42results about How to "Reaction conditions are readily available" patented technology

The invention relates to a method for preparing ethyl 2-oxo-4-phenylbutyrate, which comprises the following steps: (1) reacting beta-halogeno ethylbenzene with magnesium in a first aprotic solvent to obtain a Grignard solution containing a Grignard reagent; (2) reacting ethyl oxalyl monochloride with one or more of CuX, Li2CuX4 and CuCN.LiX in a second aprotic solvent to obtain a solution containing a copper acyl chloride salt compound; and (3) dropwise adding the Grignard solution in the solution obtained in step (2), persevering the temperature at -20-160 DEG C, enabling the Grignard reagent to react with the cooper acyl chloride salt compound to obtain a product solution after the reaction is finished, carrying out acidic hydrolysis and alkali neutralisation on the product solution in sequence, washing, drying and removing the solvent, and obtaining the ethyl 2-oxo-4-phenylbutyrate with the purity no less than 97% after high vacuum rectification. The invention has the advantages of good reaction selectivity, high yield, easily obtained raw materials, mild reaction conditions, convenient operation and low cost.

The invention relates to the field of lignin degradation, in particular to a nickel-cerium biochar catalyst and a preparation method and application thereof.The nickel-cerium biochar catalyst comprises biochar serving as a carrier and active components loaded on the biochar, and the active components comprise nickel and cerium; the content of nickel is 1-10 wt.%, the content of cerium is 1-10 wt.%, and the balance is charcoal. According to the application, the nickel-cerium biochar catalyst is applied to catalytic depolymerization of lignin. According to the nickel-cerium biochar catalyst, the raw material for preparing the biochar is lignin, the lignin widely exists in the nature, is low in obtaining cost, can be regenerated, can effectively reduce the depolymerization cost and is suitable for large-scale industrial application, and the nickel-cerium biochar catalyst is matched with a crude glycerine system, so that the nickel-cerium biochar catalyst is of great benefit to green utilization of an industrial byproduct crude glycerine, and is suitable for large-scale industrial application. The lignin depolymerization efficiency is high, the conversion rate of the lignin can reach 78% or above, the selectivity of guaiacol and derivatives thereof exceeds 82%, and the selectivity of the monomer guaiacol exceeds 41%.

The invention discloses a bionic dry-wet adhesive force self-adjusting dressing. The bionic dry-wet adhesive force self-adjusting dressing comprises the following components in parts by weight: 7-8 parts of styrene-isoprene-styrene block copolymer; 5-6 parts of high molecular weight polyisobutene; 10-12 parts of low molecular weight polyisobutene; 4-5 parts of tackifying resin; 0.5-0.7 part of anti-aging agent; 3-3.5 parts of naphthenic oil; 11-13 parts of sodium carboxymethyl cellulose; 3-3.5 parts of chitosan; and 3.2-5.5 parts of microcrystalline cellulose; the size of the microcrystalline cellulose is 20-50 [mu]m. According to the bionic dry-wet adhesive force self-adjusting dressing of the invention, due to addition of the microcrystalline cellulose, and the size and the shape of the dressing basically remain unchanged after the dressing is in contact with the surface of a wound due to hydrophobic and water-guiding effects of the microcrystalline cellulose, the hardness of the dressing after moisture absorption is improved, and the adhesive force of the dressing after moisture absorption is further improved; different adhesive forces are shown according to different dryness and wetness of the contact surface, so that the problem that the dressing is easy to soften and lose viscosity after absorbing moisture is solved, and the experience feeling of a patient is improved.

The invention discloses a synthetic method of a carbapenem antibiotic drug intermediate. By using (R)-3-hydroxybutyrate as the raw material, the carbapenem antibiotic drug intermediate 4-AA is prepared. Raw materials for the process are cheap and easily-available and can be purchased in quantity. The synthetic method has simple steps, yield of each step is high, and reactions are simple. By usinga chiral column as the split chiral center, use of a precious metals chiral reducing catalyst is avoided. the synthetic method of the invention has the following advantages: cost is low; yield is high; and reaction conditions are easily available.

The invention discloses a method for producing 2ZnO 3B2O3 3.5H2O (zinc borate), which is to make the 237 zinc borate react under a constant temperature in the water solution of boric acid for a certain period; then filter and wash directly upon the completion of the reaction, recover the washing liquid and the filtrate can be recovered for repetitive use; finally dry the filter cake to obtain the2ZnO 3B2O3 3.5H2O (zinc borate). The method of the invention has simple technique, the production process does not discharge wastewater and the production cost is low. The product can be used for flame-retardant material or daily chemical field, biological medicine field and so on.

