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Medical bionic transparent film implanting material, and preparation method and application of material

A technology for implanting materials and transparent films, which is applied in the fields of biomaterials and biomedicine, can solve the problems of ignoring transparency or loading therapeutic substances, and achieve the effects of promoting cell adhesion and growth, reducing scars, and enhancing immunity

Inactive Publication Date: 2012-07-18
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, a lot of research has been done on nanofibrous film materials composited with collagen, chitosan, hyaluronic acid, etc. in skin injury repair, etc., but these studies often ignore the transparency of the material or the loading of therapeutic substances to enhance the treatment. Function

Method used

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  • Medical bionic transparent film implanting material, and preparation method and application of material
  • Medical bionic transparent film implanting material, and preparation method and application of material
  • Medical bionic transparent film implanting material, and preparation method and application of material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] 1) Dissolving type I collagen in an aqueous acetic acid solution with a mass concentration of 80% to prepare a type I collagen solution with a concentration of 85 mg / ml;

[0036] 2) Add chitosan substance at 4.0 mg / ml to the above-mentioned type I collagen solution, stir and dissolve, then add epidermal growth factor and stir to dissolve, the concentration of epidermal growth factor is 0.40 mg / ml;

[0037] 3) Put the uniformly stirred mixed solution in step 2) into the propulsion system liquid reservoir of the electrospinning device; use the conductor plate as the receiving carrier, adjust the distance between the hollow metal nozzle at the front end of the propulsion system and the receiving carrier to be 12 cm, and the carrier Ground the wire, connect the hollow metal nozzle to a DC voltage of 15 kV, and push out the mixed solution in the propulsion system at a speed of 0.3 ml / hour. After electrospinning for 6 hours, the nanofibers accumulate on the receiving carrier a...

Embodiment 2

[0041] 1) dissolving type II collagen in an aqueous acetic acid solution with a mass concentration of 65% to prepare a type II collagen solution with a concentration of 70 mg / ml;

[0042] 2) Add an equal amount of chitosan and hyaluronic acid to the above-mentioned type II collagen solution at a total concentration of 3.0 mg / ml, stir to dissolve, then add chondroitin sulfate and stir to dissolve, the concentration of chondroitin sulfate is 0.20 mg / ml ml;

[0043] 3) Put the uniformly mixed solution in step 2) into the propulsion system liquid reservoir of the electrospinning device; use the conductor plate as the receiving carrier, adjust the distance between the hollow metal nozzle at the front end of the propulsion system and the receiving carrier to be 10 cm, and the carrier Ground the wire, connect the hollow metal nozzle to a 10 kV DC voltage, and push out the mixed solution in the propulsion system at a speed of 0.2 ml / hour. After 8 hours of electrospinning, the nanofibe...

Embodiment 3

[0047] The preparation method is the same as in Example 1, the difference is that: change the 0.40 mg / ml epidermal growth factor into 0.10 mg / ml nano-silver particles, change the DC voltage applied by the metal needle to 8 kV, adjust the hollow metal nozzle at the front end of the propeller and The distance between the fiber receiving carriers was changed to 10 cm, the mixed solution in the propeller was pushed out at a speed of 0.25 ml / hour, and electrospinning was carried out for 7 hours, and the ultrafine fibers loaded with nano-silver particles accumulated autonomously on the receiving carrier to form a For a porous film with a certain porosity and thickness, the porous film is chemically cross-linked with 0.15% glutaraldehyde solution for 4 hours, then rinsed repeatedly with a phosphate buffer solution with a pH of 7.0, and then dried to obtain a transparent film containing nano-silver Material. The transparency of the film is 83.6%, the thickness is 680 microns, and the ...

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Abstract

The invention discloses a medical bionic transparent film implanting material which is a transparent porous material generated by electrostatic spinning and crosslinking. The thickness of the film ranges from 0.400 mu m to 800 mu m, the transparency of the film ranges from 75.0% to 99.9%, and the film comprises the following components in percentage by weight: 75.00%-95.00% of collagen, 1.50%-15.00% of polysaccharides, 0.01%-3.00% of therapeutic substances, and the balance being water. The film is prepared by an electrostatic spinning method. According to the invention, the technology is simple, the whole process is free of pollution, the transparency of the film is high, and the implanting material has a function of slow releasing on the loaded therapeutic substances, can remarkably improve a human tissue damage repair effect, and can be applied to ocular surface damage membrana tectoria, skin wound dressing, bone tooth defect regeneration guide films and other viscera repair separation films.

Description

technical field [0001] The invention relates to a medical bionic transparent film implant material and its preparation method and application, especially the preparation method and application of a collagen-based bionic transparent film material loaded with therapeutic substances in situ, belonging to the technical fields of biomedicine and biomaterials. Background technique [0002] Human ocular surface, skin and other tissues are prone to tissue damage due to bacterial infection, disease, corrosive substances or trauma. Covering exposed wounds with thin-film medical implant materials can reduce irritation or pain symptoms, reduce the possibility of infection, and promote tissue regeneration. purpose of repairing damage. Similarly, in bone defects such as skulls with severely damaged periosteum, filling particles, blocks or self-curing biomaterials and then covering with an artificial guide membrane with natural periosteum function can not only guide bone regeneration in...

Claims

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Application Information

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IPC IPC(8): A61L31/04A61L31/16A61L15/32A61L15/44D04H1/42D04H1/728
Inventor 叶娟苟中入石鑫
Owner ZHEJIANG UNIV
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