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Medicine composition for preventing or curing degenerative disease caused by oxidative stress

A technology for degenerative diseases and oxidative stress, applied in the direction of drug combination, active ingredients of fluorine compounds, active ingredients of iodine compounds, etc., can solve the problems of metabolism in vitro, easy disappearance of antioxidant activity, and inability to fully exert the effect of eliminating free radicals , to achieve the effect of high safety and few side effects

Inactive Publication Date: 2012-07-25
苏州本源生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0025] The main technical problem to be solved by the present invention is to provide a cell-optimized pharmaceutical composition for the prevention or treatment of degenerative diseases caused by oxidative stress, which can fill in the current treatment of middle-aged and elderly degenerative diseases a) carcinogenesis accompanied by hormone therapy or strong physiological side effects; b) Common antioxidants tend to lose their activity in vivo, and are easily metabolized out of the body quickly, and cannot fully exert the free radical elimination effect, etc.

Method used

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  • Medicine composition for preventing or curing degenerative disease caused by oxidative stress
  • Medicine composition for preventing or curing degenerative disease caused by oxidative stress
  • Medicine composition for preventing or curing degenerative disease caused by oxidative stress

Examples

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preparation example Construction

[0089] In the preparation of the pharmaceutical compositions, preparations and medicaments of the present invention, pharmaceutical adjuvants and / or carriers (excipients) may be used. For example, coloring agents, sweeteners, flavoring agents, binders, adsorbents, lubricants, disintegrants, softeners, suspending agents, emulsifiers, surfactants, stabilizers, pH regulators, dispersants, etc. can be used Osmotic agents, humectants, dissolving agents, solubilizers, and / or absorption enhancers are used as pharmaceutical adjuvants. These different forms can be prepared by conventional methods under sterile conditions.

[0090] In addition, in the administration form, according to the conditions of use, a functional coating such as an enteric coating may be further provided. In the case of administration in solid form, enteric coatings and shells can be used to complete the preparation. Additionally, such administration forms are capable of releasing the drug to certain parts of t...

Embodiment 1

[0125] Example 1: Injection solution

[0126] A mixture of hydroxylated antioxidant groups* with a hydroxylation rate of 86% (by mole conversion) and hydroxylated bioelement groups** with a hydroxylation rate of 87% (by mole conversion) at a weight ratio of 2:8. , after being completely dissolved in 1000cc of Ringer's solution for medicine at a concentration of 5 ppm, the sterile filter was used for the manufacture of injections to perform sterile filtration to prepare an injection solution as the cell optimizer for intravenous injection of the present invention.

[0127] * Hydroxylated Antioxidant Groups: Superoxide Dismutase (SOD), Catalase (CAT), Glutathione Peroxidase (GSH-Px), Glutathione, Melatonin, Fertility Trienols, Alpha Lipoic Acid

[0128] ** Hydroxylated bioelement groups: Bioelements (macro / trace elements)

Embodiment 2

[0129] Example 2: Powder for oral administration

[0130] A mixture of hydroxylated antioxidant groups* with a hydroxylation rate of 86% (mole conversion) and hydroxylated bioelement groups** with a hydroxylation rate of 87% (mole conversion) at a weight ratio of 2:8 , a cell-optimized complex formed by mixing 95% by weight and 5% by weight of dibenzofluoranthene (C20H10), diluted in mannitol at a concentration of 1% by weight, to prepare the following degenerative diseases Oral powder for prevention and treatment, including but not limited to myocardial infarction, ischemic heart disease, heart failure, angina pectoris, arrhythmia, arteriosclerosis, hepatic lipid metabolism disorder, hyperlipidemia, hypertension , arteriosclerosis, coronary arteriosclerosis, thrombosis, arteriosclerosis obliterans, vascular disease, peripheral vascular disease, cholestasis, hypercholesterolemia, limb injury, internal organ failure, acute and chronic hepatitis, stomach stains , duodenal ulce...

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Abstract

The invention discloses a cell optimizing medicine composition for preventing or curing a degenerative disease caused by oxidative stress, which comprises one or more types of proper quantities of effective bioelements, one or more types of antioxidant with effective dose, and one or more types of pharmaceutically acceptable carriers. The medicine composition not only contains effective antioxidant ingredients capable of clearing away radical and protecting DNA (deoxyribonucleic acid), protein and lipid against being injured, but also contains a trace element combination required for normal cell growth. The medicine composition has wide and excellent preventing and curing potency for the degenerative disease caused by oxidative stress, and has outstanding functions of high-efficient radical elimination activity and stability, few side effects in organisms, high safety and the like.

Description

[0001] technical field [0002] The present invention relates to the field of cell optimization, and more specifically, relates to a pharmaceutical composition for the prevention / treatment of degenerative diseases caused by oxidative stress. Background technique [0003] Body aging (also known as aging) is a comprehensive manifestation of functional decline and physiological disorders in the degenerative period of the human body. Physiological aging manifestations include increased body fat; decreased protein; decreased total body fluid volume; decreased liver function; and decreased function of the digestive system, respiratory system, cardiovascular system, urinary system, nervous system, and endocrine system. [0004] So far, more than 200 theories about aging have been proposed in the medical and biological circles, which can be summarized as explaining the mechanism of aging from the organ level and the cell level. [0005] I. Mechanism of organ aging [0006] Nervous...

Claims

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Application Information

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IPC IPC(8): A61K33/00A61K33/04A61K33/06A61K33/24A61K33/14A61K33/16A61K33/18A61K33/26A61K33/30A61K33/32A61K33/34A61K33/42A61K38/06A61K38/44A61P39/06A61K31/355A61K31/385A61K31/4045
Inventor 陈矶瑜
Owner 苏州本源生物技术有限公司
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