Formula, preparation method and application of omeprazole sodium liposome composite medicament
A technology of omeprazole sodium lipid and liposome, which can be used in pharmaceutical formulation, liposome delivery, drug combination and other directions, can solve the problems of batch fluctuation, energy consumption and time-consuming, increasing leakage rate, etc., and achieve zero waste and three wastes. Emissions, plant saving, and the effect of improving the therapeutic index
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Embodiment 1
[0057] The raw material drug is a highly water-soluble liposome combination drug. The molar ratio of each effective raw material component of the standard is as follows:
[0058] 1. The raw material is omeprazole sodium 0.05
[0059] 2. Phospholipid raw materials are soybean lecithin and polyene phosphatidylcholine
[0060] Mole ratio 1:0.1 composition 0.50
[0061] 3. The antioxidant is reduced glutathione 0.01
[0062] 4. The molecular diluent of phospholipid membrane is dimercaprol 1.00
[0063] 5. The dispersant and excipient of liposome drug-carrying body is xylitol 2.00
[0064] 6. Surfactant is sodium dehydrocholate 0.01
[0065] 7. Ethanol 80% (v / v) (when dry, evaporate to the fullest) appropriate amount
[0066] 8. Phosphate buffer solution for injection 0.05M pH value 5.0-8.0 appropriate amount
[0067] 9. Equal volumes of water for injection (when dry, evaporate to the limit) and phosphate buffer for injection
[0068] The preparation method is as described abo...
Embodiment 2
[0070] The raw material drug is a highly water-soluble liposome combination drug. The molar ratio of each effective raw material component of the standard is as follows:
[0071] 1. The raw material is omeprazole sodium 0.20
[0072] 2. Phospholipid raw materials are soybean lecithin and polyene phosphatidylcholine
[0073] Mole ratio 1:0.1 composition 4.00
[0074] 3. The antioxidant is reduced glutathione 0.06
[0075] 4. The molecular diluent of phospholipid membrane is dimercaprol 6.00
[0076] 5. The dispersant and excipient of liposome drug-carrying body is xylitol 8.00
[0077] 6. Surfactant is sodium dehydrocholate 0.05
[0078] 7. Ethanol 80% (v / v) (when dry, evaporate to the fullest) appropriate amount
[0079] 8. Phosphate buffer solution for injection 0.05M pH value 5.0-8.0 appropriate amount
[0080] 9. Equal volumes of water for injection (when dry, evaporate to the limit) and phosphate buffer for injection
[0081] The preparation steps and methods are th...
Embodiment 3
[0083] The raw material drug is a highly water-soluble liposome combination drug. The molar ratio of each effective raw material component of the standard is as follows:
[0084] 1. The raw material is omeprazole sodium 0.15
[0085] 2. Phospholipid raw materials are soybean lecithin and polyene phosphatidylcholine
[0086] Mole ratio 1:0.1 composition 3.06
[0087] 3. The antioxidant is reduced glutathione 0.05
[0088] 4. The molecular diluent of phospholipid membrane is dimercaprol 5.60
[0089] 5. The dispersant and excipient of liposome drug-carrying body is xylitol 7.70
[0090] 6. Surfactant is sodium dehydrocholate 0.04
[0091] 7. Ethanol 80% (v / v) (when dry, evaporate to the fullest) appropriate amount
[0092] 8. Phosphate buffer solution for injection 0.05M pH value 5.0-8.0 appropriate amount
[0093] 9. Equal volumes of water for injection (when dry, evaporate to the limit) and phosphate buffer for injection
[0094] The preparation steps and methods are th...
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