The invention discloses a POSS-based adsorbent for heavy metal ions and a preparation method of the adsorbent, and belongs to the fields of environmental protection and material science. The adsorbenthas a structure represented by a formula (I) shown in the description. The preparation method comprises the following steps: performing a thiol-ene click chemistry reaction by using octavinyloctasilasesquioxane and mercaptothiadiazole as raw materials at room temperature to obtain the POSS-based adsorbent having the characteristics of the structure represented by the formula (I) for the heavy metal ions. The method provided by the invention is simple, high-efficiency, green and controllable, has mild reaction conditions, a simple treatment process, and discards a noble metal catalyst (such asa metal platinum catalyst) or complicated and harsh reaction conditions used in preparation of an adsorbent in the prior art; and the obtained adsorbent has the advantages of a fast adsorption speed,high saturated adsorption capacity and stable adsorption performance.

The invention relates to an extraction method for odourless DHA oil. The method comprises the steps of: (1) fermentation: fermenting DHA containing Schizochytrium limacinum to obtain a fermentation broth; (2) fermentation broth dehydration: subjecting the fermentation broth to natural sedimentation, removing part of water in the fermentation broth, and taking the sedimentated concentrated liquid; (3) washing: using a ceramic membrane to conduct recirculating filtration on the concentrated liquid and performing washing; (4) cell wall breaking by a high pressure homogenizer; (5) dehydration treatment on the cell wall broken concentrated liquid; and (6) dissolution of the dehydrated concentrated liquid in an n-hexane solvent or a 95% ethanol solvent to perform extraction and desolvation so as to obtain DHA oil. The method provided by the invention greatly improves the taste and odor of DHA oil, reduces the wall breaking time, also improves the extraction efficiency and productivity of the extraction section, and is basically free of emulsification phenomenon, greatly saves the production cost, and improves production efficiency.

The invention relates to the field of lithium battery electrolyte additives and in particular to an economic preparation method suitable for industrially producing lithium difluorophosphate. The method at least comprises the following steps: (1), enabling an oxidized boron compound to react with lithium hexafluorophosphate, to obtain a lithium difluorophosphate mixture; and (2), concentrating thelithium difluorophosphate mixture, adding a poor solvent, crystallizing, and separating to obtain the lithium difluorophosphate.

The invention provides a method for synthesizing (E)-2-hexenoic acid. The method comprises the following steps: using ethyl malonate as a raw material, and performing Knovenagel reaction, hydrolysis and decarboxylation on the ethyl malonate in a water phase to synthesize the (E)-2-hexenoic acid. Aiming at problems of strict reaction condition, serious side reaction, low yield and usage of a toxicreagent in the prior method for synthesizing the (E)-2-hexenoic acid, the method uses water as a reaction medium to realize clean and environment-friendly production without pollution, and has accessible raw materials with low cost, mild reaction condition, simple operation and easy industrialization. The synthesis method has few side reactions, and yield up to 75 to 85 percent.

The invention discloses a bismuth vanadate photoanode and its preparation method and application. The preparation method is as follows: sequentially preparing a bismuth vanadate layer and a carbon sphere layer on the surface of a transparent conductive substrate, and then repeatedly preparing a bismuth vanadate layer and a carbon sphere layer , so that an active layer is formed on the surface of the transparent conductive substrate, the active layer is formed by interlacing n-layer bismuth vanadate layers and n-1 layers of carbon sphere layers, the outermost layers on both sides of the active layer are bismuth vanadate layers, n is a natural number greater than 1; the bismuth vanadate precursor solution is spin-coated into a bismuth vanadate precursor film, then dried and calcined to form a bismuth vanadate layer; the bismuth vanadate precursor solution contains vanadium salt and bismuth salt; The carbon sphere dispersion liquid is spin-coated to form a carbon sphere film, and then dried to form a carbon sphere film. The bismuth vanadate photoanode provided by the present invention has higher electron-hole separation efficiency and fast water oxidation kinetics, so that it can achieve higher photocurrent density at lower bias voltage, showing higher Solar utilization.

