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Seabuckthorn flavone dispersible tablets

A technology of seabuckthorn flavonoids and dispersible tablets, which can be applied to medical preparations containing no active ingredients, medical preparations containing active ingredients, plant/algae/fungus/moss ingredients, etc. Problems such as medication problems in patients with swallowing difficulties, to achieve the effect of overcoming the problem of bitterness, rapid disintegration and dissolution, and improving compliance

Inactive Publication Date: 2012-11-14
石河子大学医学院第一附属医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0019] Chinese patent announcement number CN10537039A discloses a seabuckthorn flavonoid drop pill, but the drop pill formulation provided by this method does not solve the problem of bitter taste of seabuckthorn flavonoid
[0020] The Chinese patent notification number is CN101023969A, which makes seabuckthorn flavonoids into a soft capsule, but the soft capsule dosage form provided by this method cannot solve the medication problem of patients with swallowing difficulties
[0021] The Chinese patent notification number is CN1981789A, which makes seabuckthorn flavonoids into a kind of micropills, but the micropill dosage form provided by this method is a sustained-release dosage form, which cannot achieve the purpose of rapid onset by rapid drug release. Furthermore, Also did not solve the problem of bitter taste of seabuckthorn flavonoids

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Take an appropriate amount (about 6 grams) of seabuckthorn flavonoids, and the test shows that the active ingredient "flavones" is equivalent to 2478 mg of the total content of isorhamnetin, kaempferol, and quercetin. After grinding, pass through a 100-mesh sieve and set aside. Take 10 parts of seabuckthorn flavonoids, 9 parts of cross-linked polyvinylpyrrolidone, 38 parts of lactose, and 3 parts of sodium alginate, mix well, add 1 part of 65% ethanol for granulation, and make 0.9mm granules. After drying and sizing, 0.5 parts of magnesium stearate and 2.5 parts of aspartame are added, mixed evenly, and compressed into tablets to obtain the seabuckthorn flavonoid dispersible tablet of the present invention.

Embodiment 2

[0039] Example 2: Take an appropriate amount (about 5 grams) of seabuckthorn flavonoids, and the test shows that the active ingredient "flavones" is equivalent to 2065 mg of the total content of isorhamnetin, kaempferol, and quercetin. After grinding, pass through a 100-mesh sieve for future use . Take 15 parts of seabuckthorn flavonoids, 10 parts of sodium carboxymethyl starch, 30 parts of microcrystalline cellulose, 5 parts of pregelatinized starch, mix well, add 2 parts of 70% ethanol, and granulate to make 0.5mm granules. Dry and granulate under the condition of 50° C., add 0.8 parts of micropowder silica gel and 3 parts of aspartame, mix evenly, and press into tablets to obtain the seabuckthorn flavonoid dispersible tablet of the present invention.

Embodiment 3

[0040] Example 3: Take an appropriate amount (about 6 grams) of seabuckthorn flavonoids, and the test shows that the active ingredient "flavones" is equivalent to 2478 mg of the total content of isorhamnetin, kaempferol, and quercetin. After grinding, pass through a 100-mesh sieve and set aside . Take 20 parts of seabuckthorn flavonoids, 13 parts of cross-linked polyvinylpyrrolidone, 45 parts of mannitol, 6 parts of hydroxypropyl cellulose, mix well, add 2 parts of 70% ethanol, mix well, granulate, and make 0.8mm The granules are dried and sized at 55°C, and then 1 part of talcum powder and 1.6 parts of stevioside are added, mixed evenly and pressed into tablets to obtain the seabuckthorn flavonoid dispersible tablet of the present invention.

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PUM

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Abstract

The invention discloses seabuckthorn flavone dispersible tablets, which are prepared by mixing, pelletizing and tabletting 10-25 parts of seabuckthorn flavone, 8-16 parts of disintegrating agent, 30-60 parts of filling agent, 2-8 parts of swelling adjuvants, 1-5 parts of bonding agent, 0.5-1 parts of lubricating agent and 1-3 parts of flavoring agents. Compared with the prior art, the seabuckthorn flavone dispersible tablets provided by the invention are good in taste, short in disintegration time, and is capable of quickly disintegrating within 35-55 seconds, and medicines are dissolved out fast, thereby being capable of being sucked, swallowed, and taken after being added water to disperse. Therefore, the seabuckthorn flavone dispersible tablets are ideal medicinal preparation for preventing and treating cardiovascular and cerebrovascular diseases.

Description

technical field [0001] The invention relates to a seabuckthorn flavonoid dispersible tablet. Background technique [0002] Seabuckthorn is a traditional medicine of Mongolian and Tibetan medicine. It is warm in nature and sour in taste. It has the effects of nourishing yin and promoting body fluid, nourishing heart energy, nourishing and strengthening, and has a strong effect of promoting blood circulation and eliminating addiction. Modern pharmacology and clinical studies have confirmed that seabuckthorn flavonoids contained in seabuckthorn can increase myocardial blood flow, improve myocardial microcirculation, reduce myocardial oxygen consumption, resist arrhythmia, and expand blood vessels. Therefore, seabuckthorn flavonoids are used to treat angina pectoris, palpitation, palpitations, shortness of breath, chest tightness, and poor blood vessels. The general-purpose seabuckthorn flavonoids are alcohol extracts of seabuckthorn. Seabuckthorn flavonoids have a special stru...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K9/20A61K47/36A61K47/38A61P9/06A61P9/10
Inventor 王新春邢建国袁勇申雪丽韩博尹俊涛
Owner 石河子大学医学院第一附属医院
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