Method for applying and preparing gamma-aminobutyric acid complex compound

A technology of aminobutyric acid and copper aminobutyrate is applied in the field of application and preparation of γ-aminobutyric acid complex, which can solve the problems of active destruction of nutrients, low biological potency, large gastrointestinal irritation, etc. Small stimulation, good heating uniformity, and responsive effects

Active Publication Date: 2012-07-11
XINGJIA BIO ENG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, inorganic metal salts are mostly used as animal feed additives. Animals must absorb and utilize the inorganic salts through various biological barriers to enter the body through free diffusion, etc., which greatly stimulates the stomach and intestines, and the absorption rate is low, and the amount added is large. The potency is low, and most of them will pollute the environment after excreted by feces, and have a destructive effect on the activity of other nutrients (such as vitamins, etc.) in the feed

Method used

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  • Method for applying and preparing gamma-aminobutyric acid complex compound
  • Method for applying and preparing gamma-aminobutyric acid complex compound
  • Method for applying and preparing gamma-aminobutyric acid complex compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Example 1: Preparation of copper γ-aminobutyric acid (the molar ratio of γ-aminobutyric acid to copper element is 1:1).

[0057] 3.4g cupric chloride dihydrate and 2.0g gamma-aminobutyric acid are added in the 50ml single-necked round bottom flask 4 of reaction device, add 20ml water as reaction bottom liquid, press figure 1 Connect the reaction device as shown (embodiments 2 to 14 are all prepared by this reaction device), and adjust the pH value of the reaction system to 4.5 with 1mol / L sodium hydroxide solution, and feed the condensate from the condensed water inlet 9 of the reaction device. water, then add the reaction bottom liquid from the upper port of the spherical reflux condenser 1 of the reaction device, until the liquid level of the reaction system reaches the glass water separator 2 (the glass water separator 2 of the reaction device passes through the adapter 8 and the ground glass After the trident tube 7 is connected to the branch pipe mouth of the singl...

Embodiment 2

[0058] Example 2: Preparation of copper gamma-aminobutyric acid (the molar ratio of gamma-aminobutyric acid to copper element is 2:1).

[0059] Add 2.5g of copper sulfate pentahydrate and 2.1g of γ-aminobutyric acid into the 25ml round bottom flask of the reaction device, add 10ml of ethanol-water solution system as the reaction bottom liquid, and adjust the pH of the reaction system with 0.5mol / L sodium carbonate solution value to 5.0, pour water into the water separator of the reaction device until the liquid level reaches the branch pipe mouth of the water separator, then turn on the stirrer for microwave heating and reflux reaction (microwave frequency is 2450MHz±50Hz, output power 80W), the whole process is controlled The pH value of the reaction system is about 5.0. When the microwave reaction is 8 minutes and 15 minutes, after taking samples in the water separator to measure the pH value, continue to add 0.5mol / L sodium carbonate solution to the nozzle of the reflux cond...

Embodiment 3

[0060] Example 3: Preparation of ferrous γ-aminobutyric acid (the molar ratio of γ-aminobutyric acid to iron element is 1:1).

[0061] Add 17.0g of ferrous sulfate monohydrate and 10.3g of gamma-aminobutyric acid into the 100ml round bottom flask of the reaction device, add 30ml of pure water as the reaction bottom liquid, and adjust the pH value of the reaction system with 1mol / L potassium hydroxide solution To 5.8, pour water into the water separator of the reaction device until the liquid level of the reaction system reaches the branch pipe mouth of the water separator, and then open the agitator to carry out microwave heating and reflux reaction (the frequency of microwave is 2450MHz±50Hz, output power 80W), The pH value of the reaction system is controlled at about 5.8 throughout the whole process. After the microwave reaction is performed every 15 minutes in the water separator to measure the pH value, continue to add 1 mol / L potassium hydroxide solution to the nozzle of ...

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Abstract

The invention discloses a method for applying and preparing a gamma-aminobutyric acid complex compound, namely the application of the gamma-aminobutyric acid complex compound served as animal feed additives. The preparation method for the gamma-aminobutyric acid complex compound served as the animal feed additives comprises the following steps of: adding an inorganic metal element compound served as a reaction raw material and gamma-aminobutyric acid into a reaction device according to a proportion, and simultaneously adding reaction base solution; regulating the pH value to be between 3 and 10; stirring and reacting, wherein the reaction time is between 5 minutes and 5 hours; controlling the pH valve of a reaction system to be between 3 and 10 in the whole process of the reaction, and keeping a backflow state; pouring a reaction product system into an organic solvent-water system for crystallizing after the reaction; and drying and granulating filtered crystal products, and thus obtaining products. The gamma-aminobutyric acid complex compound has the advantages of high biological value, low adding amount, obvious growth promoting effect, less side effects on animals, long-term use, safety, no drug resistance and the like.

Description

technical field [0001] The invention relates to the application and preparation of a feed additive, in particular to the application and preparation method of an amino acid complex as a feed additive. Background technique [0002] γ-Aminobutyric acid (GABA) is a strong neuroinhibitory amino acid. It is a naturally occurring non-protein amino acid. Physiological effects such as age. Aminobutyric acid acts on the GABA receptor in animal cells. The GABA receptor is a chloride ion channel. The inhibitory or excitatory properties of GABA depend on the concentration of chloride ions inside and outside the cell membrane. After the GABA receptor is activated, the chloride ion channel Opening can increase the permeability of the cell membrane to chloride ions, allowing chloride ions to flow into the nerve cells, causing hyperpolarization of the cell membrane, inhibiting the excitation of nerve cells, reducing the unconscious movement of animals, reducing energy consumption, so as to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23K1/16C07C229/76C07C227/18
Inventor 黄逸强
Owner XINGJIA BIO ENG CO LTD
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