The invention relates to a method for preparing ethyl 2-oxo-4-phenylbutyrate, which comprises the following steps: (1) reacting beta-halogeno ethylbenzene with magnesium in a first aprotic solvent to obtain a Grignard solution containing a Grignard reagent; (2) reacting ethyl oxalyl monochloride with one or more of CuX, Li2CuX4 and CuCN.LiX in a second aprotic solvent to obtain a solution containing a copper acyl chloride salt compound; and (3) dropwise adding the Grignard solution in the solution obtained in step (2), persevering the temperature at -20-160 DEG C, enabling the Grignard reagent to react with the cooper acyl chloride salt compound to obtain a product solution after the reaction is finished, carrying out acidic hydrolysis and alkali neutralisation on the product solution in sequence, washing, drying and removing the solvent, and obtaining the ethyl 2-oxo-4-phenylbutyrate with the purity no less than 97% after high vacuum rectification. The invention has the advantages of good reaction selectivity, high yield, easily obtained raw materials, mild reaction conditions, convenient operation and low cost.

The invention discloses a method for synthesizing biapenem medicine intermediates. The method has the advantages that the biapenem medicine intermediates 4-AA are prepared from (R)-3-polyhydroxybutyrate which is a raw material, and the raw material in the routes is inexpensive, is easily available and can be substantially purchased; the method includes simple steps, the various steps are high in yield, and reaction is simple; chiral reagents and chiral resolution are omitted, accordingly, the method is low in cost and high in yield, and reaction conditions are easily available.

The invention discloses a molybdenum-boron / sepiolite catalyst and its preparation method and application. The molybdenum-boron / sepiolite catalyst includes sepiolite as a carrier and the active component loaded on the sepiolite molybdenum and boron. The molybdenum-boron / sepiolite catalyst of the present invention has a wide range of sources of raw material sepiolite, low cost, environmental protection, can effectively reduce depolymerization costs, and is suitable for large-scale industrial applications, and the molybdenum-boron / sepiolite catalyst of the present invention Cooperating with the supercritical system, the conversion rate of depolymerized lignin is high, the selectivity of substituted phenols and carboxylic acid compounds is high, and the catalyst can be recycled more than 50 times.

The invention relates to a preparation method of 2-aryl-pentyne-4-olic acid ester compounds with a structure shown in a formula I, wherein R is described in the specification. The preparation method has the advantages of low cost and availability of raw materials, mild reaction conditions, simpleness in operation and suitability for industrial production.

The invention discloses a synthetic method of a carbapenem antibiotic drug intermediate. By using (R)-3-hydroxybutyrate as the raw material, the carbapenem antibiotic drug intermediate 4-AA is prepared. Raw materials for the process are cheap and easily-available and can be purchased in quantity. The synthetic method has simple steps, yield of each step is high, and reactions are simple. By usinga chiral column as the split chiral center, use of a precious metals chiral reducing catalyst is avoided. the synthetic method of the invention has the following advantages: cost is low; yield is high; and reaction conditions are easily available.

The invention discloses an adapter-modified magneto-optic dual-function contrast agent and a preparation method and application thereof. The contrast agent comprises silicon dioxide-coated trimanganese tetroxide nanoparticles, wherein the diameters of trimanganese tetroxide nanoparticles are 6-8 nanometers; the thickness of a silicon dioxide coating layer is 8-12 nanometers; the surface of the silicon dioxide coating layer is provided with an amino group and is coupled with a rhodamine isothiocyanate molecule and dicarboxyl polyethylene glycol through the amino group; and the dicarboxyl polyethylene glycol is connected with an adapter with an amino group. The contrast agent obtained in the invention has high monodispersity, high biocompatibility and targeting property, can be taken as a good T1 magnetic resonance imaging contrast agent, has high targeting property on tumor cells, and has wide application value in the fields of medicaments and biology; and the preparation method provided by the invention has the advantages of very low requirements on equipment, convenient operation process, low prices of need raw materials and nuisanceless byproducts.

The invention provides a preparation method of a beta-ketone substituted phosphate ester compound. The beta-ketone substituted phosphate ester compound is generated through a reaction of initial materials comprising alkenyl azide and phosphite ester in an organic solvent with manganese acetate as an oxidant. The preparation method has the advantages of reasonable design, easily available raw materials, mild reaction conditions, no high temperature reflow, high safety and convenience, and high yield, and allows the yield of most of products to be 70% or above. The preparation method is a method for constructing the beta-ketone substituted phosphate ester compound and having the advantages of simple operation, fastness, mildness and diversification; and the two initial raw materials are obtained through a one-step technology, so reaction raw materials are cheap and can be easily obtained. The general formula (I) of the beta-ketone substituted phosphate ester compound is shown in the description.