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Hydroxyapatite with flower-shaped level nanostructure and preparation method thereof

A hydroxyapatite and nanostructure technology, applied in nanotechnology, chemical instruments and methods, phosphorus compounds, etc., can solve the problem of small specific surface area of ​​hollow microspherical hydroxyapatite, low yield of hydroxyapatite, and complex process. and other problems, to achieve the effect of favorable industrialization promotion, good biocompatibility, and simple process

Inactive Publication Date: 2012-07-18
BEIJING FORESTRY UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method requires special template preparation and template removal, and the operation is relatively complicated (see J.K.Liu, Q.S.Wu, Y.P.Ding, Self-assembly and fluorescent modification of hydroxyapatite nanoribbon spherulites, Eur.J.Inorg.Chem.2005, 4145-4149)
[0010] The hydroxyapatite prepared in the above studies are all hollow microspheres. During the preparation process, the yield of hydroxyapatite in the hollow microspheres is low, the process is complicated, and the preparation process conditions are strict. The ratio of the prepared hollow microspherical hydroxyapatite is The surface area is small and the density is high, so the application in the fields of biology, medicine and bioengineering is limited

Method used

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  • Hydroxyapatite with flower-shaped level nanostructure and preparation method thereof
  • Hydroxyapatite with flower-shaped level nanostructure and preparation method thereof
  • Hydroxyapatite with flower-shaped level nanostructure and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0049] 1. At room temperature (25°C), add 0.110g CaCl 2 , 0.282g potassium sodium tartrate (C 4 h 4 o 6 KNa·4H 2 O) and 0.094g NaH 2 PO 4 2H 2 O was added to 15 mL of distilled water and stirred to obtain a uniformly dispersed suspension.

[0050] 2. Transfer all the suspension into a 20mL autoclave and seal it. Put the sealed autoclave into an oven, heat it to 300°C, and keep it warm at this temperature for 56 hours.

[0051] 3. After the autoclave was naturally cooled to room temperature (25°C), the product was taken out and centrifuged to separate the product. The obtained precipitate was washed twice with absolute ethanol and distilled water in turn, and then vacuum-dried at 60°C. The relative vacuum degree is -0.08MPa, and the hydroxyapatite with the flower-like secondary structure of the present invention is prepared.

[0052] figure 2 It is the X-ray diffraction spectrum of hydroxyapatite, and its X-ray diffraction spectrum is exactly the same as that of the ...

Embodiment 2

[0056] Except that the reactant is 0.176g C 4 h 6 o 4 Ca·H 2 O, 0.141g potassium sodium tartrate (C 4 h 4 o 6KNa·4H 2 O) and 0.054g KH 2 PO 4 15ml of distilled water was used for reaction; the reaction temperature was 250°C, and the reaction time was 52h, and the rest were the same as in Example 1.

[0057] The X-ray diffraction spectrum of the prepared hydroxyapatite is completely consistent with the standard JCPDS card (No.84-1998).

[0058] Scanning electron microscopy was used to detect the morphology of the prepared flower-like secondary structure of hydroxyapatite, and the detection results were as follows: Figure 5 as shown, Figure 5 b is a scanning electron micrograph of a single flower-like hydroxyapatite; Figure 5 c is a scanning electron micrograph of flower-like hydroxyapatite petals; Figure 5 d is a scanning electron micrograph of a single petal of flower-like hydroxyapatite.

Embodiment 3

[0060] Except that the reactant is 0.236g Ca(NO 3 ) 2 4H 2 O, 0.423g potassium sodium tartrate (C 4 h 4 o 6 KNa·4H 2 O) and 0.183g K 2 HPO 4 ·3H 2 O; 15ml of distilled water for reaction; the reaction temperature is 270° C., and the reaction time is 48h, and all the other are the same as in Example 1.

[0061] The X-ray diffraction spectrum of the prepared hydroxyapatite is completely consistent with the standard JCPDS card (No.84-1998).

[0062] Scanning electron microscopy was used to detect the morphology of the prepared flower-like hydroxyapatite, and the test results showed that the hydroxyapatite prepared in this example had a flower-like tertiary nanostructure, which was assembled from hydroxyapatite nanorods. Nanosheets, and then assembled into a flower-like structure by nanosheets. That is, the basic nanostructure unit of flower-like hydroxyapatite in this embodiment is hydroxyapatite nanorods (primary substructure), and hydroxyapatite nanorods are aggregate...

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Abstract

The invention provides hydroxyapatite with a flower-shaped level nanostructure and a preparation method thereof. The method comprises the following steps of: enabling water-soluble calcium salt, acid phosphate and potassium sodium tartrate to be subjected to hydrothermal reaction, and preparing the hydroxyapatite. The hydroxyapatite with the flower-shaped level nanostructure prepared by the method is characterized in that nanorods are assembled into nanosheets which are assembled into a flower-shaped nanostructure. The hydroxyapatite has the advantages of uniform particle size, single form, good dispersity, large specific surface area and wide application prospect in the biomedicine field and medicine releasing performance. The preparation method has the advantages of low price of materials, simple process, convenience in operation, easiness in control over process conditions, and reduction of cost; and meanwhile, the preparation method does not need complex and expensive equipment and is beneficial to industrialized popularization. The invention reports the hydroxyapatite with a flower-shaped tertiary-structured nanostructure and the preparation method thereof for the first time.

Description

technical field [0001] The invention relates to a phosphate and a preparation method thereof, in particular to a calcium phosphate and a preparation method thereof. Background technique [0002] Nanotechnology, information technology and biotechnology have become the three pillars of social development in the 21st century, and they are the strategic commanding heights that the world's major powers compete for. The combination of nanotechnology and biotechnology, especially with biomedical materials, gave birth to nano biomedical materials. Biomedical materials are materials used for medical purposes to diagnose, treat, repair or replace human tissues and organs or enhance their functions. Biomaterials are the basis for the study of artificial organs and medical devices, and have become an important branch of materials science. Especially with the rapid development and major breakthroughs of biotechnology, biomaterials have become a hot spot for research and development by s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32B82Y40/00
Inventor 马明国李书明付连花孙润仓许凤
Owner BEIJING FORESTRY UNIVERSITY
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