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Adapter-modified magneto-optic dual-function contrast agent and preparation method and application thereof

An aptamer and dual-function technology, applied in the field of biomedical materials, can solve the problems of difficult magnetic-optical dual-function, fluorescence quenching of fluorescent ligands, complex preparation process, etc., and achieve convenient operation, mild reaction conditions, and comprehensive synthesis methods. simple effect

Inactive Publication Date: 2013-03-06
SHANGHAI NORMAL UNIVERSITY
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Problems solved by technology

Coated with organic polymers, it is easy to cause particle agglomeration, and the solubility of nanoparticles is unstable
Ligand exchange method is time inefficient and complicated to prepare
After the magnetic nanoparticles prepared by the above-mentioned prior art are connected with luminescent materials, the most obvious disadvantage is that it is easy to cause the fluorescence quenching of the fluorescent ligands attached to the surface, which makes it difficult to achieve the purpose of magneto-optical dual function.
The disadvantages of the magneto-optical bifunctional nanoparticles prepared by the prior art are: 1. only have magnetic properties, and the optical properties are not stable; 2. the fluorescence of the luminous body is easily quenched; 3. there is no targeting to tumor cells
[0004] After extensive retrieval of domestic and foreign patent documents and publications, there is no method for preparing magneto-optical dual-functional nanoparticles identical to the present invention.

Method used

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  • Adapter-modified magneto-optic dual-function contrast agent and preparation method and application thereof
  • Adapter-modified magneto-optic dual-function contrast agent and preparation method and application thereof
  • Adapter-modified magneto-optic dual-function contrast agent and preparation method and application thereof

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Embodiment

[0034] (1) Preparation of surface oleylamine coordinated oil-soluble manganese tetraoxide nanoparticles:

[0035] Dissolve 0.4 g of manganese acetylacetonate precursor in 10.13 g of oleylamine, vacuumize, stir magnetically in a nitrogen atmosphere, heat rapidly to 180°C, and react at a constant temperature for 9 hours; cool to room temperature and then centrifuge; Continuous washing with water and ethanol for 3 to 6 times; vacuum drying; brown substance oil-soluble manganese tetraoxide nanoparticles on the surface coordinated by oleylamine. Its transmission electron microscope pattern is as figure 1 As shown, it shows that the nanoparticles of trimanganese tetraoxide have good monodispersity in cyclohexane, and the particle size is about 7nm.

[0036] (2) preparation prepares the hexanaphthene solution of surfactant:

[0037] Add 7 mL of α-(4-nonylphenyl)-ω-hydroxy-poly(oxy-1,2-diethylene) (30 mmol) (Igepal CO-520) surfactant into 50 mL of cyclohexane solution, Ultrasonic d...

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Abstract

The invention discloses an adapter-modified magneto-optic dual-function contrast agent and a preparation method and application thereof. The contrast agent comprises silicon dioxide-coated trimanganese tetroxide nanoparticles, wherein the diameters of trimanganese tetroxide nanoparticles are 6-8 nanometers; the thickness of a silicon dioxide coating layer is 8-12 nanometers; the surface of the silicon dioxide coating layer is provided with an amino group and is coupled with a rhodamine isothiocyanate molecule and dicarboxyl polyethylene glycol through the amino group; and the dicarboxyl polyethylene glycol is connected with an adapter with an amino group. The contrast agent obtained in the invention has high monodispersity, high biocompatibility and targeting property, can be taken as a good T1 magnetic resonance imaging contrast agent, has high targeting property on tumor cells, and has wide application value in the fields of medicaments and biology; and the preparation method provided by the invention has the advantages of very low requirements on equipment, convenient operation process, low prices of need raw materials and nuisanceless byproducts.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to an aptamer-modified magneto-optical dual-function contrast agent and a preparation method and application thereof. Background technique [0002] With the advancement of science and technology, the needs of people's lives and the development of nanotechnology, people's research on nanomaterials has penetrated into smaller and smaller scales and more and more functional characteristics. Magneto-optic dual-functional nanomaterials, with their good geomagnetic and luminescent properties and unique structure, integrate magnetism and luminescence, and are widely used in magnetism, fluorescence, biology, medicine and other fields; especially in ultra-high-density information storage , Biomolecular recognition, drug delivery and other aspects have extremely important applications, and have become a major research topic in the international scientific and technological circles. Biochemi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/18A61K49/06A61K49/00C12Q1/02
Inventor 杨仕平代安涛胡鹤安璐黄国胜张崇琨汪娟娟
Owner SHANGHAI NORMAL UNIVERSITY
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