Porous composite material long-term sugar control system and preparation method and application thereof

A technology of porous composite materials and porous materials, applied in the field of long-term sugar control system of porous composite materials, to achieve the effects of mild reaction conditions, convenient post-processing, and easy-to-obtain raw materials

Active Publication Date: 2020-01-03
ANHUI MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are relatively few reports on the construction and application of COFs porous materials in long-acting sugar control systems, especially the research on COFs porous materials as long-acting sugar control drug loading systems has not been reported. Sugar control research is a very challenging research direction

Method used

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  • Porous composite material long-term sugar control system and preparation method and application thereof
  • Porous composite material long-term sugar control system and preparation method and application thereof
  • Porous composite material long-term sugar control system and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The preparation method of the porous COFs composite system is as follows:

[0032] (1) Put the sugar-controlling drug insulin (Insulin or Ins for short) and the porous material in a mixed solvent of DMSO and PBS (volume ratio 1:1), and ultrasound to make the sugar-controlling drug fully penetrate into the porous material. In the pores of COF-1 and COF-5; among them, the synthesis of porous materials is a low-temperature (70~130℃) tube-sealing polymerization method, mainly by referring to the first article on COFs synthesis in 2005 (Cote, AP et al. Porous, crystalline, Covalent organicframeworks. Science 2005, 310, 1166-1170).

[0033] (2) Optimizing the product obtained in step (1), using a dialysis method to remove the unembedded sugar-controlling drugs, dialysis and freeze-drying to obtain a porous material loaded drug product;

[0034] (3) Combine the product obtained in step (2) with FITC-modified NH 2 -PEG-SH combined. Specific steps are as follows:

[0035] (a) The 4mg / ...

Embodiment 2

[0041] The preparation method of the porous COFs composite system is as follows:

[0042] (1) Put the sugar control drug insulin (Insulin or Ins for short) and the porous materials COF-1 and COF-5 in a mixed solvent of DMSO and PBS (volume ratio 1:1), and ultrasound to make the sugar control drug Fully penetrate into the pores of porous materials; among them, the synthesis of porous materials adopts low-temperature (70~130℃) sealed tube polymerization method, mainly referring to the first article on COFs synthesis in 2005 (Cote, AP et al. Porous, crystalline, Covalent organicframeworks. Science 2005, 310, 1166-1170).

[0043] (2) Optimize the product obtained in step 1), use a dialysis method to remove unembedded sugar control drugs, and freeze-dry to obtain a porous material loaded product;

[0044] (3) Combine the product obtained in step 2) with FITC-modified NH 2 -PEG-SH (FITC-PEG) combined. Specific steps are as follows:

[0045] (a) The 4mg / mL NH with a molecular weight of 200...

Embodiment 3

[0051] The preparation method of porous COFs composite material long-acting sugar control drug system is as follows:

[0052] (1) Take 2 mg of porous COFs (for example, COF-1, COF-5) materials, and compare them with 4 different 2 mg of glucose control drugs (insulin, biguanide drugs (metformin), sulfonylureas (glibenclamide, Gliclazide, glipizide, gliquidone, glimepiride, etc.), glinide drugs (repaglinide, nateglinide, etc.), alpha glucosidase inhibitors (aka Polose and voglibose, etc.), put them in a 1:1 mixed solvent of DMSO and PBS in a volume ratio of 1:1, and stir for a certain period of time, so that the drugs and COFs can fully permeate and combine with each other, and then shake well overnight. The drug enters the pores of COFs.

[0053] (2) After dialysis, the unbound drug is removed and then lyophilized to obtain a hydrophobic end product (the drug is embedded in a porous material).

[0054] (3) The product obtained in step (2) is combined with FITC modified NH 2 -PEG-SH ...

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Abstract

The invention discloses a porous composite material long-term sugar control system and a preparation method and application thereof. The porous composite material long-term sugar control system is formed by combining FITC modified NH2-PEG-SH and a porous material embedded with sugar control drugs, and then assembling; and a hydrophobic end and a hydrophilic end are contained, wherein the hydrophobic end is formed by embedding the sugar control drugs in the porous material, and the hydrophilic end is formed by chemical bond reaction of NH2-PEG-SH and FITC. The porous composite material long-term sugar control system has high loading capacity and excellent luminous characteristics, can be evenly and stably dispersed in an aqueous solution, and can long-term embed novel materials maintainingactivity of pancreas islet, and fast and stable blood glucose control is achieved.

Description

Technical field [0001] The invention relates to the field of medicine, in particular to a porous composite material long-acting sugar control system, its preparation method and application. Background technique [0002] Covalent Organic Frameworks (COFs) is a porous material composed entirely of organic structural units. It has the advantages of regular pore structure, large specific surface area, low density, high stability and easy-to-control functions. It has attracted widespread attention, and the American Chemical Society has rated it as one of the hot research directions in chemistry. COFs Since the Omar M. Yaghi group of the University of California, Berkeley reported the first COF-1 in 2005, the preparation and application of COFs materials have entered a period of rapid development. The Jiang Donglin research team of the Institute of Molecular Science of Japan introduced porphyrin, phthalocyanine, pyrene, perylene and other macrocyclic delocalized π-electron units into ...

Claims

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Application Information

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IPC IPC(8): A61K49/00A61K47/54A61K47/60A61K38/28A61P3/10
CPCA61K49/0021A61K47/547A61K47/60A61K38/28A61P3/10
Inventor 高杉张贵阳王小云宋梦梦
Owner ANHUI MEDICAL UNIV
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