Unlock instant, AI-driven research and patent intelligence for your innovation.
Stable levocarnitine compound
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology of compounds and hydrates, applied in the field of stable levocarnitine compounds, which can solve problems such as affecting use and poor stability of levocarnitine
Active Publication Date: 2012-05-09
TIANJIN HANKANG PHARMA BIOTECH
View PDF4 Cites 1 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
[0010] The poor stability of levocarnitine, especially its strong hygroscopicity, affects its use, so it is made into pharmaceutically acceptable salts, such as sodium salt, hydrochloride, nitrate, tartrate, fumarate acid, mucate, etc., but there are still some defects
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0052]In a 2000ml reaction bottle equipped with stirring, thermometer and condenser, add 200g of levocarnitine and 1000ml of isopropanol-acetonitrile-water (5:3:2) mixture, start stirring, and heat up to 70°C -75°C, wait until it is completely dissolved, and filter while it is hot. The filtrate was naturally cooled to room temperature, and then kept warm for 8 hours to precipitate crystals, filtered, and dried indoors to obtain 181.6 grams of levocarnitine white crystals, with a melting point of 183.1°C-184.6°C, a content of 99.36%, and a specific rotation [a] 20 D is -31.1 (c=1,H 2 o). Determined by Karl Fischer method, it contains 14.30% (weight percent) of water.
[0053] The X-raydiffraction pattern of the crystal is shown in figure 1 . Instrument model and measurement conditions: Rigaku D / max 2500 diffractometer; CuKa 40Kv 100mA; 2θ scanning range: 0-50 ° .
[0054] Microparticles or microspheres are prepared by combining the compounds of the present invention wit...
[0057] Prescription: 100 grams of levocarnitine sesquihydrate, 650 grams of lactose, 80 grams of crospovidone, 50 grams of PEG-4000, 88 grams of hydroxypropyl methylcellulose, appropriate amount of distilled water, made into 1000 bags.
[0058] Process: PEG-4000 and levocarnitine sesquihydrate are crushed together, passed through an 80-mesh sieve, mixed with other materials, made into soft materials with distilled water, granulated, dried at low temperature, and then packed into granules.
[0061] Prescription: 50 grams of levocarnitine sesquihydrate, 5 ml of propylene glycol, 200 grams of starch, made into 1000 capsules.
[0062] Process: Moisten levocarnitine sesquihydrate and starch with 15% propylene glycolaqueous solution, mix well, sieve and granulate, dry at 60°C, granulate, and fill capsules.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to View More 
