The invention relates to an economic and efficient method for asymmetric synthesis of R-configuration
aromatic alcohol through
copper salt
catalysis, and belongs to the technical field of preparing
optically active alcohol through
catalysis asymmetric hydrosilation. According to the method, Cu salt and chiral bisphosphine ligand form a clathrate with a certain
spatial configuration, and a substance with catalytic activity is formed by in-situ reaction under the action of stoichiometric hydrogenous
silane and is used for preparing the R-configuration
aromatic alcohol with asymmetric
catalysis hydrosilation reduction
aromatic ketone. According to the method, a non-
noble metal catalyst is adopted, raw materials are easy to get,
nitrogen protection is not needed, reaction condition is mild, operation is simple, use of hazardous articles, such as
hydrogen, can be avoided, the method is safe, reliable and environmental-friendly,
atom economy is good, substrate conversion rate is up to 99%, an
enantiomer excess value of the product of the R-configuration
aromatic alcohol is up to 93%, the simple, direct and efficient new method is provided for preparing chiral aromatic
alcohol, and the method has an important industrial application value.