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Method for preparing bezoar soft capsules

A technology of clearing and softening capsules, which is applied in the field of preparation of traditional Chinese medicine preparations. It can solve the problems of concentration change, high extraction temperature, troublesome post-processing, etc., and achieve the effects of reducing the loss of heat-sensitive components, improving extraction efficiency, and reducing extraction temperature.

Active Publication Date: 2013-08-21
TAIJI GRP CHONGQING FULING PHARM FACTORY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the above method, decoction, dipping, and percolation are used to extract the active ingredients of the prescription medicinal materials. The decoction and dipping methods have long extraction time, high extraction temperature, high energy consumption, easy loss of heat-sensitive components, and low recovery rate of active ingredients. Disadvantages such as troublesome post-processing; percolation method has disadvantages such as long extraction time, easy volatilization loss of ethanol during percolation process, resulting in concentration change, low recovery rate of active ingredients, etc.

Method used

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  • Method for preparing bezoar soft capsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Prescription: artificial bezoar 290g, mint 4.41kg, chrysanthemum 5.88kg, nepeta panicle 2.35kg, angelica dahurica 2.35kg, chuanxiong 2.35kg, gardenia 7.35kg, coptis 2.35kg, cork 1.47kg, scutellaria baicalensis 7.35kg, rhubarb 11.77kg, Alice 7.35kg, Radix Paeoniae Rubra 2.35kg, Angelica 7.35kg, Rehmannia glutinosa 9.41kg, Campanulaceae 2.35kg, Licorice 1.47kg, Gypsum 11.77kg, Borneol 1.47kg

[0041] The preparation method comprises the following steps:

[0042] a. Extraction of Forsythia, Peppermint and Nepeta

[0043] a1. Mix the prescribed amount of forsythia, mint and nepeta, and crush it into a coarse powder for later use;

[0044] a2. The medicinal powder obtained in step a1 is placed in a multifunctional extraction tank, and the volatile oil is extracted by straight-through steam distillation, and the distilled aqueous solution is collected in another device for subsequent use;

[0045] a3. Add water equivalent to 3 times the weight of the medicinal powder ob...

Embodiment 2

[0057] Prescription: artificial bezoar 290g, mint 4.41kg, chrysanthemum 5.88kg, nepeta panicle 2.35kg, angelica dahurica 2.35kg, chuanxiong 2.35kg, gardenia 7.35kg, coptis 2.35kg, cork 1.47kg, scutellaria baicalensis 7.35kg, rhubarb 11.77kg, Alice 7.35kg, Radix Paeoniae Rubra 2.35kg, Angelica 7.35kg, Rehmannia glutinosa 9.41kg, Campanulaceae 2.35kg, Licorice 1.47kg, Gypsum 11.77kg, Borneol 1.47kg

[0058] The preparation method comprises the following steps:

[0059] a. Extraction of Forsythia, Peppermint and Nepeta

[0060] a1. Mix the prescribed amount of forsythia, mint and nepeta, and crush it into a coarse powder for later use;

[0061] a2. The medicinal powder obtained in step a1 is placed in a multifunctional extraction tank, and the volatile oil is extracted by straight-through steam distillation, and the distilled aqueous solution is collected in another device for subsequent use;

[0062] a3. Add water equivalent to 2 times the weight of the powder obtained in st...

Embodiment 3

[0074] Prescription: artificial bezoar 290g, mint 4.41kg, chrysanthemum 5.88kg, nepeta panicle 2.35kg, angelica dahurica 2.35kg, chuanxiong 2.35kg, gardenia 7.35kg, coptis 2.35kg, cork 1.47kg, scutellaria baicalensis 7.35kg, rhubarb 11.77kg, Alice 7.35kg, Radix Paeoniae Rubra 2.35kg, Angelica 7.35kg, Rehmannia glutinosa 9.41kg, Campanulaceae 2.35kg, Licorice 1.47kg, Gypsum 11.77kg, Borneol 1.47kg

[0075] The preparation method comprises the following steps:

[0076] a. Extraction of Forsythia, Peppermint and Nepeta

[0077] a1. Mix the prescribed amount of forsythia, mint and nepeta, and crush it into a coarse powder for later use;

[0078] a2. The medicinal powder obtained in step a1 is placed in a multifunctional extraction tank, and the volatile oil is extracted by straight-through steam distillation, and the distilled aqueous solution is collected in another device for subsequent use;

[0079] a3. Add water equivalent to 4 times the weight of the medicinal powder ob...

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Abstract

The invention discloses a preparation method of Niuhuang Shangqing Soft Capsules, which adopts the integrated technology of membrane pressure filtration cycle extraction and separation to replace the decoction method, dipping method and percolation method to extract the active ingredients of prescription medicinal materials, which can not only simplify the process flow, but also greatly The production cycle is shortened, energy consumption is saved, environmental protection and waste residue utilization are beneficial, and the amount of extraction solvent ethanol can be reduced, and the recovery rate of active components can be greatly improved.

Description

technical field [0001] The invention belongs to the field of pharmacy and relates to a preparation method of a traditional Chinese medicine preparation. Background technique [0002] National drug standard YBZ01492003-2009Z records: Niuhuang Shangqing Soft Capsule has the effect of clearing heat and purging fire, dispersing wind and relieving pain, and is clinically used for headache, dizziness, red eyes and tinnitus, sore throat, Mouth sores, swollen and painful gums, dry stool and other symptoms, the curative effect is definite. The prescription consists of 2.9g artificial bezoar, 44.1g mint, 58.8g chrysanthemum, 23.5g nepeta, 23.5g angelica, 23.5g chuanxiong, 73.5g gardenia, 23.5g berberine, 14.7g phellodendron, 73.5g scutellaria, 117.7g rhubarb , forsythia 73.5g, red peony 23.5g, angelica 73.5g, rehmannia 94.1g, bellflower 23.5g, licorice 14.7g, gypsum 117.7g, borneol 14.7g, a total of 19 herbs. The preparation method is to grind borneol and artificial bezoar into fine...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/804A61K9/48A61P29/00A61P25/00A61P1/08A61P27/02A61P27/16A61P11/04A61P1/02A61P1/10A61K31/045A61K33/06A61K35/413
Inventor 冯天炯秦郁文刘世琪林榜建张晓静姜进母力房华容
Owner TAIJI GRP CHONGQING FULING PHARM FACTORY CO LTD
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