is at 80°C. After about 1 hour of reaction, SA completely reacted and turned into a clear transparent liquid. The reaction was continued for 0.5 hour to obtain a colorless clear liquid. The reaction product was extracted three times with petroleum ether with a boiling range of 90-120°C, and the colorless transparent liquid in the lower layer was removed, and residual petroleum ether, methacrylic anhydride, and methacrylic anhydride were removed by vacuum distillation at 80°C. The obtained colorless transparent viscous liquid is the product MSA.

Embodiment 2

[0029] Example 2 Preparation of methacrylic anhydride 1,6-bis(p-carboxyphenoxy)hexane (MCPH)

[0030] Dissolve 27.6g (0.2mol) of p-hydroxybenzoic acid and 16g (0.4mol) of sodium hydroxide in 300ml of water, place in a 500ml three-necked flask, and add 24.6g (0.1mol) of dibromohexane dropwise under stirring (After adding 1 hr), heat to reflux at the same time, after 5 hr, add 4 g (0.1 mol) of sodium hydroxide solid, and continue to reflux for 2 hours. The heating was turned off and the reaction was allowed to stand overnight. Suction filtration, the precipitate was washed with 40ml of methanol, and immediately dissolved in 100ml of water. Heat the solution to 60-70°C and acidify it with 6mol / L sulfuric acid until white precipitate no longer occurs. Suction filtration while it was hot, and the precipitate was vacuum-dried at 40° C. to obtain 22.3 g (51%) of a white powder. IR (YBr) v (cm'): 3300 (broad, K AP-OH), 1675 (sorboxic acid C=0), 1604, 1513 (benzene ring C=C), 1255, 11...

Embodiment 3

[0033] Weigh 5 g of methacrylic anhydride sebacic acid (MSA) and methacrylic anhydride bis(p-carboxyphenoxy) hexane (MCPH) 5 g, put them into a beaker, add 0.25 g of low molecular weight heparin, 0.25 g of urokinase g, then add 0.1g of polypeptide particles, 0.1g of photoinitiator 2,2-dimethoxy-2-phenylacetophenone (DMPA), electromagnetic stirring for 30min, ultrasonication for 30min, pour into a glass mold, and 365nm, 500W UV lamp irradiation for 5 minutes, to obtain columnar materials with different diameters, which can be cut into different lengths according to needs; PROSTENT 1 laser cutting machine designs graphics according to AlphaCAM (LICOM) graphic design software, and engraves the tubes under computer control. etched into a network structure; in PBS solution (phosphate buffer solution), the degradation time was determined to be 50 days.

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Abstract

The invention belongs to the technical field of biological engineering and relates to a medicine-carrying biodegradable vena cava filter and a preparation method thereof. In the invention, methacrylic acid anhydride sebacic acid with bioactivity and di-(p-carboxyl phenoxyl) fat alkyl are used as polymerization raw materials, and nano polypeptide used as a reinforcing material is ultrasonically dispersed into polymerized monomers to obtain a columnar polymer material of certain degradation time through photocuring or thermocuring; and the columnar polymer material is etched into a vena cava filter with a barrel-shaped structure by a cutting machine, wherein low molecular heparin is used as an anticoagulant drug and a urokinase thrombolysis drug. By carrying the drugs, the vena cava filter not only can play a role of mechanically blocking thrombus, but also can be used as a drug releasing platform of anticoagulants and thrombolytics, can reduce the thrombophilia of the drugs, avoid postcava blockage caused by filter imbedding, effectively reduce the dosage of anticoagulation and thrombolytics drugs of the whole body and reduce the incidence of corresponding complications.

Description

technical field [0001] The invention belongs to the technical field of bioengineering, and in particular relates to a drug-loaded biodegradable vena cava filter and a preparation method thereof. Background technique [0002] According to statistics, the incidence of pulmonary embolism (Pulmonary Embolism, PE) is second only to coronary heart disease and hypertension in cardiovascular diseases, and its mortality rate is second only to tumors and myocardial infarction. A group of autopsy data in my country confirmed that PE accounted for 11.0% of cardiovascular diseases, and PE accounted for the first place in pulmonary vascular diseases. According to relevant studies, vena cava filter can significantly reduce the incidence of recurrent PE. [0003] Studies have shown that 75% to 90% of pulmonary embolisms originate from thrombi in the deep veins of the lower extremities and the pelvic venous plexus. In order to prevent or reduce the occurrence of pulmonary embolism, traditi...

Claims

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Application Information

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IPC IPC(8): A61L31/12A61L31/16A61L31/14A61L33/10A61F2/01
Inventor 高群李文涛
Owner FUDAN UNIV SHANGHAI CANCER CENT
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