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Nanometer ginkgo leaf extract external preparation and application thereof

An external preparation, the technology of ginkgo biloba, applied in the field of medicine, can solve problems such as potential safety hazards, achieve the effects of improving compliance, avoiding toxic and side effects, and improving bioavailability

Inactive Publication Date: 2012-05-02
张皓然
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Ginkgo biloba extract is currently clinically administered orally or intravenously, but the disadvantage is that oral administration has first-pass elimination effects and adverse reactions such as irritation to the gastrointestinal tract, such as dizziness, headache, fatigue, dry mouth, tongue, etc. Dryness, chest tightness, stomach discomfort, loss of appetite, abdominal distension, constipation, diarrhea, etc.
The complex components of Ginkgo biloba have huge safety risks when used as injections

Method used

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  • Nanometer ginkgo leaf extract external preparation and application thereof
  • Nanometer ginkgo leaf extract external preparation and application thereof
  • Nanometer ginkgo leaf extract external preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Ginkgo biloba extract raw materials are pulverized into an average particle size of 150nm by nanotechnology materials, and the ginkgo biloba extract cream is prepared according to the following prescription:

[0030]

[0031] Ginkgo biloba extract raw material is pulverized into an average particle size of 150nm by nanotechnology material, and is set aside. Put the prescribed amount of carbomer in 1 / 2 of the prescribed amount of purified water to swell for 24 hours and set aside. Dissolve anhydrous sodium sulfite, disodium edetate, and triethanolamine in the remaining prescription water and pour them into carbomer, stir evenly, heat to 75-80°C, and set aside. Heat stearic acid, glycerol monostearate, white petrolatum, pinpin, azone, and ethylparaben in the prescribed amount to 75-80°C until completely clarified, and keep warm for later use. Pour the water phase into the oil phase and stir evenly to obtain a blank cream. Throw the prescribed amount of nano-sized Egb...

Embodiment 2

[0033] Ginkgo biloba extract raw materials are pulverized into an average particle size of 600nm by nanotechnology materials, and the ginkgo biloba extract cream is prepared according to the following prescription:

[0034]

[0035] Ginkgo biloba extract raw material is pulverized into an average particle size of 600nm by nanotechnology material, and is set aside. Take stearic acid, stearyl alcohol, glyceryl monostearate, white petrolatum, liquid paraffin, and Span 60 and heat and melt to form an oil phase, and keep warm to 80-85°C. In addition, the water is heated to 80-85°C, and then the prescribed amount of Tween 80, methylparaben and EDTA are added to dissolve into the water phase. Pour the water phase into the oil phase, stir while adding, stop heating after 15-20 minutes, and continue stirring to room temperature. Add the main ingredient to the prescribed amount of glycerin, stir to disperse evenly, pour into the cream base, and stir evenly. The content is measured,...

Embodiment 3

[0037] Ginkgo biloba extract raw materials are pulverized into an average particle size of 150nm by nanotechnology materials, and the ginkgo biloba extract ointment is prepared according to the following prescription:

[0038]

[0039] Ginkgo biloba extract raw material is pulverized into an average particle size of 150nm by nanotechnology material, and is set aside. Take white vaseline and solid paraffin and heat to melt, and stir to room temperature. Add the main ingredient into the prescribed amount of liquid paraffin, stir to disperse evenly, pour into the ointment base, and stir evenly. The content is measured, filled and packaged to obtain ginkgo biloba extract ointment.

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Abstract

The invention provides a nanometer ginkgo leaf extract external preparation, which consists of a ginkgo leaf extract and a substrate, wherein the particle size of the ginkgo leaf extract is 10-1,000 nanometers. The invention further provides application of the nanometer ginkgo leaf extract external preparation to preparation of an anti-skin-aging and whitening medicament. Due to the adoption of the nanometer ginkgo leaf extract external preparation, the problem that the ginkgo leaf extract is difficult to absorb in the external preparation is solved, the skin permeation of the ginkgo leaf extract is enhanced, the skin absorption rate of the ginkgo leaf extract is increased, and the anti-skin-aging and whitening aims are fulfilled by locally applying externally. Skin tissues are taken as a permeation barrier, so that whole body absorption of the ginkgo leaf extract on a human body is limited, the toxic and side effects of the ginkgo leaf extract in the metabolic process of the human body are avoided, the anti-skin-aging and whitening effects are achieved, the bioavailability is enhanced, the adaptability of a patient is improved, and a novel administration measure is provided for the patient.

Description

technical field [0001] The invention relates to an external preparation of nanoscale ginkgo leaf extract and its application, belonging to the technical field of medicine. Background technique [0002] The compounds with medicinal components extracted from Ginkgo biloba are mainly total flavonoids and ginkgo lactones, etc., which are referred to as Ginkgo biloba extract (GBE) for short. Studies have shown that Ginkgo biloba extract is an antioxidant, which has a unique anti-free radical effect, inhibits the activity of platelet active factor PAF, can promote blood circulation in the skin, reduce the generation of free radicals, and prevent free radicals from damaging the skin. Prevent skin allergies, especially photosensitivity. Ginkgo biloba extract also has the effect of treating acne and whitening skin. Ginkgo biloba extracts have varying degrees of inhibitory effects on various types of bacteria. Ginkgolides are natural platelet activating factor receptor antagonists, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/16A61K9/14A61P17/00A61P17/18A61K127/00
Inventor 张皓然殷雨林陈红岩
Owner 张皓然
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